A5012060954- Muscle Physiology and Disorders
- Exercise and Physiological Responses
- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Cancer Treatment and Pharmacology
- Nutrition and Health in Aging
- Mitochondrial Function and Pathology
- Vitamin D Research Studies
- Biochemical and Molecular Research
- Cardiomyopathy and Myosin Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Neurogenetic and Muscular Disorders Research
- Genomics, phytochemicals, and oxidative stress
- Cancer-related cognitive impairment studies
- Diet and metabolism studies
- Eating Disorders and Behaviors
- Genetic Neurodegenerative Diseases
- Coenzyme Q10 studies and effects
- Histone Deacetylase Inhibitors Research
- Colorectal Cancer Treatments and Studies
- Tissue Engineering and Regenerative Medicine
- Psoriasis: Treatment and Pathogenesis
- Folate and B Vitamins Research
- Nitric Oxide and Endothelin Effects
- Inflammatory Myopathies and Dermatomyositis
Australian Institute for Musculoskeletal Science
2014-2024
University Children’s Hospital Basel
2022-2024
Western Health
2014-2024
The University of Melbourne
2021-2024
Victoria University
2015-2024
Sunshine Hospital
2020-2024
Victoria School of Management
2016
Duchenne Muscular Dystrophy (DMD) is a fatal neuromuscular disease that characterised by dystrophin-deficiency and chronic Ca2+-induced skeletal muscle wasting, which currently has no cure. DMD was once considered predominantly as metabolic due to the myriad of insufficiencies evident in musculature, however this aspect been extensively ignored since discovery dystrophin. The collective historical contemporary literature documenting these nuances culminated series studies importantly...
Duchenne Muscular Dystrophy is a chronic, progressive and ultimately fatal skeletal muscle wasting disease characterised by sarcolemmal fragility intracellular Ca2+ dysregulation secondary to the absence of dystrophin. Mounting literature also suggests that dysfunction key energy systems within may contribute pathological reducing ATP availability regulation fibre regeneration. No study date has biochemically quantified contrasted mitochondrial production capacity dystrophic mitochondria...
Eccentric exercise-induced damage leads to reductions in muscle force, increased soreness, and impaired function. Creatine monohydrate's (Cr) ergogenic potential is well established; however few studies have directly examined the effects of Cr supplementation on recovery after damage. We proteins force eccentrically-induced healthy individuals.Fourteen untrained male participants (22.1 +/- 2.3 yrs, 173 7.7 cm, 76.2 9.3 kg) were randomly separated into 2 supplement groups: i) carbohydrate...
We examined the effects of short-term consumption whey protein isolate on muscle proteins and force recovery after eccentrically-induced damage in healthy individuals.Seventeen untrained male participants (23 ± 5 yr, 180 6 cm, 80 11 kg) were randomly separated into two supplement groups: i) (WPH; n = 9); or ii) carbohydrate (CHO; 8). Participants consumed 1.5 g/kg.bw/day (~30 g immediately, then once with breakfast, lunch, afternoon evening meal) for a period 14 days following unilateral...
Myostatin inhibition therapy has held much promise for the treatment of muscle wasting disorders. This is particularly true fatal myopathy, Duchenne Muscular Dystrophy (DMD). Following on from promising pre-clinical data in dystrophin-deficient mice and dogs, several clinical trials were initiated DMD patients using different modality myostatin therapies. All failed to show modification disease course as dictated by primary secondary outcome measures selected: story, thus far, a story. These...
Abstract Arising from the ablation of cytoskeletal protein dystrophin, Duchenne Muscular Dystrophy (DMD) is a debilitating and fatal skeletal muscle wasting disease underpinned by metabolic insufficiency. The inability to facilitate adequate energy production may impede calcium (Ca 2+ ) buffering within, regenerative capacity of, dystrophic muscle. Therefore, increasing metabogenic potential could represent an effective treatment avenue. aim our study was determine efficacy adenylosuccinic...
