A5087600111- Heart Rate Variability and Autonomic Control
- Liver Disease Diagnosis and Treatment
- Stress Responses and Cortisol
- COVID-19 and healthcare impacts
- Cardiac Health and Mental Health
- Hepatocellular Carcinoma Treatment and Prognosis
- Mental Health Treatment and Access
- Neural and Behavioral Psychology Studies
- Cerebrovascular and Carotid Artery Diseases
- Hepatitis C virus research
- Cardiac, Anesthesia and Surgical Outcomes
- Mental Health Research Topics
- Blood Pressure and Hypertension Studies
- Functional Brain Connectivity Studies
- Non-Invasive Vital Sign Monitoring
- Occupational Health and Performance
- Emotion and Mood Recognition
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Cardiovascular Health and Disease Prevention
- Trauma and Emergency Care Studies
- Diabetes Management and Education
- Hepatitis B Virus Studies
- Child and Adolescent Psychosocial and Emotional Development
- Occupational Health and Safety Research
- Liver Disease and Transplantation
Baylor College of Medicine
2018-2024
Michael E. DeBakey VA Medical Center
2018-2024
Center for Innovation
2018-2024
Georgetown University
2024
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2021
Health Services Research & Development
2018-2020
The University of Texas MD Anderson Cancer Center
2013-2016
University of Pittsburgh
2008-2012
University of Pittsburgh Medical Center
2008-2010
National Institutes of Health
2010
Abstract The arterial baroreflex is a key mechanism for the homeostatic control of blood pressure (BP). In animals and humans, psychological stressors suppress capacity to short‐term fluctuations in BP, reflected by reduced sensitivity (BRS). While animal studies have characterized brain systems that link stressor processing BRS suppression, comparable human are lacking. Here, we measured beat‐to‐beat BP heart rate (HR) 97 adults who performed multisource interference task evoked changes...
In this study we investigated the effects of physical work environment on two physiological measures stress response.Circadian variations in vagally mediated heart rate variability (HRV) and morning rise cortisol were evaluated 60 participants working a government building either traditional (individual offices old cubicles; n=40) or modern workspace (individualized cubicles with improved views lighting; n=20). Results revealed significant linear (B=-1.03; confidence interval: -1.05 to...
Abstract Objective The process of cancer‐related breast reconstruction is typically multi‐staged and can take months to years complete, yet few studies have examined patient psychosocial well‐being during the process. We investigated effects timing stage on body image quality life at specific time points Methods In this cross‐sectional study, 216 patients were grouped into four reconstructive stages: pre‐reconstruction, completed 1, 2, final stages. Multiple regression analyses roles...
The understanding of the physiology hot flashes is incomplete. autonomic nervous system has been hypothesized to play a role in but received limited empirical attention. Furthermore, emerging research linked cardiovascular risk. Reduced high-frequency heart rate variability (HF-HRV), an index vagal control rate, associated with events. We that decreases HF-HRV would occur during relative periods before and after flashes.Thirty perimenopausal postmenopausal women aged 40 60 years reporting...
In Brief Objective The physiology of menopausal hot flashes is not well understood. autonomic nervous system may play a role in flashes, but the current understanding limited. We previously demonstrated laboratory that decreases high-frequency heart rate variability, an index cardiac vagal control, occur during relative to preceding and following periods. present study, we tested whether would observe similar phenomenon ambulatory setting. additionally considered respiratory these...
Summary Background Direct‐acting anti‐viral (DAA) therapy may have a beneficial role in extrahepatic manifestations of hepatitis C virus (HCV) infection. However, the available data are limited. Aim To examine effects DAA treatment on risk several HCV. Methods We conducted retrospective cohort study patients from US Department Veterans Affairs Corporate Data Warehouse who had positive HCV RNA test and received first course DAAs between 2012 2016. calculated incidence rates by sustained...
