A5052867870- Metal complexes synthesis and properties
- Protein Interaction Studies and Fluorescence Analysis
- Ferrocene Chemistry and Applications
- DNA and Nucleic Acid Chemistry
- Lanthanide and Transition Metal Complexes
- Synthesis and Characterization of Heterocyclic Compounds
- Click Chemistry and Applications
- Organometallic Complex Synthesis and Catalysis
- Magnetism in coordination complexes
- X-ray Diffraction in Crystallography
- Quinazolinone synthesis and applications
- Synthesis and Reactivity of Heterocycles
- Synthesis and Biological Evaluation
- Drug Transport and Resistance Mechanisms
- Crystallization and Solubility Studies
- Synthesis of Tetrazole Derivatives
University of Kragujevac
2018-2025
This study investigates the synthesis, characterization, and cytotoxicity of dinuclear palladium(II) complexes with glycine (Pd1), alanine (Pd2), methionine (Pd3) as ligands. UV-Vis fluorescence spectroscopy were used to investigate complexes’ interactions calf thymus DNA (CT-DNA) bovine serum albumin. The obtained measurements demonstrate that Pd1 Pd2 have stronger binding affinities for CT-DNA compared Pd3, Pd3 exhibiting most significant against MDA-MB-231 cancer cell line. behavior was...
The synthesis, spectroscopic characterization, cytotoxic activity and DNA binding evaluation of seven new dinuclear platinum(ii) complexes Pt1-Pt7, with the general formula [{Pt(L)Cl}2(μ-1,5-nphe)](ClO4)2 (1,5-nphe is 1,5-naphthyridine; while L two ammines (Pt1) or one bidentate coordinated diamine: ethylenediamine (Pt2), (±)-1,2-propylenediamine (Pt3), trans-(±)-1,2-diaminocyclohexane (Pt4), 1,3-propylenediamine (Pt5), 2,2-dimethyl-1,3-propylenediamine (Pt6), 1,3-pentanediamine (Pt7)), were...
The dinuclear platinum(II) complexes, [{PtCl(NH 3 ) 2 } ( μ ‐1,6‐nphe)](ClO 4 Pt1 and [{Pt(en)Cl} Pt2 (en is a bidentate‐coordinated ethylenediamine 1,6‐nphe the bridging 1,6‐naphthyridine ligand) were synthesized characterized by different spectroscopic methods. DNA‐binding evaluation of complexes was done UV–Vis, fluorescence emission spectroscopy, their interaction with bovine serum albumin (BSA). cytotoxic activity these determined against mouse breast (4T1) colon (CT26) cancer cell...
Binuclear [{Pd (dien)} 2 ( μ ‐pz)](ClO 4 ) Pd1 and ‐pydz)](ClO Pd2 complexes, where pz is 1,4‐diazine pydz 1,2‐diazine bridging ligands dien (diethylenetriamine) a tridentately coordinated triamine ligand, were synthesized characterized using elemental analysis, NMR 1 H 13 C) spectroscopy, UV–Vis spectrophotometry. Electronic absorption spectrophotometry fluorescence spectroscopy used to study the interactions of prepared complexes with deoxyribonucleic acid (CT‐DNA) bovine serum albumin...
Abstract Five new dinuclear palladium(II) complexes with general formula, [{Pt(L)Cl} 2 ( μ ‐1,5‐nphe)](NO 3 ) (L is ethylenediamine (en), (±)‐1,2‐propylenediamine (1,2‐pn), trans ‐(±)‐1,2‐diaminocyclohexane (dach), 1,3‐propylenediamine (1,3‐pd), (±)‐1,3‐pentanediamine (1,3‐pnd) and 1,5‐nphe bridging 1,5‐naphthyridine ligand) were synthesised spectroscopically characterized. In vitro cytotoxic activity of these was evaluated against mouse mammary carcinoma (4T1), colon (CT26), lung cancer...
Dinuclear palladium(II) complexes, [{Pd(en)Cl}2(μ-L)](NO3)2 (L is bridging ligand pirazine (Pd1), pyrimidine (Pd2), pyridazine (Pd3), phenazine (Pd4) and en ethylenediamine), were synthesized characterized. The interactions of the complexes with biomolecules such as DNA BSA studied using UV–Vis spectroscopy fluorescence spectroscopy. Analysis tumoricidal activity investigated tested on several tumor cell lines human mouse origin, revealed that Pd1 Pd2 exhibited weak cytotoxic potential at...
Abstract The interactions of metal complexes with important biomolecules such as deoxyribonucleic acid (DNA) or bovine serum albumin (BSA) are responsible for their antitumor activity due to different modes interaction DNA and transport through the blood system cells tissues via albumin. Therefore, dinuclear palladium(II) complexes, [{Pd(en)Cl} 2 (μ-1,5-nphe)](NO 3 ) (Pd1) [{Pd(1,3-pd)Cl} (Pd2) (en is ethylenediamine, 1,3-pd 1,3-propylenediamine 1,5-nphe bridging 1,5-naphthyridine ligand)...
The series of nine dinuclear platinum(II) complexes, [{Pt(L)Cl}2(μ-X)]2+ (where L is two NH3 or bidentantly coordinated diamine ligand – ethylenediamine, en; (±)-1,2-propylenediamine, 1,2-pn; isobutylenediamine, ibn; trans-(±)-1,2-diaminocyclohexane, dach; 1,3-propylenediamine, 1,3-pd; 2,2- dimethyl-1,3-propylenediamine, 2,2-diMe-1,3-pd; (±)-1,3-pentanediamine,1,3-pnd, and X a bridging pyrazine (pz) pyridazine (pydz) ligand) have been synthesized characterized. antitumor potential these...