COVID-19 has rapidly spread worldwide and incidences of hospitalisation from respiratory distress are significant. While a vaccine is in the pipeline, there urgency for therapeutic options to address immune dysregulation, hyperinflammation oxidative stress that can lead death. Given shared pathogenesis severe cases with aspects multiple sclerosis psoriasis, we propose dimethyl fumarate as viable treatment option. Currently approved an immunomodulatory, anti-inflammatory anti-oxidative drug...
Chemotherapy is a leading intervention against cancer. Albeit highly effective, chemotherapy has multitude of deleterious side-effects including skeletal muscle wasting and fatigue, which considerably reduces patient quality life survivability. As such, defence chemotherapy-induced dysfunction required. Here we investigate the effects oxaliplatin (OXA) treatment in mice on mitochondria, capacity for Poly ADP-ribose polymerase (PARP) inhibitor, BGP-15, to ameliorate any pathological induced...
Gastrointestinal side effects of chemotherapy are an under-recognized clinical problem, leading to dose reduction, delays and cessation treatment, presenting a constant challenge for efficient tolerated anti-cancer treatment. We have found that oxaliplatin treatment results in intestinal dysfunction, oxidative stress loss enteric neurons. BGP-15 is novel cytoprotective compound with potential HSP72 co-inducing PARP inhibiting properties. In this study, we investigated the alleviate...
Duchenne muscular dystrophy arises from the loss of dystrophin and is characterized by calcium dysregulation, atrophy, metabolic dysfunction. The secondary reduction neuronal nitric oxide synthase (nNOS) sarcolemma reduces NO production bioavailability. As modulates glucose uptake, metabolism, mitochondrial bioenergetics, we investigated whether an 8-week nitrate supplementation regimen could overcome dysfunction in mdx mouse. Dystrophin-positive control (C57BL/10) dystrophin-deficient mice...
New medicines are urgently required to treat the fatal neuromuscular disease Duchenne muscular dystrophy (DMD). Dimethyl fumarate (DMF) is a potent immunomodulatory small molecule nuclear erythroid 2-related factor 2 activator with current clinical utility in treatment of multiple sclerosis and psoriasis that could be effective for DMD rapidly translatable. Here, we tested weeks daily 100 mg/kg DMF versus 5 standard-care prednisone (PRED) juvenile mdx mice early symptomatic DMD. Both drugs...
Abstract Female carriers of a Duchenne muscular dystrophy ( DMD ) gene mutation manifest exercise intolerance and metabolic anomalies that may be exacerbated following menopause due to the loss estrogen, known regulator skeletal muscle function metabolism. Here, we studied impact estrogen depletion (via ovariectomy) on tolerance mitochondrial metabolism in female mdx mice potential replacement therapy (using estradiol) protect against functional perturbations. We also investigated effect...
Hyperhomocysteinemia (HHcy) impairs nitric oxide endothelium-dependent vasodilation, consequently leading to atherosclerosis, a risk factor for cardiovascular disease. Novel treatments HHcy are necessary.We tested the hypothesis that alamandine, vasoactive peptide of renin-angiotensin system (RAS), could reverse HHcy-induced vascular dysfunction through MrgD receptor and this is mediated by protein kinase A (PKA) pathway. Furthermore, we sought determine putative binding model alamandine...
Gastrointestinal dysfunction is a common side-effect of chemotherapy leading to dose reductions and treatment delays. These side-effects may persist up 10 years post-treatment. A topoisomerase I inhibitor, irinotecan (IRI), commonly used for the colorectal cancer, associated with severe acute delayed-onset diarrhoea. The long-term effects IRI be due damage enteric neurons innervating gastrointestinal tract controlling its functions. Balb/c mice received intraperitoneal injections (30...
Fumaric acid esters (FAEs) are small molecules with anti-oxidative, anti-inflammatory and immune-modulating effects. Dimethyl fumarate (DMF) is the best characterised FAE approved registered for treatment of psoriasis Relapsing-Remitting Multiple Sclerosis (RRMS). Psoriasis RRMS share an immune-mediated aetiology, driven by severe inflammation oxidative stress. DMF, as well monomethyl diroximel fumarate, commonly prescribed first-line agents favourable safety efficacy profiles. The potential...