A5101786235- Hip disorders and treatments
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Shoulder Injury and Treatment
- Receptor Mechanisms and Signaling
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neuropeptides and Animal Physiology
- Protein Kinase Regulation and GTPase Signaling
- Hormonal Regulation and Hypertension
- Coronary Interventions and Diagnostics
- Peripheral Artery Disease Management
- Diabetes Management and Education
- Primary Care and Health Outcomes
- Retinal Diseases and Treatments
- Knee injuries and reconstruction techniques
- Apelin-related biomedical research
- Monoclonal and Polyclonal Antibodies Research
- Acute Myocardial Infarction Research
- Pain Mechanisms and Treatments
- Health Policy Implementation Science
- Lower Extremity Biomechanics and Pathologies
- Cardiac, Anesthesia and Surgical Outcomes
- Healthcare cost, quality, practices
- Vitamin K Research Studies
- Neonatal and Maternal Infections
The University of Texas Southwestern Medical Center
2008-2020
Southwestern Medical Center
2020
Columbia University
2018-2019
Bidwell Memorial Presbyterian Church
2019
Leicester Royal Infirmary
2006-2018
University of Leicester
2000-2018
East Lancashire Hospitals NHS Trust
2012-2015
Texas Orthopedic Hospital
2013
HealthPartners
2000-2006
Victoria Heart Institute Foundation
2006
We investigated the role played by agonist-mediated phosphorylation of Gq/11-coupled M3-muscarinic receptor in mechanism activation mitogen-activated protein kinase pathway, ERK-1/2, transfected Chinese hamster ovary cells. A mutant receptor, where residues Lys370–Ser425 third intracellular loop had been deleted, showed a reduced ability to activate ERK-1/2 pathway. This reduction was evident despite fact that able couple efficiently phospholipase C second messenger Importantly, responses...
Agonist-mediated receptor phosphorylation by one or more of the members G-protein kinase (GRK) family is an established model for G-protein-coupled (GPCR) resulting in desensitization. Our recent studies have, however, suggested that alternative route to GPCR may be operation involving casein 1alpha (CK1alpha). In current study we investigate involvement CK1alpha human m3-muscarinic intact cells. We show expression a catalytically inactive mutant CK1alpha, designed act dominant negative...
Properdin is a normal serum protein which increases the production of complement activation products by binding to C3b integral convertase complexes and amplifying their activity at site activation. Thereby, it can aid in resolution infection but also contribute tissue damage. In human sepsis, circulating C3 concentrations are decreased, though described as positive acute phase reactant. However, properdin levels sepsis have not been reported. this study, from 81 critically ill patients...
1University of Texas Southwestern Medical Center, 1801 Inwood Road, Dallas, TX 75390. E-mail address: [email protected] 2Orthopedics Administration E2300, Children’s Center 1935 District Drive, 75235.
Purpose of review: Total hip replacement is one the safest and most clinically efficacious operations in orthopedic surgery. It has been extended to more patient populations over past four decades. The purpose this review present contemporary data total two unique populations: obese patients geriatric older than 75 years age. Recent findings: There are clinical challenges these patients. In addition, outcome complications different from routine populations. Summary: recent research shown...
Background: East Lancashire Hospitals NHS Trust reorganized its services in October 2007 with acute admissions sent to one site which allowed the development of a 24/7 Consultant delivered cardiology service.Methods: A retrospective analysis all patients admitted an coronary syndrome between two periods: Group 1: 2006 September and 2: 2008. We looked at following end points—length stay, in-hospital 30 day cause mortality.Results: 633 group 1 748 2. There was significant reduction length stay...
Background: Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant vascular dysplasia characterized by spontaneous, recurrent epistaxis. Epistaxis ranges from sporadic, low volume bleeds to frequent hemorrhages causing anemia. In moderate-severe cases, KTP laser photocoagulation and/or electrocautery are commonly utilized control Objective: This observational cohort study aims evaluate the efficacy of therapy combined with cautery as treatment for epistaxis in HHT. Methods:...
Purpose of review Total hip replacement is one the safest and most clinically efficacious operations in orthopedic surgery. It has been extended to more patient populations over past four decades. The purpose this present contemporary data total two unique populations: obese patients geriatric older than 75 years age. Recent findings There are clinical challenges these patients. In addition, outcome complications different from routine populations. Summary recent research shown that elderly...