A5014629637- Child Nutrition and Water Access
- Obesity, Physical Activity, Diet
- Sepsis Diagnosis and Treatment
- Vitamin D Research Studies
- Neonatal Health and Biochemistry
- Child Nutrition and Feeding Issues
- Neuroblastoma Research and Treatments
- Lipoproteins and Cardiovascular Health
- Iron Metabolism and Disorders
- Genomics and Rare Diseases
- Childhood Cancer Survivors' Quality of Life
- Clostridium difficile and Clostridium perfringens research
- Gastrointestinal disorders and treatments
- Receptor Mechanisms and Signaling
- Testicular diseases and treatments
- Ultrasound in Clinical Applications
- Congenital heart defects research
- Nutritional Studies and Diet
- Nuclear Structure and Function
- Parathyroid Disorders and Treatments
- Cell death mechanisms and regulation
- Eating Disorders and Behaviors
- Sexual Differentiation and Disorders
- Cardiac electrophysiology and arrhythmias
- Cell Adhesion Molecules Research
Alexandria University
2017-2025
Pediatrics and Genetics
2019
Abstract The purpose of this study is to evaluate the demographics, clinical presentation, laboratory findings, and gastrointestinal endoscopic findings in children with CD assess their relationship interleukin-15 (IL-15) single-nucleotide polymorphism (SNP) (rs2857261) serum IL-15 levels. This case–control prospective cohort included 54 newly diagnosed pediatric patients attending Gastroenterology Clinic at Alexandria University Children’s Hospital 44 age- sex-matched healthy controls....
To evaluate the effect of bovine colostrum (BC) on treatment children with acute diarrhea attending outpatient clinic.This double-blind randomized controlled trial was conducted 160 diarrhea; 80 cases were randomly treated BC group and received placebo (placebo group). All investigated for bacterial causes (Salmonella spp, Shigella diarrheagenic E. coli (DEC), Campylobacter spp., Vibrio cholerae) as well Rotavirus antigen in stool.After 48 h, had a significantly lower frequency vomiting,...
Abstract Background Familial hypercholesterolemia (MIM: PS143890) is a genetic disorder characterized by an increase in blood cholesterol. LDLR one of the genes which their defect contributes to disorder. Affected individuals may carry heterozygous variant or homozygous/compound variants and those with biallelic pathogenic present more severe symptoms. Method We report Egyptian family familial hypercholesterolemia. Both proband parents have while sibling unaffected. Exome sequencing was...
Abstract Background Congenital generalized lipodystrophy (CGL) is a rare inherited disease characterized by near-total absence of adipose tissue and associated with organ system abnormalities severe metabolic complications. Here, we have analyzed the characteristics largest CGL cohort from Middle East North Africa (MENA) who not received lipodystrophy-specific treatment. Methods was diagnosed clinically treating physicians through physical assessment supported genetic analysis, fat loss...
The HDR syndrome is a rare autosomal dominant disorder characterised by Hypoparathyroidism, Deafness, and Renal dysplasia, caused inactivating heterozygous germline mutations in the GATA3 gene. We report an 11-year-old girl with mutation located at splice acceptor site of exon 5 gene (NM_001002295.2: c.925-1G>T). Functional studies using minigene assay showed that this abolished normal splicing pre-mRNA led to use cryptic site, resulting loss first seven nucleotides (TCTGCAG) mRNA. These...
Background: Low bone mineral density (BMD) is a characteristic feature of Beta thalassemia major (βTM) patients. Vitamin D important for mineralization. receptors (VDR) genetic variants may be related to vitamin status and BMD.Objectives: To evaluate the effect VDR on levels BMD in βTM Egyptian patients supplemented with D.Methods: This study was conducted forty children unrelated healthy sex age-matched controls. Serum calcium, phosphorus, ALP, ferritin were measured. (BsmI, TaqI, FokI)...
The cornerstone of emergency management sepsis is early, goal-directed therapy. purpose this study was to evaluate the effect intraosseous (IO) vs. intravenous (IV) access for resuscitation patients with septic shock admitted pediatric intensive care unit. This prospective interventional randomized clinical trial conducted on 60 who need rapid administration fluids and drugs; 30 cases were randomly chosen IO vascular access, while other selected IV access. route successfully secured in all a...
Abstract Aim To compare the accuracy of three different screening tools, namely, Paediatric Yorkhill Malnutrition Score (PYMS), Screening Tool for Assessment in Paediatrics (STAMP), and Risk on Nutritional Status Growth (STRONGKIDS), assessing malnutrition risk hospitalised children. Methods A cross‐sectional study was conducted 300 children aged 6 months to 15 years at Alexandria University Children's Hospital, Egypt. The sensitivity specificity each tool were calculated detect acute...
