A5025440739- Earthquake Detection and Analysis
- earthquake and tectonic studies
- Bioinformatics and Genomic Networks
- Seismology and Earthquake Studies
- Computational Drug Discovery Methods
- Complex Systems and Time Series Analysis
- Statistical Mechanics and Entropy
- High-pressure geophysics and materials
- Genetic Neurodegenerative Diseases
- Bartonella species infections research
- Vector-borne infectious diseases
- Protein Degradation and Inhibitors
- Gene Regulatory Network Analysis
- Rabies epidemiology and control
- Geochemistry and Geologic Mapping
- Microbial Metabolic Engineering and Bioproduction
- Viral Infections and Vectors
- Seismic Imaging and Inversion Techniques
- Geological and Geochemical Analysis
- Helicobacter pylori-related gastroenterology studies
- Neurological disorders and treatments
- RNA and protein synthesis mechanisms
- Mitochondrial Function and Pathology
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
Cyprus Institute of Neurology and Genetics
2017-2024
Interbalkan Medical Center
2020
National Observatory of Athens
2010-2018
University Hospital of Heraklion
2002-2017
Brunel University of London
2011-2014
National Observatory
2014
University of Crete
2003-2012
Technological Educational Institute of Athens
2002-2010
Abstract. We used the earthquake catalogue of INGV extending from 1 January 2006 to 30 June 2009 detect significant changes before and after 6 April L'Aquila mainshock (Mw=6.3) in seismicity rate, r (events/day), b-value. The statistical z-test Utsu-test were applied identify changes. From beginning up end October 2008 activity was relatively stable remained state background (r=1.14, b=1.09). 28 26 March 2009, increased significantly 2.52 indicating weak foreshock sequence; b-value did not...
This study aims to highlight SARS-COV-2 mutations which are associated with increased or decreased viral virulence. We utilize genetic data from all strains available GISAID and countries’ regional information, such as deaths cases per million, well COVID-19-related public health austerity measure response times. Initial indications of selective advantage specific can be obtained calculating their frequencies across strains. By applying modelling approaches, we provide additional information...
Abstract Heterogeneity in the severity of Parkinson’s disease (PD) inhibits effective interpretation clinical trial outcomes. Multi-omics analysis may help explain pathological mechanisms underlying progression and reveal biomarkers severity. We performed Multi-Omics Factor Analysis (MOFA) on whole blood RNA, miRNA Cerebrospinal fluid (CSF) plasma proteomics from Progression Marker Initiative (PPMI), to identify molecular factors correlated with motor (MDS-UPDRS3) cognitive (Semantic Fluency...
The abundance of available information for each disease from multiple sources (e.g. as genetic, regulatory, metabolic, and protein-protein interaction) constitutes both an advantage a challenge in identifying disease-specific underlying mechanisms. Integration multi-source data is rising topic great precision medicine crucial enhancing understanding, meaningful clusters molecular mechanisms increasing personalisation towards the goal Predictive, Preventive Personalised Medicine (PPPM)....
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is undeniably the most global health emergency since 1918 Influenza outbreak. Depending on its evolutionary trajectory, virus expected to establish itself as an endemic infectious disease exhibiting seasonal flare-ups. Therefore, despite unprecedented rally reach a vaccine that can offer widespread immunization, it equally important effective prevention and treatment regimens for 2019 (COVID-19). Contributing this...
On 26.1.2014 and 3.2.2014 two strong earthquakes of M<sub>w</sub>6.0 M<sub>w</sub>5.9 ruptured the western Cephalonia Isl., Ionian Sea (Greece), at SSW-wards continuation Lefkada segment Transform Fault Zone (CTFZ), causing considerable damage a variety ground failures. High-precision relocation aftershocks implies that seismogenic layer was 35 km in length (L) striking NNE-SSW, 10 maximum width 15 thickness. Two aftershock spatial clusters were revealed north...
PathwayConnector is a web-tool that facilitates the construction of complementary pathway-to-pathway networks and subnetworks them, based on reference pathway network derived from rich information available either in KEGG or Reactome database for mapping. Specifically, given set pathways, (i) finds all direct connections between (ii) adds minimum pathways required to achieve connectivity leading informative fully connected provides series clustering methods further grouping sub-clusters. The...
The present study aimed at identifying the acoustic pattern of vocalizations, produced by 7- to 11-month-old infants, that were interpreted their mothers as expressing emotions or communicative functions. Participants 6 healthy, first-born English 3 boys and girls, mothers. analysis vocalizations was performed using a recognition (PR) software system. A PR system not only calculates signal features, it also automatically detects patterns in arrangement such features. following results...
Extracellular matrix (ECM)-related adhesion proteins are important in metastasis. Ras suppressor-1 (RSU-1), a suppressor of Ras-transformation, is localized to cell–ECM adhesions where it interacts with the Particularly Interesting New Cysteine-Histidine rich protein (PINCH-1), being connected Integrin Linked Kinase (ILK) and alpha-parvin (PARVA), direct actin-binding protein. RSU-1 was also found upregulated metastatic breast cancer (BC) samples recently demonstrated have...
In this paper we show, in terms of Fisher information and approximate entropy, that the two strong impulsive kHz electromagnetic (EM) bursts recorder prior to Athens EQ (7 September 1999, magnitude 5.9) present compatibility radar interferometry data seismic analysis, which indicate fault segments were activated during EQ. The calculated entropy content ratios closely follow result main segment was responsible for 80% total energy released, while secondary remaining 20%. This experimental...
Abstract Variants of unknown/uncertain significance (VUS) pose a huge dilemma in current genetic variation screening methods and counselling. Driven by next generation sequencing (NGS) such as whole exome (WES), plethora VUS are being detected research laboratories well the health sector. Motivated this overabundance VUS, we propose novel computational methodology, termed VariantClassifier (VarClass), which utilizes gene-association networks polygenic risk prediction models to shed light...
Abstract. Many questions about earthquake (EQ) generation remain standing. Fracture induced electromagnetic (EM) fields allow real-time monitoring of damage evolution in materials during mechanical loading. An improved understanding the EM precursors has direct implications for study EQ processes. important challenge this direction is to identify an observed anomaly a recorded time series as pre-seismic one and correspond distinct stage generation. In previous papers (Kapiris et al., 2004;...
The advancement of scientific and medical research over the past years has generated a wealth experimental data from multiple technologies, including genomics, transcriptomics, proteomics, other forms -omics data, which are available for number diseases. integration such multisource is key component toward success precision medicine. In this paper, we investigating method developed by our group, regarding its ability to drive clusters connected pathways under two different approaches: first,...
Abstract. The monitoring of statistical network properties could be useful for the short-term hazard assessment occurrence mainshocks in presence foreshocks. Using successive connections between events acquired from earthquake catalog Istituto Nazionale di Geofisica e Vulcanologia (INGV) case L'Aquila (Italy) mainshock (Mw = 6.3) 6 April 2009, we provide evidence that measures, both global (average clustering coefficient, small-world index) and local (betweenness centrality) ones,...
Drug repurposing techniques allow existing drugs to be tested against diseases outside their initial spectrum, resulting in reduced cost and eliminating the long time-frames of new drug development. In silico further speeds up process either by proposing suitable invert transcriptomic profile a disease or indicating based on common targets structural similarity with other similar mode action. Such methods usually return number potential repurposed that need vitro, pre-clinical clinical...