INTRODUCTION: Evaluation of academic productivity has been a cornerstone the medical research community. The Hirsch index (h-index) is popular tool for assessing in neurosurgery but associated with several limitations. National Institutes Health developed field-normalized, article-level metric, termed "relative citation ratio" (RCR), that circumvents h-index's shortcomings and attempts to assess accurately. METHODS: A retrospective cross-sectional analysis was conducted using publicly...
INTRODUCTION: Organized neurosurgery offers innumerable opportunities for scientific exchange, networking, and continuing medical education. National, regional, state, city-level societies annual meetings have rapidly proliferated across neurosurgery, with journals following suit. METHODS: state were identified, associated recorded. Top journals, as determined by reputation impact factor, selected. Data that was unavailable online acquired via direct communication the respective...
Individuals who express relatively large-magnitude or “exaggerated” blood pressure (BP) reactions to behavioral stressors are presumably at increased risk for cardiovascular disease. As shown by recent neuroimaging studies, individuals exaggerated stressor-evoked BP reactivity also heightened neural activity in corticolimbic brain areas that centrally regulate the system. These however, have exclusively examined and concomitant during stressor exposure. If originates part from a regulated...
Background & AimsThe Hepatocellular carcinoma (HCC) Early detection Screening (HES) algorithm has been proposed to improve the performance of serum alpha-fetoprotein (AFP) test in surveillance for HCC. The HES incorporates data on age, level alanine aminotransferase, platelet count, and rate AFP change increase likelihood earlier thereby reduce HCC-related mortality. We updated include etiology cirrhosis validated it a community-based cohort.MethodsWe collected from Veterans Health...
Time- and frequency-domain analyses of HRV have provided researchers with important measures cardiac vagal activity. Stationarity is theoretical importance for such in the frequency domain but may not be practical significance any particular data set. It has been argued that if a stationarity test available, it should used. On other hand, also possible RSA quite robust to nonstationarity; spectral support contention. Furthermore, procedures correct nonstationary segments compromise...
Abstract The polyvagal theory states that social behavior is linked to cardiac vagal control. This has been tested widely in infants and children, but less so adults. Thus, we examined if resting or stress‐related changes high‐frequency heart rate variability (HF‐HRV; a presumed index of control) varied with functioning 50 healthy women (mean age 68 years). After completing assessments functioning, were exposed laboratory stressors concurrent psychophysiological monitoring. Although...
Hypertension is associated with mild decrements in cognition. In addition, regional cerebral blood flow responses during memory processing are blunted parietal and thalamic areas among untreated hypertensive adults, who, compared normotensive subjects, manifest greater correlation response across task-related brain regions. Here, we test whether pharmacological treatment of hypertension normalizes it does so differentially according to drug class. Treatment lisinopril, an...
This retrospective study sought to identify patient-, provider-, and system-level characteristics associated with anxiety diagnostic specificity in mental health clinics the Veterans Health Administration. It used administrative data extracted from Veteran Administration outpatient records patients a new or trauma-related diagnosis fiscal year 2019 (N = 383,418). Logistic regression was model probability of receiving an unspecified as function characteristics. Unspecified disorder diagnosed...
The metabolic syndrome (MetS) is a clustering of cardiovascular and cerebrovascular risk factors that are often comorbid with depressive symptoms. Individual components the MetS also covary morphology basal ganglia regions altered by depression. However, it remains unknown whether covariation between symptomatology can be accounted for in part morphological changes ganglia. Accordingly, we tested hypothesis increased symptoms among individuals might statistically mediated reduced gray matter...
To extend evidence suggesting that essential hypertension influences neuropsychological performance and brain function before treatment is related to the success of pharmacological lowering blood pressure (BP).A voxel-based examination whole was conducted among 43 hypertensive patients treated for 1 year with assessment pre post treatment, using positron emission tomography testing.Neuropsychological improved over but unrelated change in regional cerebral flow (rCBF). Neither mean resting...