A5101397589- Cancer Genomics and Diagnostics
- Prostate Cancer Diagnosis and Treatment
- Urological Disorders and Treatments
- Sexual function and dysfunction studies
- Genetic factors in colorectal cancer
- Urinary Bladder and Prostate Research
- Renal and Vascular Pathologies
- Bacterial Identification and Susceptibility Testing
- Organ Donation and Transplantation
- Antimicrobial Resistance in Staphylococcus
- Prostate Cancer Treatment and Research
- Anesthesia and Sedative Agents
- MicroRNA in disease regulation
- Urologic and reproductive health conditions
- Extracellular vesicles in disease
- Pain Management and Opioid Use
- Orthopedic Surgery and Rehabilitation
- Anesthesia and Pain Management
- Lung Cancer Treatments and Mutations
- Airway Management and Intubation Techniques
- Bone fractures and treatments
- Infective Endocarditis Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Organ and Tissue Transplantation Research
- Foot and Ankle Surgery
Gujarat Cancer & Research Institute
2023-2024
King's College Hospital
2024
Saint Peter's University Hospital
2023
NIHR Surgical Reconstruction and Microbiology Research Centre
2023
Rutgers, The State University of New Jersey
2023
Florida College
2022
University of Florida
2022
Ahmedabad Civil Hospital
2022
Care Institute of Medical Sciences
2022
Cambridge University Hospitals NHS Foundation Trust
2015-2021
Selective sequencing or in silico analysis for differences DNA fragment size can improve the detection of circulating tumor DNA.
TP53 mutants (mutp53) are involved in the pathogenesis of most human cancers. Specific mutp53 proteins gain oncogenic functions (GOFs) distinct from tumor suppressor activity wild-type protein. Tumor-associated macrophages (TAMs), a hallmark solid tumors, typically correlated with poor prognosis. Here, we report non-cell-autonomous mechanism, whereby cancer cells reprogram to supportive and anti-inflammatory state. The colon harboring GOF selectively shed miR-1246-enriched exosomes. Uptake...
Abstract Tumour heterogeneity in primary prostate cancer is a well-established phenomenon. However, how the subclonal diversity of tumours changes during metastasis and progression to lethality poorly understood. Here we reveal precise direction metastatic spread across four lethal patients using whole-genome ultra-deep targeted sequencing longitudinally collected tumours. We find one case surgical bed causing local recurrence, another cross-metastatic site seeding combining with dynamic...
Infection control practices are not uniformly successful in limiting outbreaks of vancomycin-resistant enterococci (VRE). Despite the implementation barrier precautions for VRE-infected patients, nearly one-half inpatients at our center were found to have gastrointestinal colonization by VRE. In an attempt outbreak, we altered antibiotic formulary restricting use cefotaxime and vancomycin adding beta-lactamase inhibitors replace third-generation cephalosporins. The clindamycin was also...
Abstract Muscle Invasive Bladder Cancer (MIBC) has a poor prognosis. Whilst patients can achieve 6% improvement in overall survival with Neo-Adjuvant Chemotherapy (NAC), many do not respond. Body fluid mutant DNA (mutDNA) may allow non-invasive identification of treatment failure. We collected 248 liquid biopsy samples including plasma, cell pellet (UCP) and supernatant (USN) from spun urine, 17 undergoing NAC. assessed single nucleotide variants copy number alterations mutDNA using...
To evaluate the feasibility, safety, and outcome of laparoscopic kidney transplantation (LKT) after retroperitoneoscopic living-donor nephrectomy.Between February 2010 January 2012, a total 217 renal transplantations were performed from living donors by single surgical unit. All nephrectomies approach. Recipient surgery was either laparoscopically (n=72) or conventional open approach (n=145). In LKT group, 5 to 6 cm Pfannenstiel incision placed dropped into abdomen. Renal vessels anastomosed...
Laparoscopic donor nephrectomy has the advantages of less pain, early ambulation and shorter hospitalization compared to open nephrectomy. Kidney recipient surgery is, however, traditionally performed by surgery. Our aim was study feasibility safety laparoscopic kidney transplantation (LKT). After permission from Internal Review Board, LKT in four patients. All kidneys were procured deceased donors. Left used for transplanted left iliac fossa while right standard (OKT). procedures...
There is no uniformly accepted method for detecting colonization with vancomycin-resistant enterococci (VRE). The sensitivities of five culture methods were determined patients known to harbor VRE. Of 189 inpatients, 101 found VRE by at least one method. Three detected fewer than half the cultures. Campylobacter agar identified 70% patients. Enterococcosel broth (containing vancomycin and aztreonam) 88% may be preferred over other media routine surveillance.
