A5069996839- Muscle Physiology and Disorders
- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Metal complexes synthesis and properties
- Regulation of Appetite and Obesity
- Trace Elements in Health
- Drug Transport and Resistance Mechanisms
- Neuropeptides and Animal Physiology
- Genomics, phytochemicals, and oxidative stress
- Pharmacological Receptor Mechanisms and Effects
- Biochemical Analysis and Sensing Techniques
- Adipokines, Inflammation, and Metabolic Diseases
- Coenzyme Q10 studies and effects
- Exercise and Physiological Responses
- Colorectal Cancer Treatments and Studies
- Echinoderm biology and ecology
- bioluminescence and chemiluminescence research
- Protein Degradation and Inhibitors
- Phytochemistry and Bioactive Compounds
- Diet, Metabolism, and Disease
- Immunotoxicology and immune responses
- Seaweed-derived Bioactive Compounds
- Digestive system and related health
- ATP Synthase and ATPases Research
- Ion Transport and Channel Regulation
University of Tasmania
2014-2025
Ingham Institute
2016
Western Sydney University
2016
UNSW Sydney
2016
Launceston General Hospital
2016
Santhera Pharmaceuticals (Switzerland)
2009-2011
Fucoidans are sulfated, complex, fucose-rich polymers found in brown seaweeds. have been shown to multiple bioactivities, including anti-inflammatory effects, and known inhibit inflammatory processes via a number of pathways such as selectin blockade enzyme inhibition, demonstrated inhibition pathologies vivo. In this current investigation, fucoidan extracts from Undaria pinnatifida, Fucus vesiculosus, Macrocystis pyrifera, Ascophyllum nodosum, Laminaria japonica were assessed for modulation...
Background: Medulloblastoma (MB) is the most aggressive paediatric brain cancer, highlighting urgent need for new diagnostic and prognostic biomarkers improved treatments to enhance patient outcomes. Our previous study identified LIN28B, an RNA-binding protein, as a potential marker MB pharmacological target inhibit cell proliferation stemness. However, specific role of LIN28B its mechanism action in had not been studied. Methods: This assessed LIN28B's Daoy cells using siRNA-mediated...
New medicines are urgently required to treat the fatal neuromuscular disease Duchenne muscular dystrophy (DMD). Dimethyl fumarate (DMF) is a potent immunomodulatory small molecule nuclear erythroid 2-related factor 2 activator with current clinical utility in treatment of multiple sclerosis and psoriasis that could be effective for DMD rapidly translatable. Here, we tested weeks daily 100 mg/kg DMF versus 5 standard-care prednisone (PRED) juvenile mdx mice early symptomatic DMD. Both drugs...
Asperuloside is an iridoid glycoside found in many medicinal plants that has produced promising anti-obesity results animal models. In previous studies, three months of asperuloside administration reduced food intake, body weight, and adipose masses rats consuming a high fat diet (HFD). However, the mechanisms by which exerts its properties were not clarified. Here, we investigated homeostatic nutrient-sensing regulating intake mice HFD. We confirmed and, importantly, identified some could...
Bitter Melon (BM) has been used as a functional food in traditional Chinese and Indian medicine for many generations gained great deal of attention due to its apparent benefits moderating some the pathogenic processes variety inflammatory conditions. BM extract (BME) shown possess strong anti-oxidant properties. In addition, it can ameliorate oxidative stress potentially ER stress. There is increasing evidence that are major contributors intestinal secretory cell dysfunction which leads...
To determine if exacerbation of pre-existing chronic colitis in Winnie (Muc2 mutant) mice induces colonic dysplasia.Winnie and C57BL6 as a genotype control, were administered 1% w/v dextran sulphate sodium (DSS) orally, followed by drinking water alone week-long cycles for total three cycles. After the third cycle, killed tissue collected histological immunohistochemical evaluation. Inflammation severity dysplasia mucosa assessed H&E sections colon. Epithelial cell proliferation was using...
Endoplasmic reticulum (ER) stress and oxidative have recently been linked to the pathogenesis of inflammatory bowel diseases. Under physiological conditions, intestinal epithelial cells are exposed ER affecting cellular ionic homeostasis. However, these altered ion flux 'signatures' during conditions poorly characterized. We investigated kinetics K(+) , Ca(2+) H(+) fluxes in a colonic cell line LS174T using non-invasive microelectrode estimation technique. were induced by exposure...
In this study we aimed to look at the effects of opioid-receptor selective agonists and antagonists on insulin secretion in pancreatic β-cell line RIN-5F. Cells were treated for 24 hours with 1μM (DAMGO MOP, DPDPE DOP, U50488 KOP) presence or absence 10μM (CTOP naltrindole norBNI KOP). An enzyme-based immunoassay was used detect amount supernatant, using a standard curve generated from known concentrations rat insulin. A trypan blue viability assay performed assess toxicity each treatment...
Obesity produces a systemic low-grade inflammation associated with many adverse health conditions and, as we recently learned, complications of COVID-19. Functional studies in animal models have demonstrated that asperuloside, an iridoid glycoside found medicinal plants, has produced promising anti-obesity results. However, the safety profile and anti-inflammatory properties asperuloside remain unknown. Here, confirmed previously reported importantly, performed toxicity assessing cell...
Depression is a common mental disorder that affects people of all ages across the world. All current pharmacological interventions are based on monoamine theory depression and aim to increase concentrations monoamines in brain. However, since many patients show no response or do not tolerate conventional therapies, there an urgent need identify new therapeutic targets, explore molecular pathways develop novel drugs against depression. Opioids, class compounds used chronic pain, have major...
Abstract New medicines are urgently required to treat the fatal neuromuscular disease, Duchenne muscular dystrophy (DMD). DMD involves progressive muscle damage and weakness, which preceded by oxidative stress, inflammation, mitochondrial dysfunction. Dimethyl fumarate (DMF) is a potent small molecule nuclear erythroid 2-related factor 2 (Nrf2) activator with current clinical utility in treatment of multiple sclerosis psoriasis. Pharmaceutical targeting Nrf2 DMF has strong translational...
Controlling the urge to eat requires adequate integration of hypothalamic neuropeptides regulating energy balance processes with dopaminergic circuits in mesolimbic pathway. Disruption this signalling alters hedonic control reward‐driven food intake contributing obesity. Our study aimed understand mechanism action novel anti‐obesity compound, asperuloside (ASP), and whether ASP treatment could be used as safe weight loss treatment. Mice were fed a 45% high fat diet (HFD) concurrently treated...