A5079818501- Antibiotics Pharmacokinetics and Efficacy
- Free Radicals and Antioxidants
- Liver Disease Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Smoking Behavior and Cessation
- Drug Solubulity and Delivery Systems
- Enzyme Catalysis and Immobilization
- Antibiotic Resistance in Bacteria
- Liver Disease and Transplantation
- Bacterial Identification and Susceptibility Testing
- Advanced Fluorescence Microscopy Techniques
- Synthesis and Catalytic Reactions
- Antibiotic Use and Resistance
- Chemical synthesis and alkaloids
- Cyclopropane Reaction Mechanisms
- Analytical Methods in Pharmaceuticals
- Traditional and Medicinal Uses of Annonaceae
- Electroconvulsive Therapy Studies
- Catalytic Cross-Coupling Reactions
- Antifungal resistance and susceptibility
- Pesticide Exposure and Toxicity
- Takotsubo Cardiomyopathy and Associated Phenomena
- Enzyme Structure and Function
- Optical Imaging and Spectroscopy Techniques
- Analytical Chemistry and Chromatography
Montclair State University
2018
University of South Australia
2009-2017
Basil Hetzel Institute
2012-2015
Queen Elizabeth Hospital
2014-2015
Princess Alexandra Hospital
2008-2012
The University of Queensland
2004-2012
University of Warwick
2004
Emory University
2004
Australian National University
1998-2003
University of Southampton
2000
To compare the plasma and subcutaneous tissue concentration–time profiles of meropenem administered by intermittent bolus dosing or continuous infusion to critically ill patients with sepsis without renal dysfunction, use population pharmacokinetic modelling Monte Carlo simulations assess cumulative fraction response (CFR) against Gram-negative pathogens likely be encountered in critical care units. We randomized 10 receive administration (n = 5; 1 g 8 hourly) an equal dose 5). Serial...
Emerging evidence supports the use of therapeutic drug monitoring (TDM) β-lactams for intensive care unit (ICU) patients to optimize exposure, although limited detail is available on how sites run this service in practice. This multicentre survey study was performed describe various approaches used β-lactam TDM ICUs. A questionnaire developed aspects relating conduct an ICU setting. Data sought included: chosen TDM, inclusion criteria selecting patients, blood sampling strategy, analytical...
To describe a pharmacokinetic model of piperacillin concentrations in plasma and subcutaneous tissue when administered by bolus dosing continuous infusion critically ill patients with sepsis on days 1 2 antibiotic therapy to compare results against previous for from cohort septic shock.Prospective randomized controlled trial.Eighteen-bed intensive care unit at 918-bed tertiary referral hospital.Thirteen adult known or suspected whom the treating physician deemed piperacillin-tazobactam...
Deliberate self-poisoning with older pesticides such as organophosphorus compounds are commonly fatal and a serious public health problem in the developing world. The clinical consequences of newer not well described. Such information may help to improve management inform pesticide regulators their relative toxicity. This study reports outcomes toxicokinetics neonicotinoid insecticide imidacloprid following acute humans.Demographic data were prospectively recorded patients exposure three...
Abstract Multiphoton tomography was used to examine xenobiotic transport in vivo . We the photochemical properties of zinc oxide and fluorescein multiphoton study their skin rat liver Zinc nanoparticles were visualised human using photoluminescence either a selective emission wavelength band pass filter or with fluorescence lifetime imaging (FLIM). (30 nm) did not penetrate into vitro this validated by scanning electron microscopy X‐ray photoelectron spectroscopy. Fluorescein measured FLIM....
α-Helices are key structural components of proteins and important recognition motifs in biology. Short peptides (≤15 residues) corresponding to these helical sequences rarely away from their stabilizing protein environments. New techniques for short peptide helices could be valuable studying folding, modeling proteins, creating artificial may aid the design inhibitors or mimics function. This study reports facile incorporation 3- 4-α turns 10−15 residue through formation situ multiple cyclic...
Intravital fluorescence microscopy enables the direct imaging of fluorophores in vivo and advanced techniques such as lifetime (FLIM) enable simultaneous detection multiple fluorophores. Consequently, it is now possible to record distribution metabolism a chemical optimise delivery vivo. Recent clinical applications with fluorescein other intravital fluorescent stains have occurred neurosurgery, dermatology [including photodynamic therapy (PDT)] endomicroscopy. Potential uses been identified...
ABSTRACT This study assessed the pharmacokinetics and dosing adequacy of piperacillin in febrile neutropenic patients after first dose. Pharmacokinetic analysis was performed using noncompartmental methods. We observed an elevated volume distribution (29.7 ± 8.0 liters [mean standard deviation]) clearance (20.2 7.5 liters/h) compared to data from other patient populations. Antibiotic exposure did not consistently result therapeutic targets. conclude that alternative strategies guided by drug...
Cyberloafing—the use of an electronic device at work for activity that immediate supervisor would not consider work-related—is now the most common way employees waste time work. It is well established social norms play a role in cyberloafing, but it unknown what specific normative information attend to when deciding whether or cyberloaf. In Study 1, we tested which four types could underlie observed correlation between and cyberloafing. We found both perceptions cyberloafing coworker...
To determine the history, clinicopathologic findings, and results of surgery for effusive-constrictive pericarditis associated with Coccidioides immitis infection in dogs.Retrospective study.17 client-owned dogs that underwent a subtotal pericardectomy epicardial excision.Hospital records from May 1999 to June 2003 were reviewed. Data collected included treatments, outcome. Follow-up information was obtained via recheck examination by use standardized telephone interviews referring...
2-Hydroxy-6-keto-nona-2,4-diene 1,9-dioic acid 5,6-hydrolase (MhpC) from Escherichia coli catalyses the hydrolytic cleavage of extradiol ring fission product on phenylpropionate catabolic pathway and is a member α/β hydrolase family. The catalytic mechanism this enzyme has previously been shown to proceed via initial ketonization dienol substrate (Henderson, I. M. J., Bugg, T. D. H. (1997) Biochemistry 36, 12252−12258), followed by stereospecific fragmentation. Despite implication an active...
The hepatic pharmacokinetics of five selected cationic drugs (propranolol, labetalol, metoprolol, antipyrine, and atenolol) was studied in the liver from control rats those with high-fat emulsion-induced nonalcoholic steatohepatitis (NASH). Studies were undertaken using an situ-perfused rat multiple indicator dilution, outflow data analyzed a physiologically based organ pharmacokinetic model. Hepatic extraction (<i>E</i>) significantly lower NASH model, lipophilicity main solute structural...
Multiphoton microscopy has been shown to be a useful tool in studying drug distribution biological tissues. In addition, fluorescence lifetime imaging provides information about the structure and dynamics of fluorophores based on their lifetimes. Fluorescein, commonly used fluorescent probe, is metabolized within liver cells fluorescein mono-glucuronide, which also fluorescent. Fluorescein its glucuronide have similar excitation emission spectra, but different this study, we employed...
ABSTRACT The objective of the study was to describe subcutaneous interstitial fluid (ISF) pharmacokinetics fluconazole in critically ill patients with sepsis. This prospective observational conducted at two tertiary intensive care units Australia. Serial concentrations were measured over 24 h plasma and ISF using microdialysis. microdialysate a validated high-performance liquid chromatography system electrospray mass spectrometer detector method. Noncompartmental pharmacokinetic analysis...