A5074544757- Periodontal Regeneration and Treatments
- Head and Neck Cancer Studies
- Reconstructive Surgery and Microvascular Techniques
- Oral and Maxillofacial Pathology
- Angiogenesis and VEGF in Cancer
- Bone health and treatments
- Bone and Joint Diseases
- Dental Implant Techniques and Outcomes
- Bone Tissue Engineering Materials
- Optical Imaging and Spectroscopy Techniques
- Oral Health Pathology and Treatment
- Cancer, Hypoxia, and Metabolism
- Facial Trauma and Fracture Management
- Dental Radiography and Imaging
- Cancer Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Wound Healing and Treatments
- Hemostasis and retained surgical items
- Electrospun Nanofibers in Biomedical Applications
- Oral health in cancer treatment
- Cancer Mechanisms and Therapy
- Cervical Cancer and HPV Research
- Peptidase Inhibition and Analysis
- Photoacoustic and Ultrasonic Imaging
- Salivary Gland Tumors Diagnosis and Treatment
University Medical Centre Mannheim
2020-2025
Johannes Gutenberg University Mainz
2016-2025
University Medical Center of the Johannes Gutenberg University Mainz
2016-2025
University Medical Center
2023
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2023
Tumor recurrence in oral squamous cell carcinoma (OSCC) is frequent. However, no consensus about follow-up interval available. The aim of this study was to analyze the pattern, detection method and associated parameters for possible risk stratification. Histopathological epidemiological features were obtained retrospectively correlated with tumor overall survival, distant lymph node metastases. A total 760 patients included, which 216 showed (mean after 24 ± 26 months). Within first 12...
The aim of the in vitro study was a comparison an allogenic (ABSM) and xenogenic bone substitute material (XBSM) with without injectable platelet-rich fibrin (ABSM-i-PRF & XBSM-i-PRF) on cell characteristics human osteoblasts (HOB). Here, ABSM XBSM (+ i-PRF = test; - control) were incubated HOB for 3, 7 10 days. viability, migration, proliferation differentiation (RT-PCR alkaline phosphatase (AP), morphogenetic protein 2 (BMP-2) osteonectin (OCN)) measured compared between groups. At day...
Porcine-derived collagen matrices (CM) can be used for oral tissue regeneration, but sufficient revascularization is crucial. The aim of this study was to analyze the influence platelet-rich fibrin (PRF) on angiogenesis different CM in vitro and vivo.Three (mucoderm®, jason®, collprotect®) were combined with PRF a plotting process. Growth factor release (VEGF, TGF-β) measured via ELISA quantification after 1,4 7 days comparison alone. In ovo yolk sac (YSM) chorion allantois membrane (CAM)...
In reconstructive surgery, free flap failure, especially in complex osteocutaneous reconstructions, represents a significant clinical burden. Therefore, the aim of presented study was to assess hyperspectral imaging (HSI) for monitoring flaps compared monitoring. prospective, non-randomized study, patients with reconstruction oro-maxillofacial-complex were included. Monitoring assessed clinically and by using (TIVITA™ Tissue-System, DiaspectiveVision GmbH, Pepelow, Germany) determine...
Silk fibroin (SF) is a biomaterial derived from the cocoon of mulberry silkworm. This study aimed to assess capacity SF matrices biologized with injectable platelet-rich fibrin (iPRF) or enamel matrix protein (EMP) modulate angiogenesis and immune response in chorioallantoic membrane (CAM) assay. 300 eggs were divided into following groups: CM + NaCl, iPRF, EMP, EMP. Matrices applied CAM on embryonic development day (EDD) 7 after rehydration. Angiogenesis, represented by vascularized area,...
The impaired angiogenic potential of bone substitute materials (BSMs) may limit regenerative processes. Therefore, changes in the angiogenetic properties different BSMs combination with platelet-rich fibrin (PRF) comparison to PRF alone, as well native BSMs, were analyzed vitro and vivo evaluate possible clinical application. In vitro, four origins (allogeneic, alloplastic, xenogeneic) biofunctionalized compared terms platelet interaction growth factor release (vascular endothelial (VEGF),...
