A5047294116- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Urinary Bladder and Prostate Research
- Kidney Stones and Urolithiasis Treatments
- Hormonal and reproductive studies
- Pelvic floor disorders treatments
- Pediatric Urology and Nephrology Studies
- Therapeutic Uses of Natural Elements
- Cancer, Lipids, and Metabolism
- Sexual function and dysfunction studies
- Urinary Tract Infections Management
- Estrogen and related hormone effects
- Bone health and treatments
- Genital Health and Disease
- Paleopathology and ancient diseases
- Bladder and Urothelial Cancer Treatments
- Urologic and reproductive health conditions
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Bone health and osteoporosis research
- Renal function and acid-base balance
- Comparative and International Law Studies
- Dialysis and Renal Disease Management
- Medical Imaging and Pathology Studies
- Cancer Diagnosis and Treatment
Federico II University Hospital
2006-2024
University of Naples Federico II
2014-2024
Polytechnic University of Turin
2024
Azienda Ospedaliera Universitaria Integrata Verona
2007
We evaluated the prevalence and estimated incidence risk factors of chronic prostatitis/chronic pelvic pain syndrome in urological hospital outpatients Italy.From January to June 2006 patients from 28 Italian centers who were between 25 50 years old with symptoms consecutively enrolled this prospective epidemiological case-control study. A total 152 subjects similar age, race area origin investigated for infertile couples but otherwise healthy served as controls. All provided a medical...
: Multiparametric magnetic resonance is an established imaging utilized in the diagnostic pathway of prostate cancer. The aim this study to evaluate accuracy and reliability multiparametric (mpMRI) detection clinically significant cancer, defined as Gleason Score ≥ 4 + 3 or a maximum cancer core length 6 mm longer, patients with previous negative biopsy.
Galectin-1 and galectin-3 are galactoside-binding proteins involved in different steps of tumor progression potential targets for therapy. We have investigated the expression these galectins 38 human bladder transitional-cell carcinomas histological grade clinical stage 5 normal urothelium samples. mRNA levels were highly increased most high-grade tumors compared with or low-grade tumors. Western blot immuno-histochemical analysis neoplastic tissues revealed a higher content galectin-1...
OBJECTIVE To validate the Italian version of two questionnaires for lower urinary tract symptoms (LUTS), i.e. long (LF) and short form (SF) International Consultation on Incontinence Questionnaire (ICIQ). METHODS Two native speakers a English speaker collaborated with clinical investigators through multistep process to obtain consensus questionnaires. The resulting versions were then pre‐tested during pilot study 16 women LF 10 SF. final ICIQ‐LF ICIQ‐SF administered samples consecutive...
A new family of angiogenic factors named endocrine-gland-derived vascular endothelial growth (EG-VEGF)/prokineticins (PK) have been recently described as predominantly expressed in steroidogenic tissues. Whether the normal and malignant epithelial prostate cells tissues express EG-VEGF/PK1 PK2 their receptors is still unknown. We studied expression (PK-R1 PK-R2) human involvement cancer. Using immunohistochemistry, Western blot, RT-PCR, we determined (NP) (PCa), cell primary cultures from...
Over the past years laser technology has played a predominant role in prostate surgery, for treatment of benign hypertrophy (BPH). Various devices have been introduced clinical practice, showing good results terms complications and urodynamic outcomes efficacy compared with TURP Open Prostatectomy. In this study we describe safety profile novel technique, ThuLEP (Thulium Laser Enucleation Prostate) that permits complete anatomical endoscopic enucleation prostatic adenoma independently to...
<i>Objectives:</i> To assess the effect of neoadjuvant hormone treatment before radical prostatectomy on: tumor/prostate volume, prostate-specific antigen (PSA) and testosterone levels, surgical margin status tumor stage, ease surgery following treatment. <i>Methods:</i> Patients with clinically localized prostatic carcinoma were randomized to receive leuprolide acetate depot 3.75 mg once a month for 3 months cyproterone 300 week weeks prior (group A). A control group...
