A5113880318- Pulmonary Hypertension Research and Treatments
- Liver Disease and Transplantation
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Supply Chain and Inventory Management
- Galectins and Cancer Biology
- High Altitude and Hypoxia
- COVID-19 and Mental Health
- Topic Modeling
- Manufacturing Process and Optimization
- Dietary Effects on Health
- COVID-19 Clinical Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Environmental Changes in China
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- COVID-19 epidemiological studies
- Sphingolipid Metabolism and Signaling
- Additive Manufacturing and 3D Printing Technologies
- Scoliosis diagnosis and treatment
- Regulation of Appetite and Obesity
- Immune cells in cancer
- Forecasting Techniques and Applications
- Natural Language Processing Techniques
- Digital Transformation in Industry
- PI3K/AKT/mTOR signaling in cancer
- Remote Sensing and Land Use
East China Normal University
2021-2025
Beijing University of Chinese Medicine
2024
Huazhong University of Science and Technology
2019-2023
Union Hospital
2019-2021
Union Hospital
2019-2021
Wuhan Union Hospital
2020
Wenzhou Medical University
2018
Purpose The dissemination of 3D printing is contingent upon the strategic formulation innovative business models that are integrated with supply chain management. While considered a disruptive innovation has simultaneously transformed and operations, previous research often treated these two aspects separately. To bridge this gap, paper aims to explore alignment between model operations enhance proliferation technology. Design/methodology/approach This study integrates manufacturer-...
Pulmonary artery hypertension (PAH) is an incurable disease with a high mortality rate. Current medications ameliorate symptoms but cannot target adverse vascular remodeling. New therapeutic strategies for PAH need to be established.Using the weighted gene coexpression network analysis (WGCNA) algorithm, we constructed of dataset GSE117261 from Gene Expression Omnibus (GEO) database. Key modules were identified by relationship between module eigengenes and clinical traits. Hub genes screened...
The excessive and ectopic pulmonary artery smooth muscle cells (PASMCs) are crucial to the pathogenesis of arteriole (PA) remodeling in arterial hypertension (PAH). We previously found that microRNA (miR)-30a was significantly increased acute myocardial infarction (AMI) patients animals, as well cultured cardiomyocytes after hypoxia, suggesting it might be strongly associated with hypoxia-related diseases. Here, we investigated role miR-30a PASMC PAH. expression higher serum PAH compared...
Background: Numerous pieces of evidence have indicated that thoracic aortic dissection (TAD) is an inflammatory disease. Sphingosine-1-phosphate receptor 2 (S1PR2) signaling a driver in multiple diseases. Here, we examined the S1PR2 expression TAD lesions and explored effect interfering with on formation progression. Methods: Aorta specimens blood samples were collected from patients matched controls. The S1PR1, S1PR2, S1PR3 was examined. inhibiting evaluated mouse model induced by...
Background: Previously, we invented a therapeutic vaccine targeting the endothelin-A receptor (termed ETRQβ-002). ETRQβ-002 successfully prevented remodeling of pulmonary arterioles (PAs) and right ventricle (RV) without significant immune-mediated damage in experimental arterial hypertension (PAH) mice models. Objective: Here, aim to further evaluate long-term effects ETRQβ-002. Methods: PAH model was induced by combination subcutaneous injection with Sugen5416 chronic hypoxic conditions...
To find the sexual reproduction characteristics and improve seed propagation new variety breeding of Fritillaria cirrhosa.Flower, anther pistil development were observed. Pollinating in different period bagging used to measure stigma maturity situation natural outcrossing rate.It took 12 days from floral bud emergency finished flowering. It was observed that opened longitudinal direction pollen ejected for 2-4 continuously. Pistil matured earlier, chapiter could be fertilized middle stage...
The angiotensin II type 1 receptor (AT1R) signaling pathway is reported to modulate glucose metabolism. Targeting AT1R, our group invented ATRQβ-001 vaccine, a novel immunotherapeutic strategy block the activation of AT1R. Here, we evaluated therapeutic efficacy vaccine in insulin resistance, and investigated mechanism. Our results showed that specific monoclonal antibody against epitope ATR-001 (McAb-ATR) decreased fasting serum concentration improved tolerance ob/ob mice. These beneficial...
This study aimed to assess the feasibility of home-based kyphosis-specific exercises among Chinese older adults with different exercise habits and explore its potential effects on reducing kyphosis angle improving physical performance.A single-group, pre-and post-test design was conducted according CONSORT 2010 statement: extension for pilot trials. A total 20 participants aged ≥60 thoracic hyperkyphosis rehabilitation were recruited from four local communities in Wuhan, China. Participants...
Since December 2019, coronavirus disease (COVID-19) has affected over 50 000 people in Wuhan, China. However, the number of daily infection cases, hospitalization rate, lag time from onset to diagnosis date and their associations with measures introduced slow down spread COVID-19 have not been fully explored.This study recruited 6872 patients Wuchang district, Wuhan. All had an 21 2019 23 February 2020. The overall weekly rate were calculated. infections was estimated by back-projection...
As Large Language Models (LLMs) grow increasingly adept at managing complex tasks, the evaluation set must keep pace with these advancements to ensure it remains sufficiently discriminative. Item Discrimination (ID) theory, which is widely used in educational assessment, measures ability of individual test items differentiate between high and low performers. Inspired by this we propose an ID-induced prompt synthesis framework for evaluating LLMs can continually update refine according model...
<i>Background </i>Breast nodules are a health issue that concerns women, and clinical practice entails great concern for accurate diagnosis appropriate prevention treatment. This study examined the correlation between ultrasound manifestations traditional Chinese medicine (TCM) syndrome differentiation of breast nodules. <i>Methods </i>This included 128 patients with based on ultrasound-dependent Breast Imaging-Reporting Data System...
To investigate the effect of Yiqi Wenyang Huoxue Huatan Fang (YWHHF) on alleviating hypoxia-hypercarbia pulmonary hypertension by inhibiting endothelial-mesenchymal transition (EndoMT) via BMP-7/Smads pathway.Fifty male healthy SD rats clean grede, weighting (180~220) g, were randomly divided into 5 groups (n=10):normoxia group (N), (HH); YWHHF high dose (YH), middle (YM) and low (YL). The in N kept normal oxygen environment, remaining four intermittently exposed to environment (9%~11% O2,...