A5063933209- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Computational Drug Discovery Methods
- Bioinformatics and Genomic Networks
- Pharmacological Receptor Mechanisms and Effects
- Receptor Mechanisms and Signaling
- Veterinary Pharmacology and Anesthesia
- Stress Responses and Cortisol
- Nanoparticle-Based Drug Delivery
- Pain Management and Opioid Use
- Neuroendocrine regulation and behavior
- COVID-19 and Mental Health
- Misinformation and Its Impacts
- Protein Degradation and Inhibitors
- Vaccine Coverage and Hesitancy
- Pharmacogenetics and Drug Metabolism
- Cholinesterase and Neurodegenerative Diseases
- Pain Management and Placebo Effect
- Neuroethics, Human Enhancement, Biomedical Innovations
- Sirtuins and Resveratrol in Medicine
- Eicosanoids and Hypertension Pharmacology
- Photodynamic Therapy Research Studies
- vaccines and immunoinformatics approaches
- Connective tissue disorders research
- Quinazolinone synthesis and applications
University of Cyprus
2016-2025
University of Leicester
2009-2018
University of Tasmania
2014-2018
Leicester Royal Infirmary
2009-2018
Treatment of breast cancer underwent extensive progress in recent years with molecularly targeted therapies.However, non-specific pharmaceutical approaches (chemotherapy) persist, inducing severe side-effects.Phytochemicals provide a promising alternative for prevention and treatment.Specifically, resveratrol (res) is plant-derived polyphenolic phytoalexin potent biological activity but displays poor water solubility, limiting its clinical use.Here we have developed strategy delivering res...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is undeniably the most global health emergency since 1918 Influenza outbreak. Depending on its evolutionary trajectory, virus expected to establish itself as an endemic infectious disease exhibiting seasonal flare-ups. Therefore, despite unprecedented rally reach a vaccine that can offer widespread immunization, it equally important effective prevention and treatment regimens for 2019 (COVID-19). Contributing this...
Alzheimer's disease (AD) is a progressive neurodegenerative and the most common type of dementia. With no disease-curing drugs available an ever-growing AD-related healthcare burden, novel approaches for identifying therapies are needed. In this work, we propose stage-specific candidate repurposed against AD by using network-based method drug repurposing different stages severity. For each stage, approach a) ranks based on score emerging from weighted sum connections in network resembling...
Coumarin-6 is used as a model hydrophobic drug to investigate delivery tumors via polymeric micelles. Photophysical characterization, well in vitro and vivo experiments showcase this platform for cancer diagnosis imaging.
Efficient repetitive clinical use of morphine is limited by its numerous side effects, whereas analgesic tolerance necessitates subsequent increases in dose to achieve adequate levels analgesia. While many studies focused on tolerance, the effect dosing non-analgesic effects has been overlooked. This study aimed characterize morphine-induced behavior and development progression behavioral tolerance. Adult male Sprague–Dawley rats were repetitively treated with subcutaneous for 14 days two...
The epidermal growth factor receptor (EGFR) is a key target in anticancer research, whose aberrant function malignancies has been linked to severe irregularities critical cellular processes, including cell cycle progression, proliferation, differentiation, and survival. EGFR mutant variants, either transmembrane or translocated the mitochondria and/or nucleus, often exhibit resistance inhibitors. ability noninvasively image quantify provides novel approaches detection, monitoring, treatment...
Targeting more than one opioid receptor type simultaneously may have analgesic advantages in reducing side-effects. We evaluated the mixed μ agonist/ δ antagonist UFP-505 vitro and vivo.
In the area of drug research, several computational repurposing studies have highlighted candidate repurposed drugs, as well clinical trial that tested/are testing drugs in different phases. To best our knowledge, aggregation proposed lists by previous has not been extensively exploited towards generating a dynamic reference matrix with enhanced resolution. fill this knowledge gap, we performed weight-modulated majority voting modes action, initial indications and targeted pathways...
In this study we aimed to look at the effects of opioid-receptor selective agonists and antagonists on insulin secretion in pancreatic β-cell line RIN-5F. Cells were treated for 24 hours with 1μM (DAMGO MOP, DPDPE DOP, U50488 KOP) presence or absence 10μM (CTOP naltrindole norBNI KOP). An enzyme-based immunoassay was used detect amount supernatant, using a standard curve generated from known concentrations rat insulin. A trypan blue viability assay performed assess toxicity each treatment...
Alzheimer's disease (AD) is a progressive neurodegenerative and the most common type of dementia. Although considerably large amount money has been invested in drug development for AD, no modifying treatment detected so far. In our previous work, we developed computational method to highlight stage-specific candidate repurposed drugs against AD. this study, tested effect top 13 that proposed work severity manner using an vitro BACE1 assay top-ranked from list tetrabenazine (TBZ), 5XFAD as AD...
This article contains supportive data related to a research entitled "Age-dependent antinociception and behavioral inhibition by morphine" (Paul et al., 2018) [1]. Antinociceptive latencies of 8 24-week old rats were obtained from tail-flick hot plate assays after morphine treatment. Motor effects measured at different time-points using automated infrared tracking in an open-field arena. Residual content post-mortem tissues 240 min post-treatment. Concurrent measurements antinociception,...
University students represent a highly active group in terms of their social activity the community and propagation information on media. We aimed to map knowledge, attitudes, perceptions Cyprus about severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Coronavirus disease 2019 (COVID-19) guide targeted future measures campaigns. used cross-sectional online survey targeting all conventional, not distance-learning, programs five major universities Republic Cyprus. Students were...