Since Partin introduced the analysis of prostate-specific antigen, clinical T-stage and Gleason scores to estimate risk progression in men with localised prostate cancer, our understanding factors that modify this has changed drastically. There are now multiple stratification tools available, including look-up tables, stratification/classification analyses, regression-tree nomograms artificial neural networks. Concurrently, descriptions novel biopsy strategies, imaging modalities biomarkers...
Introduction: The aim of this study was to compare intraoperative and early post-operative outcomes between retzius-sparing robotic-assisted radical prostatectomy (RS-RARP) versus standard approach for RARP (S-RARP). Patients methods: All RARPs by a single surgeon were included divided into two groups: (1) including combined anterior–posterior (S-RARP); (2) posterior (RS-RARP). Allocation based on prostate size location index lesion MRI. Initial follow-up at 6 weeks. Results: Overall, 169...
To compare the efficacy and safety of oral transmucosal fentanyl citrate (OTFC) morphine in Indian patients with breakthrough episodes cancer pain.In this randomized, open label, active controlled, clinical study, total 186 who regularly experienced 1-4 pain (BTCP) daily, over persistent controlled by taking 60 mg/day or its equivalent were randomized to receive either OTFC 200 mcg 10 mg for treatment BTCP 3 days. Improvement as determined numerical rating scale (NRS) at 5, 15, 30, minutes...
Abstract To assess whether the timing of post-operative Phosphodiesterase Inhibitor (PDE5i) therapy after Robot-Assisted Radical Prostatectomy (RARP) is associated with a change in early erectile function (EF) outcomes, continence or safety outcomes. Data were prospectively collected from single surgeon one tertiary centre. 158 patients treated PDE5i post RARP over 2-year period. was started: immediately (day 1–2) post-op 29%, 3–14) 37% and late (after day 14) 34%. EPIC-26 EF scores pre-op...
Background: Post-operative pain relief after lumbar laminectomy and stabilization surgery is related to soft tissue muscle dissection, manipulation removal at the operating site. Aims & Objectives: The present study designed evaluate pre-emptive effect of 0.5% Ropivacaine infiltration in patients undergoing laminectomy. Materials Methods: In this prospective, randomized study, seventy five belonging ASA I II were randomly allocated three groups as group A, B C. After conventional general...
Introduction: Laryngoscopy and intubation as well application of skull pin in neurosurgical procedure is a highly noxious stimulus which causes hemodynamic changes can be detrimental patients with raised intracranial pressure. We studied the effect addition intravenous labetalol fentanyl to attenuate pressure response insertion neurosurgery. Materials Methods: Fifty undergoing elective were randomised into two groups group LF F. Patients received Labetalol 0.25mg/kg 5 minutes prior 2µg/kg 3...
Context: Key to successful awake direct laryngoscopy is establishing reliable local anesthesia. Lidocaine spray was reported be effective in laryngoscopic procedure with less hemodynamic and cardiovascular disturbances. Novel formulation of lidocaine as lozenges developed avoid problems throat irritation bitter taste associated spray. Aims: The aim the following study compare efficacy safety versus patients undergoing diagnostic laryngoscopy. Design: A prospective, randomized, open label,...
Introduction Hindfoot intramedullary nail fixation (HFN) or fibula pro-tibial screw (PTS) are surgical options for ankle fractures in patients with multiple co-morbidities; we compared their outcomes. Methods A retrospective review of 135 who underwent HFN (87 patients) PTS (48 (AO/OTA A/B/C) from 5 major trauma centres. Patient demographic data, co-morbidities, Charlson Co-morbidity Index Score (CCIS), weight-bearing, and post-operative complications were recorded. Radiographs assessed...
Urachal tumors are rare and comprise of both benign malignant neoplasms. Epithelial origin more common than mesenchymal tumors. We report a case inflammatory myofibroblastic tumor (IMFT) in 12 year old boy who presented with symptoms lower abdominal pain burning micturition. Upon evaluation was found to have soft tissue mass anterior urinary bladder wall. A laparoscopic excision done. Histopathological immunohistochemical examination confirmed the diagnosis IMFT. Next generation sequencing...
Abstract Objectives To assess whether the timing of post-operative Phosphodiesterase Inhibitor (PDE5i) therapy after Robot Assisted Radical Prostatectomy (RARP) is associated with a change in early erectile function outcomes. Additionally, to determine there are differences continence or safety Subjects/patients and methods Data was prospectively collected from single surgeon one tertiary centre retrospectively evaluated. 158 patients were treated PDE5i post RARP over two-year period....
Background: Previous abdominal surgery and its related adhesions are usually a relative contraindication for laparoscopic or reason conversion. Objectives: This study aim to identify patients with previous compare the clinical outcomes in without surgery. Patients Methods: Data was collected prospectively from September 2006 Dec 2010 of all colorectal resections done both benign malignant diseases. Results: Out 718 476 had no (Group A), whilst 190 not involving colonic B), 52 bowel C). The...