Introduction The aim of the in vitro study was to compare effect four bovine bone substitute materials (XBSM) with and without injectable platelet-reach fibrin for viability metabolic activity human osteoblasts (HOB) as well expression alkaline phosphatase (ALP), morphogenetic protein 2 (BMP-2), osteonectin (OCN). Materials Methods Cerabone ® (CB), Bio-Oss (BO), Creos Xenogain (CX) MinerOss X (MO) ± i-PRF were incubated HOB. At day 3, 7, 10, cell ALP, OCN, BMP-2, examined. Results For...
Bone substitute materials (BSM) are widely used in oral regeneration, but sufficient angiogenesis is crucial for osteogenesis. The combination of BSM with autologous thrombocyte concentrations such as platelet-rich fibrin (PRF) may represent a clinical approach to overcome this limitation. This study analyzes the early influence on osteoblast (HOB) vitro . Here, four different (allogeneic, alloplastic, and two xenogeneic origin) were combined PRF. After incubation osteoblasts 24 h, cell...
Abstract Objectives Pre-vascularization of the collagen membranes with autologous platelet concentrates is a standard procedure in oral and maxillofacial surgery. This study analyzed possible interaction an acellular membrane porcine origin (NM) platelet-rich fibrin (PRF) regarding its rehydration protocol differences pH values effect on angiogenesis. Materials methods NM was alone combined solid PRF by plotting or co-culturing injectable PRF. Different media (venous blood, buffer solution...
Introduction: Autologous platelet concentrate (APC) are pro-angiogenic and can promote wound healing tissue repair, also in combination with other biomaterials. However, challenging defect situations remain demanding. 3D bioprinting of an APC based bioink encapsulated a hydrogel could overcome this limitation enhanced physio-mechanical interface, growth factor retention/secretion defect-personalized shape to ultimately enhance regeneration. Methods: This study used extrusion-based create...
Background Inflammation and cell‐mediated immunity have a key role in different stages of carcinogenesis. The aim this prospective study was to assess serum levels proinflammatory cytokines interleukin‐6 ( IL ‐6), interleukin‐8 ‐8), soluble interleukin‐2 receptor sIL ‐2R), tumor necrosis factor alpha TNF ‐α), MHC class I polypeptide‐related sequence B MICB ) patients with oral premalignant lesion OPL ), squamous cell carcinoma OSCC healthy controls multi‐biomarker approach as potential...
Introduction: The effective induction of angiogenesis is directly related to the success bone-substitute materials (BSM) for maxillofacial osseous regeneration. Therefore, addition pro-angiogenic properties a commercially available bovine material in combination with hyaluronic acid (BSM+) was compared same without an in-vivo model. Materials and Methods: BSM+ BSM were incubated six days on chorioallantoic membrane (CAM) fertilized chicken eggs. Microscopically, number vessels branching...
Improved serological biomarkers are needed for the early detection, risk stratification and treatment surveillance of patients with oral squamous cell carcinoma (OSCC). We performed an exploratory study using advanced, highly specific, DNA-aptamer-based serum proteomics (SOMAscan, 1305-plex) to identify distinct proteomic changes in OSCC pre- vs. post-resection compared healthy controls. A total 63 significantly differentially expressed proteins (each p < 0.05) were found that could...
Medication-related osteonecrosis (MRONJ) of the jaw is a severe and feared side effect antiresorptive therapy in oncological setting. With growing evidence that impaired angiogenesis may represent key factor pathogenesis, aim this study was to evaluate an autologous platelet concentrate as possible additive surgical optimize vascularization and, subsequently, resolution rates.A non-interventional, prospective, multicenter conducted, all patients with stage I-III MRONJ, undergoing for...
This clinical prospective randomized controlled study aimed to investigate the differences between Radial (RFFF) and Ulnar (UFFF) Forearm Free Flap in terms of success, performance, donor site morbidity. Thirty patients with reconstruction head neck region were included. For first time, this assessed flap-perfusion characteristics, donor-site-wound-healing dynamics hand perfusion using hyperspectral imaging. Further, subjective (Likert-scale, DASH-score) objective (grip/pinch-strength)...
Since the first description of bisphosphonate-related osteonecrosis jaw (BRONJ), numerous research groups have focused on possible pathological mechanisms including suppression bone turnover jaw, antiangiogenic effects and soft tissue toxicity. In our review we summarizing role tissues in development progression BRONJ. The biological behavior fibroblasts can be significantly influenced by bisphosphonates (BP) such as a concentration dependent reduction cell viability. High concentrations BP...