A5074140823- Renin-Angiotensin System Studies
- Sexual function and dysfunction studies
- Blood Pressure and Hypertension Studies
- Nitric Oxide and Endothelin Effects
- Cardiovascular Disease and Adiposity
- Protein Hydrolysis and Bioactive Peptides
- Mercury impact and mitigation studies
- Heavy Metal Exposure and Toxicity
- Biochemical effects in animals
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Erythropoietin and Anemia Treatment
- Heart Rate Variability and Autonomic Control
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hormonal Regulation and Hypertension
- Sulfur Compounds in Biology
- Gut microbiota and health
- Trace Elements in Health
- Stress Responses and Cortisol
- Parathyroid Disorders and Treatments
- Cardiovascular Health and Disease Prevention
- Metabolism, Diabetes, and Cancer
- Exercise and Physiological Responses
- Iron Metabolism and Disorders
- Receptor Mechanisms and Signaling
- Antioxidant Activity and Oxidative Stress
McMaster University
2024
Universidade Vila Velha
2022-2023
Universidade Federal do Espírito Santo
2015-2022
Escola Superior de Ciências da Santa Casa de Misericórdia de Vitória
2013
The beverage obtained by fermentation of milk with kefir grains, a complex matrix containing acid bacteria and yeasts, has been shown to have beneficial effects in various diseases. However, its on hypertension endothelial dysfunction are not yet clear. In this study, we evaluated the cells vascular responsiveness spontaneously hypertensive rats (SHR). SHR were treated (0.3 mL/100 g body weight) for 7, 15, 30 60 days compared non-treated normotensive Wistar-Kyoto rats. Vascular function was...
We previously demonstrated that iron overload induces endothelial dysfunction and oxidative stress, which could increase the risk for atherosclerosis. However, iron-related harmfulness under a genetic predisposition to atherosclerosis is still unclear. Here, we have tested hypothesis chronic may change vascular reactivity associated with worsening of atherosclerotic process in apolipoprotein E knockout (apoE(-/-)) mice.Serum aortas wild-type (WT) apoE(-/-) mice injected iron-dextran (IO, 10...
Abstract Background Atherosclerosis is an inflammatory process of the arterial walls and initiated by endothelial dysfunction accompanied imbalance in production reactive oxygen species (ROS) nitric oxide (NO). Sildenafil, a selective phosphodiesterase-5 (PDE5) inhibitor used for erectile dysfunction, exerts its cardiovascular effects enhancing NO. The aim this study was to investigate influence sildenafil on function atherosclerosis progression apolipoprotein E knockout (apoE −/− ) mice....
It has been previously shown that the probiotic kefir (a symbiotic matrix containing acid bacteria and yeasts) attenuated hypertension endothelial dysfunction in spontaneously hypertensive rats (SHR). In present study, effect of chronic administration on cardiac autonomic control heart rate (HR) baroreflex sensitivity (BRS) SHR was evaluated. Methods: were treated with (0.3 mL/100 g BW) for 60 days compared non-treated normotensive Wistar-Kyoto rats. Cardiac vagal (VT) sympathetic (ST) tones...
Sildenafil ameliorates aortic relaxations in apolipoprotein E knockout (apoE) mice. Now, we tested the hypothesis that endothelial dysfunction (ED) this model is characterized by contractile hyperresponsiveness to phenylephrine (PE) and abnormality may be repaired using sildenafil. The rings were evaluated apoE mice treated with sildenafil (apoE-sil, 40 mg/kg/day) compared wild-type (WT) administered vehicle (veh). apoE-veh exhibited an imbalance of nitric oxide reactive oxygen species...
The antimutagenic effect of botryosphaeran, an exocellular (1 → 3)(1 6)-β-d-glucan, from the ascomyceteous and plant-borne endophytic fungus, Botryosphaeria rhodina MAMB-05, was evaluated in young (6-8 weeks) elderly (18 months) Swiss albino mice both genders. hypolipidemic, hypoglycemic antiatherogenic potential also 18-month old male LDL receptor knockout (LDLr-/-) mice. Administration botryosphaeran by gavage (doses: 7.5, 15, 30 mg/kg b.w./day) a 30-day pretreatment protocol (young mice),...
