A5051145438- Nanoplatforms for cancer theranostics
- Protein Degradation and Inhibitors
- Sulfur Compounds in Biology
- Perovskite Materials and Applications
- Ubiquitin and proteasome pathways
- Photoacoustic and Ultrasonic Imaging
- Antimicrobial Peptides and Activities
- Multiple Myeloma Research and Treatments
- Histone Deacetylase Inhibitors Research
- Advanced biosensing and bioanalysis techniques
- Supramolecular Self-Assembly in Materials
- Advanced Fluorescence Microscopy Techniques
- Inhalation and Respiratory Drug Delivery
- Optical Imaging and Spectroscopy Techniques
- CAR-T cell therapy research
- Heat shock proteins research
- RNA Interference and Gene Delivery
- Click Chemistry and Applications
- Photoreceptor and optogenetics research
- Bacteriophages and microbial interactions
- Software Testing and Debugging Techniques
- Dental Research and COVID-19
- bioluminescence and chemiluminescence research
Innovative Genomics Institute
2024
University of California, Berkeley
2024
Nanyang Technological University
2020-2022
Targeted protein degradation with monovalent molecular glue degraders is a powerful therapeutic modality for eliminating disease causing proteins. However, rational design of remains challenging. In this study, we sought to identify transplantable and linker-less covalent handle that could be appended onto the exit vector various protein-targeting ligands induce their respective targets. Using BET family inhibitor JQ1 as testbed, synthesized screened series analogs identified vinylsulfonyl...
Abstract Real‐time monitoring of the evolution bacterial infection‐associated multiple radical species is critical to accurately profile pathogenesis and host‐defense mechanisms. Here, we present a unique dual wavelength near‐infrared (NIR) cyanine‐dyad molecular probe (HCy5‐Cy7) for simultaneous reactive oxygen nitrogen (RONS) variations both in vitro vivo. HCy5‐Cy7 specifically turns on its fluorescence at 660 nm via superoxide or hydroxyl (O 2 .− , . OH)‐mediated oxidation reduced HCy5...
Epigenetic mediation through bromodomain and extraterminal (BET) proteins have progressively translated protein imbalance into effective cancer treatment. Perturbation of druggable BET proteolysis-targeting chimeras (PROTACs) has recently contributed to the discovery therapeutics. Unfortunately, precise microenvironment-activatable degradation content with promising tumor selectivity pharmacological suitability remains elusive. Here, we present an enzyme-derived clicking PROTACs (ENCTACs)...
Subcellular localization of nanoparticles plays critical roles in precision medicine that can facilitate an in-depth understanding disease etiology and achieve accurate theranostic regulation via responding to the aiding stimuli. The photothermal effect is extensively employed strategy converts light into heat stimulation induce localized ablation. Despite diverse manipulations have been investigated nanotheranostics, influences nanoheaters' subcellular distribution their molecular mechanism...
In situ self-assembly has attracted increasing research interest for applications in imaging and therapy recent years. Particularly protease-activated developments, inspiration is drawn from the innate specificity of their catalytic activities, rapid discovery various roles they play proliferation certain diseases, inherent susceptibility small molecule peptide conjugates to proteolytic digestion vivo. The overexpression a disease-related protease can be exploited as an endogenous stimulus...
Abstract Targeted protein degradation with monovalent molecular glue degraders is a powerful therapeutic modality for eliminating disease causing proteins. However, rational design of remains challenging. In this study, we sought to identify transplantable and linker-less covalent handle that could be appended onto the exit vector various protein-targeting ligands induce their respective targets. Using BET family inhibitor JQ1 as testbed, synthesized screened series analogs identified...
Abstract Real‐time monitoring of the evolution bacterial infection‐associated multiple radical species is critical to accurately profile pathogenesis and host‐defense mechanisms. Here, we present a unique dual wavelength near‐infrared (NIR) cyanine‐dyad molecular probe (HCy5‐Cy7) for simultaneous reactive oxygen nitrogen (RONS) variations both in vitro vivo. HCy5‐Cy7 specifically turns on its fluorescence at 660 nm via superoxide or hydroxyl (O 2 .− , . OH)‐mediated oxidation reduced HCy5...
As an essential signalling mediator, multiple redox radicals, including reactive oxygen and nitrogen species (ROS/RNS), have been extensively authenticated as significant functional regulators involved in many physiological processes such cellular signal transduction, intermediary metabolism, pathogenesis, well immune or inflammatory response.The altered balances may cause severe oxidative nitrosative stress that is closely implicated the etiology pathologies of diverse human diseases...