A5011178337- Acute Myeloid Leukemia Research
- Respiratory viral infections research
- Diabetes Management and Research
- Viral Infections and Vectors
- Blood groups and transfusion
- Lymphoma Diagnosis and Treatment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Antimicrobial Resistance in Staphylococcus
- Erythrocyte Function and Pathophysiology
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Sarcoma Diagnosis and Treatment
- Virology and Viral Diseases
- Nutrition, Health and Food Behavior
- Bacterial Identification and Susceptibility Testing
- Streptococcal Infections and Treatments
- Glycosylation and Glycoproteins Research
- Chronic Lymphocytic Leukemia Research
- Neonatal Health and Biochemistry
- Pancreatic function and diabetes
- Eating Disorders and Behaviors
- Advanced Biosensing Techniques and Applications
- Cardiac electrophysiology and arrhythmias
- Autoimmune and Inflammatory Disorders Research
Korea University
2011-2024
Korea University Medical Center
2016-2023
Hanyang University
2018
Hanyang University Medical Center
2018
Kangwon National University
2017
Asan Medical Center
2015
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections and hospitalization in infants young children. Here, we analyzed genetic diversity RSV using partial G gene sequences 84 RSV-A 78 RSV- B positive samples collected Seoul, South Korea, for 10 consecutive years, from 2010 to 2019. Our phylogenetic analysis revealed that strains were classified into either ON1 (80.9%) or NA1 (19.0%) genotypes. On other hand, RSV-B demonstrated diversified clusters...
Abstract Background Currently, SARS‐CoV‐2 RNA detection using real‐time reverse‐transcription PCR (rRT‐PCR) is the standard diagnostic test for COVID‐19 infection. Various rRT‐PCR assays are currently used worldwide, targeting different genes of SARS‐CoV‐2. Here, we compared analytical sensitivity and clinical performance (sensitivity specificity) Allplex SARS‐CoV‐2/FluA/FluB/RSV assay (Seegene), Standard M nCoV kit (SD Biosensor), U‐TOP (Seasun Biomaterials) detection. Methods Two hundred...
The fifth edition of the WHO classification (2022 WHO) and International Consensus Classification ICC) myeloid neoplasms have been recently published. We reviewed changes in diagnosis distribution patients with MDS excess blasts (MDS-EB) or AML using both classifications. Forty-seven previously diagnosed as having MDS-EB available mutation analysis data, including targeted next-generation RNA-sequencing were included. reclassified 15 (31.9%) 27 (57.4%) based on 2022 ICC, respectively. One...
There are growing concerns regarding the spread of carbapenemase-producing organisms (CPOs) among patients in long-term care facilities (LTCFs) and hospitals South Korea. We have established a screening protocol for detection CPOs high-risk upon admission to intensive units (ICUs). The diagnostic performance Xpert Carba-R assay was compared that rectal culture CPO ICU admission. A total 408 consecutive swabs were obtained from December 2016 2017. performed using (Cepheid, Sunnyvale, CA,...
This study aimed to investigate the relationship between marital status and incidence of metabolic syndrome in Korean middle-aged women.Based on data from sixth Korea National Health Nutrition Examination Survey (2013-2014), 3,225 women aged 40-69 years were subjected analysis. Marital was categorized as married, unmarried, separated, widowed, or divorced. The odds ratios (ORs) for calculated based status. After adjustment age, income level, education alcohol intake, smoking status, leisure...
