A5024068362- Alzheimer's disease research and treatments
- Neurobiology and Insect Physiology Research
- Robotic Locomotion and Control
- Neuroinflammation and Neurodegeneration Mechanisms
- Insect and Arachnid Ecology and Behavior
- Neuroscience and Neuropharmacology Research
- Computational Drug Discovery Methods
- Cholinesterase and Neurodegenerative Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Biomimetic flight and propulsion mechanisms
Cyprus Institute of Neurology and Genetics
2022-2023
University of Cologne
2022
Alzheimer's disease (AD) is a progressive neurodegenerative and the most common type of dementia. Although considerably large amount money has been invested in drug development for AD, no modifying treatment detected so far. In our previous work, we developed computational method to highlight stage-specific candidate repurposed drugs against AD. this study, tested effect top 13 that proposed work severity manner using an vitro BACE1 assay top-ranked from list tetrabenazine (TBZ), 5XFAD as AD...
Alzheimer's disease (AD) is a progressive neurodegenerative of the brain causing either familial or sporadic dementia. We have previously administered modified C5a receptor agonist (EP67) for short period to transgenic mouse model AD (5XFAD) and observed not only reduction in β-amyloid deposition gliosis but also improvement cognitive impairment. Inquiring, however, on effects EP67 an already heavily burdened animal, thus representing more realistic scenario, we treated 6-month-old 5XFAD...
Alzheimer's disease (AD) is an irreversible neurodegenerative disorder characterized by amyloid plaques, neurofibrillary tangles, and cerebral angiopathy (CAA). CAA a condition manifesting as deposits in the vasculature, eventually leading to microhemorrhage. Here, we have treated CRND8 mouse model with C5a agonist (EP67) order observe effects on amyloidosis, CAA, hyperphosphorylated tau. EP67 attaches receptor phagocytes stimulates engulfment digestion of fibrillar prefibrillar while...
Abstract The walking system of the stick insect is one most thoroughly described invertebrate systems. We know a lot about role sensory input in control stepping single leg. However, neuronal organization and connectivity central neural networks underlying rhythmic activation coordination leg muscles still remain elusive. It assumed that these can couple absence phasic due to observation spontaneous recurrent patterns (SRPs) coordinated motor activity equivalent fictive stepping-phase...
The walking system of the stick insect is one most thoroughly described invertebrate systems. We know a lot about role sensory input in control stepping single leg. However, neuronal organization and connectivity central neural networks underlying rhythmic activation coordination leg muscles still remain elusive. It assumed that these can couple absence phasic due to observation spontaneous recurrent patterns (SRPs) coordinated motor activity equivalent fictive stepping-phase transitions....