A5048068750- Blood disorders and treatments
- Acute Myeloid Leukemia Research
- Mesenchymal stem cell research
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Neutropenia and Cancer Infections
- Hematopoietic Stem Cell Transplantation
- Hematological disorders and diagnostics
- Immune cells in cancer
- Blood groups and transfusion
- Lymphoma Diagnosis and Treatment
- Platelet Disorders and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Bone Tissue Engineering Materials
- Bone and Joint Diseases
- MicroRNA in disease regulation
- Hemoglobinopathies and Related Disorders
- 3D Printing in Biomedical Research
- Cancer Cells and Metastasis
- Electrospun Nanofibers in Biomedical Applications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Fungal Infections and Studies
- Lymphatic System and Diseases
- Angiogenesis and VEGF in Cancer
- Inflammation biomarkers and pathways
University of Crete
2016-2025
University Hospital of Heraklion
2016-2025
Zero to Three
2020
Centre for Research and Technology Hellas
2019
Foundation for Research and Technology Hellas
2018
Université de Tours
2008-2016
National and Kapodistrian University of Athens
2015
John Wiley & Sons (United States)
2014
Établissement Français du Sang
2009
Inserm
2008-2009
Mucormycosis is a life-threatening respiratory fungal infection predominantly caused by Rhizopus species. has incompletely understood pathogenesis, particularly how abnormalities in iron metabolism compromise immune responses. Here we show how, as opposed to other filamentous fungi, spp. establish intracellular persistence inside alveolar macrophages (AMs). Mechanistically, lack of swelling conidia results surface retention melanin, which induces phagosome maturation arrest through...
Abstract Lineage-priming is a molecular model of stem cell (SC) differentiation in which proliferating SCs express subset genes associated to the pathways they can commit. This concept has been developed for hematopoietic SCs, but poorly studied other SC populations. Because potential human bone marrow mesenchymal cells (BM MSCs) remains controversial, we have explored theory lineage-priming applied these cells. We show that primary layers and clones BM MSCs precise priming osteoblastic (O),...
In view of the current interest in exploring clinical use mesenchymal stem cells (MSCs) from different sources, we performed a side-by-side comparison biological properties MSCs isolated Wharton's jelly (WJ), most abundant MSC source umbilical cord, with bone marrow (BM)-MSCs, extensively studied population.MSCs were and expanded BM aspirates hematologically healthy donors (n = 18) WJ full-term neonates 18). We evaluated, parallel experiments, immunophenotypic, survival senescence...
Defective hematopoiesis supporting capacity of bone marrow (BM) stroma has been implicated in the pathophysiology myelodysplastic syndromes (MDS). The aim this study is to explore whether BM progenitors, namely mesenchymal stem cells (MSCs), are primarily affected MDS by evaluating reserves, functional properties, as well cytogenetic characteristics, comparison hematopoietic cells, patients with de novo (n = 13). number, differentiation potential toward adipocytes/chondrocytes/osteoblasts...
It has been shown that bone marrow mesenchymal stromal cells (MSCs) from patients with myelodysplastic syndromes (MDSs) display defective proliferative potential. We have probed the impaired replicative capacity of culture-expanded MSCs in MDS (n=30) compared healthy subjects (n=32) by studying senescence characteristics and gene expression associated WNT/transforming growth factor-β1 (TGFB1) signaling pathways. also explored consequences patient MSC potential investigating their...
In addressing the critical role of emotional context in patient–clinician conversations, this study conducted a comprehensive sentiment analysis using BERT, RoBERTa, GPT-2, and XLNet. Our dataset includes 185 h Greek conversations focused on hematologic malignancies. The methodology involved data collection, annotation, model training, performance evaluation metrics such as accuracy, precision, recall, F1-score, specificity. BERT outperformed other methods across all categories,...
Background: Cardiac amyloidosis (CA) is a progressive disorder characterized by amyloid fibril deposition in the heart, leading to heart failure and arrhythmias. Arterial stiffness, assessed pulse wave velocity (PWV), recognized as an adverse consequence of amyloidosis, yet its progression relationship with myocardial dysfunction remain inadequately explored. This study examines PWV potential association deterioration global longitudinal strain (GLS) CA patients over 6-month follow-up...
Abstract Similar to other adult tissue stem/progenitor cells, bone marrow mesenchymal stem/stromal cells ( BM MSC s) exhibit heterogeneity at the phenotypic level and in terms of proliferation differentiation potential. In this study such a was reflected by CD 200 protein. We thus characterized pos sorted from whole cultures we investigated molecular mechanisms regulating expression. After sorting, measurement lineage markers showed that osteoblastic genes RUNX 2 DLX 5 were up‐regulated...
Background Lenalidomide improves erythropoiesis in patients with low/intermediate-1 risk myelodysplastic syndrome and interstitial deletion of the long arm chromosome 5 [del(5q)]. The aim this study was to explore effect lenalidomide treatment on reserves functional characteristics bone marrow hematopoietic progenitor/precursor cells, stromal cells peripheral blood lymphocytes del(5q).Design Methods We evaluated number clonogenic potential erythroid/myeloid/megakaryocytic progenitor using...
Bone homeostasis is maintained by the balance between bone-forming osteoblasts and bone-degrading osteoclasts. Osteoblasts have a mesenchymal origin whereas osteoclasts belong to myeloid lineage. Osteoclast osteoblast communication occurs through soluble factors secretion, cell-bone interaction cell–cell contact, which modulate their activities. CD200 an immunoglobulin superfamilly member expressed on various types of cells including stem (MSCs). receptor (CD200R) such as...