eISSN 2093-6338 와 거핵구 생착을 지연시킬 수 있다[1]. 따라서 ABO 혈액형의 동종응집소 역가는 부적합 골수이 식 또는 장기 이식에서의 경과 관찰 및 예후 평가, 아형에 대한 검사, 혈액형 수혈 시 반응에 등에 도움을 줄 있다[2-5]. 특히 이식 후 거부반응의 예측에 중 요한 정보를 제공하여 혈장 교환술, 비장절제, 항-CD20 단클론성 항체, 면역글로불린 정주요법 등과 같은 치료방법의 선택에 도움 을 있는데[6], 인종이나 연령간 유의한 차이를 보일 있을 뿐 아니라, 검사법에 많은 영향을 받을 있다. 동종응집소는 측정방법에 따라 시험관법, 미세원주응집 법, 효소면역법, 유세포분석법 등 다양하게 측정될 있으며 이
Tuberculosis (TB) is one of the leading causes infectious mortality from a single agent, Mycobacterium tuberculosis (MTB). This study evaluated performance newly developed BZ TB/NTM NALF assay, which integrated loop-mediated isothermal amplification and lateral flow immunochromatographic assay technologies, for detection MTB. A total 80 MTB-positive samples 115 MTB-negative were collected, all confirmed by TB real-time PCR (RT-PCR) using either AdvanSureTM RT-PCR Kit or Xpert® MTB/RIF Assay....
It is well known that breastfeeding has a significant impact on the health of mothers and children. With growing importance breastfeeding, present study aimed to investigate relationship between prevalence diabetes in Korean parous women.The data 5,448 premenopausal women aged 20-49 years who agreed participate 5th- 6th Korea National Health Nutrition Examination Survey were analyzed this study. Control group included had not breastfed. The subjects breastfed classified into three groups...
The Rh blood group D antigen is the most immunogenic of all antigens, next to ABO antigens. Anti-D immunization clinically important since it may cause clinical problems, such as severe hemolytic transfusion reactions and disease newborn. DEL an extremely weak variant that cannot be detected by basic serologic typing typed D-negative without absorption-elution techniques RHD genotyping. Of phenotype, (c.1227G>A) allelic common in Korea. phenotype has been considered carry only a few antigens...
Complex karyotype (CK) is associated with a poor prognosis in both acute myeloid leukemia (AML) and myelodysplastic syndrome excess blasts (MDS-EB). Transcriptomic analyses have improved our understanding of the disease risk stratification neoplasms; however, CK-specific gene expression signatures been rarely investigated. In this study, we developed validated signature. Differential analysis between CK non-CK groups using data from 348 patients AML MDS-EB four cohorts revealed enrichment...
Point-of-care (POC) testing provides quick results and includes tests for blood glucose lipid profiles. We evaluated the newly developed POC device, GCare Lipid Analyzer, which is used to measure glucose, total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C) levels.
Objective To compare the diagnostic performance of three rapid antigen detection tests (RADTs) for group A Streptococcus (GAS). Design hospital-based, cross-sectional, retrospective study. Setting comparative study GAS using clinical specimens in a single institute. Participants 225 children outpatient clinics ofKorea University Guro Hospitalwith suspicious symptoms were subjected to throat swab sampling. dual-swab applicator was used. Samples stored at below −70°C 10 mL transport tube...
혈구포식 림프조직구증(hemophagocytic lymphohistiocytosis, HLH)은 활성화된 림프구와 포식성 조직구가 골수, 중추 신경계, 간, 비장 등에 광범위하게 침윤하여 혈구가 파괴되는 단핵구 탐식 체계의 반응성 질환이다. HLH은 상염색체 열성으로 유전하는 원 발성 HLH와 감염, 면역질환 및 악성종양과 연관되어 유발되는 속 HLH로 분류된다. 국내에서 최근 20년간 보고된 대부분은 감 염질환과 연관된 속발성 HLH였으며[1], 이들 중 바이러스 감염에 의한 것이 30%로 가장 많았고, 그 절반 이상에서 ebstein-barr virus (EBV) 감염이 보고되었다[2, 3]. 그러나 위의 증례들 대부분이 클론성 염색체이상을 보인 림프조직구증 1예 A Case of Hemophagocytic Lymphohistiocytosis with Clonal Karyotype Abnormalities
Gene expression analysis facilitates the detection of diagnostic and prognostic biomarkers for myeloid haematological malignancies. The Oncomine Myeloid Research Assay (OMA; Thermo Fisher Scientific, Massachusetts, USA) provides a comprehensive gene five target genes, along with alteration fusion. Here, we present performance OMA analysis.In total, 53 RNA samples from patients diagnosed acute leukaemia (AML) or myelodysplastic syndrome were included. Of these samples, 3 evaluated...
