A5058509475- Spondyloarthritis Studies and Treatments
- Cancer-related molecular mechanisms research
- Rheumatoid Arthritis Research and Therapies
- Cancer Genomics and Diagnostics
- Molecular Biology Techniques and Applications
- Hip disorders and treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Autophagy in Disease and Therapy
- Single-cell and spatial transcriptomics
- Cancer, Lipids, and Metabolism
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Ferroptosis and cancer prognosis
- DNA Repair Mechanisms
- Systemic Lupus Erythematosus Research
- MicroRNA in disease regulation
- PARP inhibition in cancer therapy
- Cancer, Hypoxia, and Metabolism
- Statistical Methods in Clinical Trials
- Sirtuins and Resveratrol in Medicine
- Effects of Radiation Exposure
- Cancer Mechanisms and Therapy
- Cannabis and Cannabinoid Research
- Hemophilia Treatment and Research
- Inflammatory Myopathies and Dermatomyositis
- Pharmaceutical industry and healthcare
Texas Children's Hospital
2021-2023
Baylor College of Medicine
2019-2023
Texas A&M University
2018-2023
Children's Cancer Center
2019-2021
Roswell Park Comprehensive Cancer Center
2019
Center for Theoretical Biological Physics
2019
Rice University
2019
The University of Texas MD Anderson Cancer Center
2019
Breast Center
2019
Royal National Hospital for Rheumatic Diseases
1987-1991
Abstract Background RNA profiling technologies at single-cell resolutions, including and single-nuclei sequencing (scRNA-seq snRNA-seq, scnRNA-seq for short), can help characterize the composition of tissues reveal cells that influence key functions in both healthy disease tissues. However, use these is operationally challenging because high costs stringent sample-collection requirements. Computational deconvolution methods infer bulk-profiled samples using scnRNA-seq-characterized cell...
One hundred and one consecutive patients with ankylosing spondylitis (males 85%) were reviewed by radiographic evaluation after a mean disease duration of 21.2 years (mean age at onset 22.9 years). Osteitis pubis occurred in seven cases varied severity disease. Hip involvement (grade 2-4) 19%. Their (19.6 years) was younger than for those normal hips (25.1 years; p = 0.003). Lone sacroiliitis 3 4) without ascending spinal 11 patients. The lone marked similar (23.3 24.9 respectively; NS). By...
The molecular clock plays key roles in daily physiological functions, development and cancer. Period 2 (PER2) is a repressive element, which inhibits transcription activated by positive elements, resulting diurnal cycling of genes. However, there are gaps our understanding the role normal outside its time-keeping function. Here, we show that PER2 has noncircadian function crucial to mammalian mammary gland development. Virgin Per2-deficient mice, Per2−/−, have underdeveloped glands,...
e13173 Background: Inflammatory Breast Cancer (IBC) is a rare and highly aggressive form of advanced breast cancer. IBC largely subjective, clinical diagnosis that challenging to identify due unique skin changes swelling, often resembling infection. Additionally, general lack awareness about in the patient communities contributes delays treatment. Together, these issues hinder research advancements, leaving patients with limited treatment options poor prognoses. Methods: To address...
STUDY OBJECTIVE--The aim was to assess patients willingness accept mortal risk in the drug treatment of chronic rheumatic disease. DESIGN--A non-random sample consecutive were interviewed with a standardised survey instrument. SETTING--The study took place Royal National Hospital for Rheumatic Diseases, Bath, UK. PATIENTS--100 in- and out-patients aged 65 or less interviewed, 50 rheumatoid arthritis ankylosing spondylitis. Mean age 48 years mean disease duration 14 years. The group mainly...
Mitochondria operate as a central hub for many metabolic processes by sensing and responding to the cellular environment. Developmental cues from environment have been implicated in selective autophagy, or mitophagy, of mitochondria during cell differentiation tissue development. Mitophagy occurring this context, termed programmed responds state rather than mitochondrial damage is often accompanied transition. However, little known about mechanisms that engage execute mitophagy under...
Abstract The functionally differentiated mammary gland adapts to extreme levels of stress from increased demand for energy by activating specific protective mechanisms support neonatal health. Here, we identify the breast tumor suppressor gene, single-minded 2 s (SIM2s) as a novel regulator mitophagy, key component this response. Using tissue-specific mouse models, found that loss Sim2 reduced lactation performance, whereas gain (overexpression) Sim2s enhanced and extended performance...
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor prognosis and chemotherapy gemcitabine has limited effects associated development of drug resistance. Treatment Panc1 MiaPaca2 pancreatic cells induced expression the orphan nuclear receptor 4A2 (NURR1) analysis The Cancer Genome Atlas indicated NURR1 overexpressed in tumors negative prognostic factor for patient survival. Results knockdown or treatment antagonist 1,1-bis(3΄-indolyl)-1-(p-chlorophenyl)methane...
A woman with selective IgA deficiency and severe ankylosing spondylitis (AS), complicated by intractable peripheral arthritis, is described. Three previous cases of AS have been reported, all whom had AS. It suggested that a poor prognostic factor in therefore warrants further investigation to determine the clinical course such patients.
Abstract Background Mutations in genes associated with homologous recombination (HR) increase an individual’s risk of developing triple-negative breast cancer (TNBC). Although known for their role repairing dsDNA breaks, HR repair elements also stabilize and restart stalled replication forks. Essential to these functions are RAD51 its paralogs, each which has a unique preventing fork collapse restart. However, progress toward understanding the regulation factors been slow. With such pivotal...
Hepatoblastoma (HB) is the most common pediatric primary liver malignancy, and survival for high-risk disease approaches 50%. Mouse models of HB fail to recapitulate hallmarks disease. The aim this work was generate murine that show features including multifocal tumors, vascular invasion, metastasis, circulating tumor cells (CTCs). HepT1 were injected into livers or tail veins mice, growth monitored with magnetic resonance bioluminescent imaging. Blood analyzed fluorescence-activated cell...
ABSTRACT Most malignant hepatocellular tumors in children are classified as either hepatoblastoma (HB) or carcinoma (HCC), but some demonstrate features of both HB and HCC 1–3 . These have been recognized under a provisional diagnostic category by the World Health Organization distinguished from combination histological, immunohistochemical, molecular 4–6 Their outcomes cellular composition remain an open question 7–9 The heterogeneous histological profiles hepatoblastomas with (HBCs) 4 may...
Click to increase image sizeClick decrease size Additional informationNotes on contributorsJ. ElswoodJoyce Laing works in the Department of Child and Family Psychiatry, Playfield House, Cupar, Fife, is a Consultant Art Therapist Psychiatric Hospitals Prisons Chairwoman Scottish Society Psychology.