A5027098661- Cancer Genomics and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related Molecular Pathways
- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genomics and Phylogenetic Studies
- Colorectal Cancer Screening and Detection
- Genomic variations and chromosomal abnormalities
- Cancer-related gene regulation
- Genetic factors in colorectal cancer
- Phytochemicals and Medicinal Plants
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Mitochondrial Function and Pathology
- Gallbladder and Bile Duct Disorders
- Trace Elements in Health
- Circular RNAs in diseases
- Cancer Cells and Metastasis
- Synthesis and bioactivity of alkaloids
- Redox biology and oxidative stress
- Moringa oleifera research and applications
- Hedgehog Signaling Pathway Studies
- Bioactive Compounds and Antitumor Agents
First Affiliated Hospital of Zhengzhou University
2025
Henan Provincial Center for Disease Control and Prevention
2025
Children's Cancer Center
2015-2022
Baylor College of Medicine
1996-2022
Texas Children's Hospital
2015-2021
First Affiliated Hospital of Xinjiang Medical University
2021
Xinjiang Medical University
2021
University of North Carolina at Chapel Hill
2008-2020
Broad Institute
2018
Emory University
2018
We analysed primary breast cancers by genomic DNA copy number arrays, methylation, exome sequencing, messenger RNA microRNA sequencing and reverse-phase protein arrays. Our ability to integrate information across platforms provided key insights into previously defined gene expression subtypes demonstrated the existence of four main cancer classes when combining data from five platforms, each which shows significant molecular heterogeneity. Somatic mutations in only three genes (TP53, PIK3CA...
The Cancer Genome Atlas profiled 279 head and neck squamous cell carcinomas (HNSCCs) to provide a comprehensive landscape of somatic genomic alterations. Here we show that human-papillomavirus-associated tumours are dominated by helical domain mutations the oncogene PIK3CA, novel alterations involving loss TRAF3, amplification cycle gene E2F1. Smoking-related HNSCCs demonstrate near universal loss-of-function TP53 CDKN2A inactivation with frequent copy number including 3q26/28 11q13/22. A...
In our previous studies, we have shown that benzyl isothiocyanate (BITC) inhibits the growth of human pancreatic cancer cells by inducing apoptosis. present study, demonstrate activation all three (MAPK) family members [extracellular signal-regulated protein kinase (ERK), c-jun N-terminal (JNK) and P38] in response to BITC treatment. Exposure Capan-2 with varying concentrations for 24 h resulted phosphorylation (activation) ERK at Thr202/Tyr204, JNK Thr183/Tyr185 P38 Thr180/Tyr182, leading...
Objective To examine patient characteristics and outcomes in children with undifferentiated embryonal sarcoma of the liver (UESL) using a multi-institutional database. Summary Background Data UESL is rare disease (incidence one per million). Therefore, current literature mostly limited to small case series. Methods The National Cancer Database was queried for primary diagnosed between 1998 2012. Results A total 103 patients (<18 years) were identified. 5-year overall survival entire group...
Abstract Background Triphala is commonly used in Ayurvedic medicine to treat variety of diseases; however its mechanism action remains unexplored. This study elucidates the molecular against human pancreatic cancer cellular and vivo model. Methods Growth-inhibitory effects were evaluated Capan-2, BxPC-3 HPDE-6 cells by Sulphoradamine-B assay. Apoptosis was determined cell death assay western blotting. administered orally nude mice implanted with Capan-2 xenograft. Tumors analyzed...
Although abnormal activation of the sonic hedgehog (Shh) signaling pathway has been demonstrated in human hepatocellular carcinoma (HCC) patients and most HCC cell lines, mechanism by which Shh promotes development remains uncertain. Using a liver cancer model induced diethylnitrosamine (DEN) mimics process from injury, hepatocyte proliferation, hepatocirrhosis to canceration, we investigated examining expression Shh, patched-1 (Ptch), smoothened (SMO), glioma-associated oncogene-1 (Gli1)...
Traditional serrated adenoma (TSA) consists of glands with tall cells and short cells. Two kinds alternate to give a unique configuration. The aim this study was identify the relationship between alterations both Wnt pathways morphology TSAs. in 28 TSAs were separated by microdissection. Semi-nested polymerase chain reaction performed detect mutations BRAF, β-catenin, APC, KRAS. BRAF observed 22 (78.6%) TSAs, all occurred at In conclusion, mutation is associated Genetic pathway signaling may...
Hepatoblastoma (HB) is the most common pediatric primary liver malignancy, and survival for high-risk disease approaches 50%. Mouse models of HB fail to recapitulate hallmarks disease. The aim this work was generate murine that show features including multifocal tumors, vascular invasion, metastasis, circulating tumor cells (CTCs). HepT1 were injected into livers or tail veins mice, growth monitored with magnetic resonance bioluminescent imaging. Blood analyzed fluorescence-activated cell...
A 4-year-old girl diagnosed with stage III hepatoblastoma presented for tumor resection. She had received four neoadjuvant cycles of cisplatin, 5-fluorouracil, and doxorubicin good response. On perioperative imaging, several ring-enhancing lesions were noted in the liver concerning satellite vs. infectious etiology. biopsy revealed abscess due to Escherichia coli, so patient was admitted receive intravenous antibiotics. Ten days after admission, decreased size a right hemihepatectomy...
Abstract Objective The aim of the study was to investigate whether ethanolic extract propolis inhibits growth and induces apoptosis HL-60 cells. Methods cells were treated for 24, 48, 72 h with various concentrations extracts (0, 50, 100, 200 μg/mL). proliferation determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Subsequently, Hochest 33258 staining terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) used test We observed expression...
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Gastric hyperplastic polyps (GHPs) are the most common polypoid lesion of stomach, and their malignant potential has been demonstrated. In present study, we evaluated mucin phenotypes GHPs investigated relationships among clinical-pathological factors, proliferative activity p53 expression in GHPs.The CD10, MUC2, MUC5AC MUC6 patterns 238 were examined by immunohistochemical staining. The GHP divided into 4 subtypes: gastric phenotype (G-type), intestinal (I-type), mixed or gastrointestinal...
Abstract Purpose: Unresectable or metastatic hepatoblastoma generally confers a poor survival. MDM4 and MDM2 are the major negative regulators of p53, which has predominantly wild type status in hepatoblastoma. Having previously shown that copy gain/amplification associated with 1q32.1 amplicon hepatoblastoma, we hypothesize is predominant regulator p53 function blocking will cause tumor cell death due to uninhibited suppressor activity. Methods: An MTT assay was used measure NSC207895 (MDM4...
Abstract Radiation therapy continues to play a central role in the management of brain tumors. The radioresistance high-grade gliomas remains one reasons for failure treatment, which would otherwise require tumoricidal doses beyond normal tissue tolerance and safe clinical practice. Thus, determining cellular, molecular biochemical mechanisms underlying radiation resistance becomes critical successful treatment these For this purpose, glioma cell line U87 were treated with fractionated...