A5103147158- Neuroinflammation and Neurodegeneration Mechanisms
- Barrier Structure and Function Studies
- Axon Guidance and Neuronal Signaling
- Angiogenesis and VEGF in Cancer
- Caveolin-1 and cellular processes
- Extracellular vesicles in disease
- Regulation of Appetite and Obesity
- Synthesis of Organic Compounds
- Diet and metabolism studies
- Cancer-related molecular mechanisms research
- Intracerebral and Subarachnoid Hemorrhage Research
- Bioactive Compounds in Plants
- Bacterial Genetics and Biotechnology
- Phytochemical compounds biological activities
- Salmonella and Campylobacter epidemiology
- Dietary Effects on Health
- Escherichia coli research studies
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Bioactive Compounds and Antitumor Agents
- Cell Adhesion Molecules Research
- Ferroptosis and cancer prognosis
- Neurological Disease Mechanisms and Treatments
China Medical University
2001-2024
First Affiliated Hospital of Bengbu Medical College
2016-2017
Ministry of Education of the People's Republic of China
2014
Tamkang University
2013
Paeonol is a major phenolic compound of the Chinese herb, Cortex Moutan, and known for its antioxidant, anti-inflammatory antitumor properties. The present study was designed to investigate therapeutic potential underlying mechanisms paeonol on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid (MPTP/p)-induced mouse model Parkinson's disease (PD). MPTP (25 mg/kg), followed by probenecid (250 administered via i.p. injection five consecutive days induce PD. (20 mg/kg) administrated...
Microvascular complications are the major outcome of type 2 diabetes progression, and underlying mechanism remains to be determined.
The ibeA gene (ibe10) previously identified by TnphoA mutagenesis is part of a 50-kDa full-length open-reading frame (ORF) encoded 1.37-kb DNA fragment. An isogenic in-frame deletion mutant (ZD1) was constructed chromosomal replacement with suicide plasmid pCVD442 carrying 2.1-kb fragment an deletion. Similar to the described insertion ZD1 significantly less invasive in human brain microvascular endothelial cells (BMECs) than parent strain. fully complemented ORF. subcloned into pET28a(+)...
ABSTRACT Neurological disorders are associated with an increase in the permeability of human brain microvascular endothelial cells (HBMEC). Our previous findings have indicated that EphA2 could HBMEC. Recent evidence has linked and vascular growth factor (VEGF) to abnormalities response. However, it is unclear whether involved VEGF‐induced changes Here, were determined by measuring transendothelial electrical resistance (TEER) flux FITC‐dextran. We found knockdown HBMEC abolished reduction...
Microvascular basement membrane (BM) plays a pivotal role in the interactions of astrocyte with endothelium to maintain blood-brain barrier (BBB) homeostasis; however, significance and precise regulation endothelial cell-derived BM component BBB remain incompletely understood. Here, we report that conditional knockout Atg7 cells (Atg7-ECKO) leads astrocyte-microvascular disassociation brain. Our results reveal astrocytic endfeet detachment from microvessels leakage Atg7-ECKO mice....
ABSTRACT The association of microglia with brain vasculature during development and the reduced vascular complexity in microglia‐deficient mice suggest role cerebrovascular angiogenesis. However, underlying molecular mechanism remains unclear. Here, using an vitro angiogenesis model, we found culture supernatant BV2 microglial cells significantly enhanced capillary‐like tube formation migration microvascular endothelial (BMECs). expression angiogenic factors, ephrin‐A3 ephrin‐A4, were...
DL‑3‑n‑butylphthalide (NBP) is extracted from rapeseed and exhibits multiple neuroprotective effects, exerted by inhibiting the inflammatory process, including reducing oxidative stress, improving mitochondrial function neuronal apoptosis. The present study aimed to investigate effects of NBP in a lipopolysaccharide (LPS)‑induced mouse model Parkinson's disease (PD). behavior mice was assessed using rotarod test open‑field test, amount tyrosine hydroxylase substantia nigra pars compacta...
Cerebral angiogenesis is a key event during brain development and recovery from injury. We previously demonstrated that Atg7 knockout impaired in the mouse brain. However, role of not completely understood. In this study, we used human microvascular endothelial cells (HBMECs) to investigate mechanism Atg7-regulated cerebral angiogenesis. found depletion specifically diminished expression β3 γ2 chains laminin-5, major component extracellular matrix. contrast, autophagy inhibitors did affect...
Cocaine abuse has been strongly linked to blood-brain barrier (BBB) dysfunction, though the exact mechanism by which cocaine disrupts BBB remains unclear. In this study, we found that treatment reduces expression of glucose transporter 1 (GLUT1) in brain microvascular endothelial cells, a key factor cocaine-induced uptake, leakage, and cognitive impairment. Mechanistically, our results show upregulates miR-320a, turn suppresses GLUT1 via beta 2-adrenergic receptor (ADRB2). Notably,...
The present study a series of (E)‐5‐methoxy‐2‐styryl‐4 H ‐pyran‐4‐ones 6a , 6b 6c 6d 6e 6f 6g 6h 6i 6j was synthesized and evaluated for growth inhibitory inhibition against carcinoma cells. eight cell lines examined demonstrated that SKHep cells exhibit significant structure‐activity relationship in response to the tested compounds. Among them, showed most potent activity SKHep, A549, AGS, H460 with GI 50 values 0.17, 8.3, 3.6, 8.0 μM, respectively.