Prostatic cancer may remain organ-confined indefinitely; in a number of patients, however it gives rise to clinical symptoms and death. The biological behaviour this tumour mostly remains difficult predict. A promising tool for diagnosis prognosis some human tumours is the chromatin assembly factor-1 (CAF-1), involved control higher order organization. aim was explore role CAF-1/p60 protein as new prognostic marker prostatic cancer.The expression evaluated by immunohistochemistry Western...
Objectives: Worldwide the urolithiasis is third most frequent urological disease affecting both males and females. In literature there are not recent Italian epidemiological data about stone disease. The objective of this study evaluation current epidemiology in Italy using Health Search/CSD Longitudinal Patient Database (HS) database. Material methods: An observational, descriptive, retrospective trial was conducted. Inclusion criteria were: family physician- assisted living population...
Coronaviruses (CoVs) are a group of RNA viruses involved in several human diseases affecting respiratory, enteric, hepatic, and neurological systems. COVID-19 was identified 2020 named SARS-CoV-2. To limit worldwide contagion, many countries instituted lockdown, which conducted to disruption routine life. In fact, pandemic associated with stresses among population, such as loss employment, deaths family members, friends, or colleagues, financial insecurity, isolation. This led long-lasting...
To evaluate whether a dose of 50 mg preserved the architecture corpora cavernosa biopsy in man.21 patients (54-70 years old) who underwent radical prostatectomy for prostate cancer were treated with sildenafil citrate (50 mg, 3 times week 2 months) soon after surgery. They cavernous before surgery and months treatment. Biopsy tissues fixed formalin, stained Masson's trichrome method, evaluated Eureka Interface system per-area analysis, elastic fibers counted on 10-12 fields (x400) five...
Abstract Raloxifene (RAL), a selective estrogen receptor (ER) modulator (SERM) seems to induce apoptosis in both androgen‐dependent and ‐independent prostate cell (PC) lines via activation of ERβ an antagonistic effect on ERα. In this study, we evaluated the effects RAL epithelial PC growth using two following vitro models: line EPN which expressed ERs; stabilized derived from cancer specimen (CPEC), low levels lacked cells, there was increase pre‐G1 apoptotic peak reduction S phase cycle...
The primary goal in the management strategy of a patient with ED would be to determine its etiology and cure it when possible, not just treat symptoms alone. One new therapeutic strategies is use low intensity extracorporeal shockwave (LISW) therapy. mechanism therapy completely clear. It suggested that LISW induces neovascularization improvement cavernosal arterial flow which can lead an erectile function by releasing NO, VEGF PCNA. Materials Methods: 31 patients between February June 2013...
The transcripts of five SRIH receptor subtypes (SSTR1, SSTR2, SSTR3, SSTR4, and SSTR5) were investigated by RT-PCR in epithelial cells (EC) stromal (SC) from primary cultures normal human prostates six prostate cancers. Primary EC established serum-free keratynocyte medium with 5% FCS, epidermal growth factor, bovine pituitary extract; SC cultured MEM 10% FCS. Total RNA was extracted using a modified guanidine thiocyanate method. performed after deoxyribonuclease treatment, SSTR1-, SSTR2-,...
The inguinal hernia is one of the most common diseases in elderly. Treatment this type pathology exclusively surgical and relies almost always on use local anesthesia. While past surgery was carried out mainly by general anesthesia, recent years there has been growing emphasis role aim our study to compare intra-and postoperative analgesia obtained levobupivacaine compared with that bupivacaine. Bupivacaine main anesthetics used intervention hernioplasty. Levobupivacaine an enantiomer...
Abstract Introduction We studied the possible correlation between age, testosterone deficiency, cavernosal fibrosis and erectile dysfunction (ED). Methods 47 patients with ED were enrolled September 2010 October 2011. IIEF-EF score, NPTR test using Rigiscan method, total free levels, cavernosum biopsy carried out on all patients. Patients aged 65 or over defined as Old Age (OA) while under Young age (YA). The strength of relationships found was estimated by Odds Ratio. Results 74% values 52%...