A5068255766- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthetic Organic Chemistry Methods
- Carbohydrate Chemistry and Synthesis
- Asymmetric Synthesis and Catalysis
- Crystallography and molecular interactions
- Oxidative Organic Chemistry Reactions
- Synthesis of Organic Compounds
- Chemical Synthesis and Analysis
- Microbial Natural Products and Biosynthesis
- Electron Spin Resonance Studies
- Traditional and Medicinal Uses of Annonaceae
- Plant biochemistry and biosynthesis
- Silicone and Siloxane Chemistry
- Synthesis and Biological Evaluation
- Chemical synthesis and alkaloids
- Catalytic C–H Functionalization Methods
- Olfactory and Sensory Function Studies
- Catalytic Alkyne Reactions
- Synthesis and characterization of novel inorganic/organometallic compounds
- Boron Compounds in Chemistry
- Synthesis and properties of polymers
- Fluorine in Organic Chemistry
- Organometallic Complex Synthesis and Catalysis
- Biochemical Analysis and Sensing Techniques
Slovak University of Technology in Bratislava
2012-2023
ETH Zurich
2004
University of Cambridge
1999
University of Oxford
1999
Veszprémi Érseki Hittudományi Fõiskola
1985
The 2,6-disubstituted piperidine alkaloids (+)-dihydropinidine (1), (−)-epidihydropinidine (2) (as HCl salts), and (−)-pinidinone (3) were efficiently synthesized from (S)-epichlorohydrin (7) as common substrate using regioselective Wacker−Tsuji oxidation of alkenylazides 10 14 well a highly diastereoselective reduction cyclic imine 11 key steps. protecting group free total syntheses represent the up to date shortest routes with highest overall yields for all three naturally occurring (1−3)....
1-(Benzyloxycarbonylamino)-hex-5-en-3-ol undergoes a novel Pd(II)/CuCl2-catalysed bicyclisation to furnish the corresponding 6-oxa-2-azabicyclo[3.2.1]octane in good yield.
Bi(OTf)3·nH2O was found to be an efficient promoter of the cyclisative hydroamination unactivated alkenyl sulfonamides, giving rise N-protected 2-methyl pyrrolidines in good excellent yields (up 95%). Based on control experiments, a joint Lewis acid–Brønsted acid catalysis might operation, or triflic itself, generated situ by hydrolysis metal triflate, could true catalyst.
The first total synthesis of erythroskyrine, a polyenoyltetramic acid mycotoxin and principal pigment Penicillium Islandicum Sopp., is described using palladium(II) catalysed oxycarbonylation to create the furan-derived bicyclic portion 3 phosphonate ester 5 furnish both polyenoyl chain N-methyl(S)-valine derived tetramic terminus.
A comparison set of mono-/biradical TEMPO derivatives was prepared, novel compounds were fully characterized, and their physicochemical properties determined. Cyclic voltammetry revealed reversible redox behavior for all studied nitroxides. Moreover, the electron-withdrawing substituents increased oxidation potential respective nitroxides in to electron-donating groups. While EPR spectra monoradicals dichloromethane at 295 K reveal expected three-line signal, biradicals show more complex...
Novel piperidine lactones 1 and 2, which represent direct precursors to the new C-6 homologues of 1-deoxynojirimycin (3) 1-deoxy-L-idonojirimycin 4, were prepared by key PdII-catalysed aminocarbonylation protected aminoalkene 10.
Abstract The synthesis of C ‐mannosyl‐guanosine 23 , an advanced intermediate for the preparation stable analogues guanofosfocin, is described. This convergent approach features improved Traube ‐type a 8‐substituted guanine, followed by ribosylation. NMR Studies show that ‐mannopyranosyl moiety adopts distorted 1 4 conformation while nucleoside predominantly syn ‐oriented.
Novel TEMPO and PROXYL derivatives reveal (quasi)reversible redox behavior. The EWG-substituents increase their oxidation potential in comparison to the EDG-groups. Unlike pyrrolidinyl derivatives, piperidinyl nitroxides inhibit growth of<italic>Staphylococcus</italic>sp.
Diastereofacial selectivity of the addition organometallic reagents to 1,2-Oisopropylidene-O-R-α-D-xylopentodialdo-1,4-furanoses (6) was studied.
Abstract A series of polynitroxide amides possessing 2,2,5,5‐tetramethyl‐1‐pyrrolidinyloxy (PROXYL) and/or 2,2,6,6‐tetramethyl‐1‐piperidinyloxy (TEMPO) units connected through various bridges were synthesized and their properties analyzed. EPR spectroscopy provided detailed insight into paramagnetic character related properties. thorough examination the spectra dinitroxides in organic solvents valuable information on intramolecular motions, thermodynamics, spin‐exchange mechanisms. Analysis...
The stereoselective palladium-catalysed cyclocarbonylation of hex-5-ene-1,4-diols affords <i>cis</i>-fused bicyclic lactones only. Ring-opening with <i>N</i>,<i>O</i>-dimethylhydroxylamine hydrochloride gives the corresponding Weinreb amides, and their subsequent recyclisation provides advanced synthons for prospective synthesis decarestrictine L. relative configurations all prepared tetrahydropyrans are determined by NOESY. attempted transformations into methyl ketones leads to an...
The advantageous properties of ethylene glycol diacetate (EGDA) qualify it as a useful substitute for glycerol triacetate (GTA) various green applications. We scrutinised the lipase-mediated acetylation structurally diverse alcohols in neat EGDA furnishing range naturally occurring fragrant acetates. found that such enzymatic system exhibits high reactivity and selectivity towards activated (homo) allylic non-activated primary/secondary alcohols. This feature was utilised scalable multigram...