The atherosclerotic apolipoprotein E-deficient (apoE-/-) mouse exhibits impaired vasodilation and enhanced vasoconstriction responsiveness. objectives of this study were: a) to determine the relative contribution cyclooxygenases (Cox-1 Cox-2), thromboxane A2 (TXA2) endothelin-1 (ET-1) enhancing vascular hyperresponsiveness in model atherosclerosis b) investigate beneficial effects phosphodiesterase 5 inhibitor sildenafil on endothelial dysfunction.Adult male apoE-/- mice were treated with...
By acting on multiple targets and promoting diverse actions, angiotensin II (Ang II) plays a pivotal role in vascular function. Recent studies suggested that phosphodiesterase-5 (PDE-5) inhibitors exhibit therapeutic effects cardiovascular diseases. Here, the of sildenafil disturbances were analyzed mouse model Ang II-induced hypertension.Male C57BL/6 mice used as untreated animals (control) or infused with (1000 ηg/kg/min) for 28 days treated (40 mg/kg/min) vehicle during last two weeks....
OxyElite Pro (OEP) is a dietary supplement to increase metabolism which contains as key stimulant the ingredient 1,3-dimethylamylamine (DMAA). Serious adverse effects have been reported after OEP consumption however, these are related poisoning or overdose. To our knowledge, no one studied of at controlled doses. Thus, aim this study was evaluate acute and chronic affects, doses in Wistar rats, on physical performance, metabolic parameters, liver injury markers oxidative stress mitochondrial...
Recently, we have reported cardiovascular protective effects of the probiotic kefir in a model primary hypertension. Now, evaluated beneficial secondary hypertension under hyperactivation renin-angiotensin-system by partially clipping one kidney artery (2K1C) for 60 days and compared with Sham rats. Maximum levels arterial pressure were reached 7–14 post-clipping both 2K1C 2K1C-Kefir, but after that time values approximately 20% lower 2K1C-Kefir Also, attenuated angiotensin converting enzyme...
In the present study, we evaluated effects of probiotic kefir on cardiovascular function in spontaneously hypertensive rats (SHR). SHR were chronically administered with oral 0.3 mL/100 g b.w. (SHR‐k) or vehicle (SHR‐v) for 60 days and compared Wistar (WR). comparison NWR, SHR‐v exhibited higher mean arterial pressure, which was significantly attenuated SHR‐k (108±2, 194±5 142±8 mmHg, respectively, p<0.01). Similarly observed angiotensin converting enzyme activity (91±7, 119±9 78±6%, The...
Vascular reactivity experiments using isolated aortic rings have been widely used as a model for physiological and pharmacological studies since the early sixties. Here, we suggest several parameters that researcher should pay attention to when investigating angiotensin II in their experimental models. Angiotensin is one of active peptides renin-angiotensin system exerts its effect through AT1 AT2 receptors. Some seek understand effects receptors at vascular level by experiments. However,...
The lab has previously shown that follistatin (FST), a glycoprotein inhibitor of activins, reduced blood pressure in the Spontaneously Hypertensive Rat (SHR) model Essential Hypertension. Short-term exposure (30 minutes) to FST also vessel contraction induced by potassium (KCl). This study aims illustrate mechanisms through which inhibits potassium-induced SHR and normotensive (WKY) rats. Function or WKY resistance mesenteric arteries was tested response KCl ion channel modulators using wire...
Follistatin lowers BP and improves resistance artery health in spontaneously hypertensive rats (SHR), a model of essential HTN. Functionally, follistatin smooth muscle contraction endothelium-dependent relaxation. Structurally, increased medial collagen was inhibited. Vascular ROS were also reduced. Perivascular adipose tissue (PVAT) regulates vascular tone via release vasoactive substances. Oxidative stress PVAT, as HTN, induces contractile agents. Transition from white to brown PVAT is...
Abstract Mercury is considered a risk factor for hypertension development and other cardiovascular diseases. Objectives: We investigated whether the effects of mercury exposure on hemodynamic parameters young Wistar prehypertensive SHR animals might influence time course development. Main methods: Young (4 weeks) male rats were randomly assigned to 4 groups: untreated (Wistar Ct), exposed chloride Hg); (SHR Ct) Hg) 30 days. Non-invasive invasive arterial pressure measured investigate...
Introduction: We previously showed that follistatin (FST), a potent activin inhibitor, lowers BP in the spontaneously hypertensive rat (SHR), model of essential HTN. This was associated with improved vessel structure (reduced collagen) and function hypercontractility endothelium-dependent relaxation). FST also reduced vascular oxidative stress (ROS). Perivascular adipose tissue (PVAT) is known to regulate tone. induces browning thus increased thermogenic activity peripheral tissue....