Assessment of bone marrow involvement (BMI) in non-Hodgkin lymphoma (NHL) is crucial for determining patient prognosis and treatment strategy. We assessed the prognostic value next-generation sequencing (NGS)-based immunoglobulin (Ig) gene clonality analysis as an ancillary test BMI evaluation NHL.
The accuracy of Logical Observation Identifiers Names and Codes (LOINC) mappings is reportedly low, the LOINC codes used for research purposes in Korea have not been validated or usability. Our study aimed to evaluate discrepancies similarities interoperability using existing actual patient care settings. We collected data on local test their corresponding from seven university hospitals. analysis focused laboratory tests that are frequently requested, excluding clinical microbiology...
Abstract Background Capillary blood is the most commonly used sample for point‐of‐care (POC) glucometers. However, in critically ill patients, glucose levels measured from capillary may not be reliable. Thus, we aimed to evaluate and compare accuracy of with POC glucometers YSI 2300 analyzer using leftover arterial samples. Methods In total, 100 heparinized samples were performance three i‐SENS (BAROzen H Expert plus, CareSens PRO, Beat) ACCU‐CHEK ® Inform II glucometer. The reference value...
Homocysteine, a risk factor for cardiovascular disease, is commonly analyzed using enzymatic measurements and immunoassays. We compared the results of new assay with those an immunoassay, reagents homocysteine. The 87 serum samples were Abbott Architect i2000sr (immunoassay) Toshiba TBA-c16000 (enzymatic assay), obtained from two assays precision, correlation, linearity, sample carryover, reference range verification according to Clinical Laboratory Standards Institute guidelines....
The accuracy of point-of-care blood glucometers in the detection and evaluation neonatal hypoglycemia is a concern. This study compared performance three i-SENS with that YSI 2300 STAT Plus Analyzer, which was used as reference.The leftover capillary samples 319 patients were this study. process criteria based on International Organization for Standardization 15197:2013 guidelines. involved (BAROzen H Expert plus, CareSens PRO, Beat) ACCU-CHEK® Inform II glucometer.The yielded acceptable...
This study aimed to identify and examine the effects of weight control behaviors correlated with loss in obese individuals who attempted lose within past year.
The Norudia glycated albumin (GA) assay was evaluated for analytical performance and applicability on multiple platforms.The evaluation included precision, linearity, reference interval, comparison with Lucica GA assay. A multicenter study conducted to compare the results of five kinds widely used automated clinical chemistry analyzers.Within-laboratory imprecisions GA% presented 1.3 - 3.3% 0.8 2.6% low- high-level control materials, respectively, different analyzers. linear from 20.0 680.0...
eISSN 2093-6338 치료가 가능하게 할 수 있도록 하기 위해서는 HIV 조기진단이 매 우 중요하다. 감염 후 항체가 출현하기 전까지의 혈청전환 창 기간(window period)을 줄이기 위해 p24 항원과 HIV-1, -2 항체를 동시에 검출하는 제4세대 검사가 개발되어 1997년 소개되면 서 기존의 3세대 시약보다 4-8일 정도 일찍 검출이 가능 하다는 보고가 이어졌다[1, 2]. 또한, 검사와 비교하여 4 세대 검사의 민감도가 우월하다는 국내외 여러 있었 고 4세대 검사법의 경우도 시약에 따라 민감도는 98.1-100%, 특이도는 98-100%로 다양하다[3-11]. 최근에 유럽 성병클리닉과 WHO에서는 조기진단을 스크리닝검사를 사 용할 것을 권장하고 있다[12, 13]. 최근 시약인 Elecsys Ag/Ab Combi (Roche Diagnostics GmbH, Penzberg, Germany) 기능을 향상시킨 combi PT Ger서 론