Understanding children's feeding practices and eating behaviors is important to determine etiology of childhood obesity. This study aimed explore the relationship between early practices, behavior body composition among primary school children.The data were collected from 403 children. They administered structured questionnaire, including sociodemographic characteristics, Child's Eating Behavior Questionnaire. Anthropometric blood pressure (BP) measurements performed.Children with obesity...
Objective: As schools have continuous and intensive contact during the first two decades of a child’s life, school-based interventions can instil healthy lifestyle behaviors. This study evaluated pilot Qatar’s nutrition education campaign. Methods: Qatar Obesity Reduction Study (QORS) was an observational examining campaign’s impact on children’s eating habits (self-reported questionnaire), physical activity levels (accelerometry), body composition (bioimpedance) across time periods...
During critical illness, children my experience various changes in their thyroid hormone levels. Such are termed non-thyroidal illness syndrome (NTI). The extent of change correlates with the severity and its outcomes critically ill patients. This study aimed to investigate correlation between shock derangement. prospective observational included forty patients aged one month five years who were admitted pediatric intensive care unit (PICU) shock. Thyroid function tests conducted on...
Chronic colitis is a major problem worldwide with high morbidity. Causes of chronic are heterogeneous. A cut-off level faecal calprotectin to predict inflammatory bowel disease (IBD) as cause lacking.To study the in different causes and measure differentiate between IBD non-IBD colitides.This prospective was conducted from June 2018 May 2019. The included all patients aged 2 months up 18 years who were confirmed have endoscopically histopathologically attending Gastroenterology Clinic at...
Abstract Fluid resuscitation is the initial therapy for septic shock worldwide. Prediction of fluid responsiveness essential optimizing administration. Only few pediatric studies have evaluated role inferior vena cava (IVC) as a reliable predictor responsiveness. The aim this study was to evaluate IVC parameters predictors in children (under age 5 years) having at different times from admission. A prospective observational included 51 shock. It conducted nine-bedded intensive care unit...
Background Sex assignment is a major issue in disorders of sexual differentiation (DSD). Not all conditions DSD have clear recommendations on and timing surgery. Reports about sex practice the influence culture religion Arab region are scarce. Methods A survey questionnaire was distributed to participants paediatric endocrinology conference. Four cases were presented. Participants asked fill their answers choice, reasons for particular assignment, strength own recommendation surgery based...
Immune thrombocytopenia (ITP) is characterized by dysregulated cellular immunity. Interleukin 17 (IL-17) and its secreting cells (Th17) are involved in the pathogenesis of ITP. Retinoic acid receptor–related orphan receptor γt (RORγt) chief regulator Th17 development. The interaction among Runt-related transcription factor 1 (RUNX1) IL-17-related genes ITP remains questionable. study aimed to evaluate expression RUNX1 RORγt together with IL-17A IL-17F childhood investigate their contribution...
Abstract Background In steroid-resistant nephrotic syndrome (SRNS), protracted proteinuria leads to the loss of thyroxine-binding proteins resulting in low thyroid hormones and damage renal tubules exhausts reserve. This study aimed assess function those patients with SRNS steroid-sensitive (SSNS). A comparative cross-sectional evaluated status 50 children an equal age- sex-matched SSNS, controls were enrolled this study. Demographic data, clinical examination, profile, tests conducted for...
Cyclin D2 (CCND2) is a crucial player in cell cycle regulation. CCND2 polymorphisms contribute to cancer predisposition.To evaluate the association of rs3217927 single nucleotide (SNP) and its expression levels with acute lymphoblastic leukemia (ALL) susceptibility Egyptian children potential prognostic role.The 5' nuclease allelic discrimination assay was used frequency SNP 80 newly diagnosed ALL age- sex-matched controls. relative were determined by real-time quantitative polymerase chain...
Although inborn errors of metabolism (IEM) are rare individually, collectively IEM cause substantial morbidity and mortality the diagnosis is challenging.To analyse epidemiological clinical data, final outcomes patients with a suspected (small molecule disorders type) admitted to paediatric intensive care unit (PICU).We collected analysed medical records data all PICU at Alexandria University Children's Hospital, from January 2010 December 2014, or confirmed small disorders, including...
Gaucher disease (GD) is the most common lysosomal storage disorder, aim of current study was to investigate hyperimmunoglobulinemia and abnormalities serum immunoglobulin G (IgG) subclasses in children with GD relation those findings phenotype genotype, duration enzyme replacement therapy (ERT), infection frequency. The included 20 Egyptian receiving ERT age-matched sex-matched healthy as controls. Serum Ig IgG subclass levels were measured GD. control subjects. Hyperimmunoglobulinemia...