A5101745825- Neuroscience and Neuropharmacology Research
- Pharmacological Receptor Mechanisms and Effects
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Axial and Atropisomeric Chirality Synthesis
- Ginseng Biological Effects and Applications
- Asymmetric Hydrogenation and Catalysis
- Cannabis and Cannabinoid Research
- Chemical Synthesis and Analysis
- Oral microbiology and periodontitis research
- Molecular spectroscopy and chirality
- Chemical synthesis and alkaloids
- Treatment of Major Depression
- Computational Drug Discovery Methods
- Asymmetric Synthesis and Catalysis
- Alkaloids: synthesis and pharmacology
- Pharmacological Effects of Natural Compounds
- Chemical Synthesis and Reactions
- Synthesis and Catalytic Reactions
- Virus-based gene therapy research
- Lipid metabolism and disorders
- Cholinesterase and Neurodegenerative Diseases
- Catalytic C–H Functionalization Methods
- Organoboron and organosilicon chemistry
- Plant tissue culture and regeneration
University of Chinese Academy of Sciences
2019-2025
Shanghai Institute of Materia Medica
2016-2025
Mianyang Institute of Traditional Chinese Medicine
2024
Shanghai Institute of Organic Chemistry
2016-2024
Chinese Academy of Sciences
2014-2024
Wuhan University of Science and Technology
2024
Northwest A&F University
2018-2024
University of Georgia
2024
Jilin Agricultural University
2015-2023
Southern University of Science and Technology
2020-2021
The axially chiral tetra-ortho-substituted biaryl skeleton exists in numerous biologically important natural products, pharmaceutical molecules, catalysts, and ligands. efficient synthesis of structures remains a challenging but unsolved problem. Among various asymmetric synthetic protocols, enantioselective Suzuki-Miyaura cross-coupling represents one the most straightforward versatile approaches. Herein we describe powerful coupling enabled by P-chiral monophosphorus ligand BaryPhos,...
Palladium-catalyzed enantioselective dearomative cyclization has enabled the concise and total syntheses of (−)-crinine (−)-aspidospermidine, as well a formal synthesis (−)-minfiensine.
Ginsenoside Re (Re) is one of the major components Panax ginseng Meyer. Rk3 (Rk3) a secondary metabolite Re. The aim this study was to investigate and compare effects underlying mechanisms on cyclophosphamide-induced myelosuppression.The mice myelosuppression model established by intraperitoneal (i.p.) injection cyclophosphamide. Peripheral blood cells, bone marrow nucleated colony yield hematopoietic progenitor cells in vitro were counted. levels erythropoietin, thrombopoietin, granulocyte...
Axially chiral biaryl motifs possessing ortho-heteroatom-substituted functionalities exist widely in the structures of natural products and have served as foundation for constructing prominent organocatalysts, ligands, functional materials, even bioactive molecules. However, a general enantioselective synthesis such with high synthetic value is rare. Taking advantage BaryPhos-facilitated asymmetric Suzuki-Miyaura cross-coupling, we established general, efficient construction ortho sulfur- or...
Insulin resistance (IR) plays a significant role in the development of obstructive sleep apnea (OSA). The metabolic score for insulin (METS-IR) is novel method assessing IR. This study aims to explore relationship between METS-IR and risk OSA. cross-sectional included total 8297 subjects from NHANES (National Health Nutrition Examination Survey) database, as well 581 patients who underwent monitoring Renmin Hospital Wuhan University. Logistic regression, subgroup analysis, receiver operating...
The significance of halogen bonding in protein-ligand interactions has been recognized recently. We present here the first comprehensive thermodynamic and structural characterization PDE5-inhibitor interactions. ITC studies reveal that binding strength between chlorine, bromine, iodine inhibitor protein is -1.57, -3.09, -5.59 kJ/mol, respectively. halogens interact with designed residue Y612 an unexpected buried water molecule.
Phosphodiesterase type 5 (PDE5) inhibitors are first-line therapy for pulmonary arterial hypertension (PAH) and erectile dysfunction. As a continuing work to improve the terminal half-lives oral bioavailabilities of our previously reported 4(3H)-pyrimidones, pharmacokinetics-driven optimization focusing on substituent is described. Two major congeneric series aminosulfonylphenylpyrimidones acylaminophenylpyrimidones, were designed, synthesized, pharmacologically assessed in vitro vivo. Among...
A protecting-group-free enantioselective tandem allylic substitution of o-phenylenediamines and o-aminophenols is realized for the first time with a Pd-WingPhos catalyst, providing expedient access to series chiral vinyl-substituted heterocycles in excellent ee yields under mild reaction conditions. The protocol applied successfully synthesis cholesteryl ester transfer protein (CETP) inhibitor.
An enantioselective palladium-catalyzed C–H arylation of functionalized pyrazoles/triazoles/imidazoles is developed, affording a variety axially chiral ortho-nitro/formyl-substituted heterobiaryls with excellent enantioselectivities and good yields. The method features deuterated P-chiral phosphorus ligand CD3-AntPhos, broad substrate scope heterobiaryls, mild reaction conditions, low palladium loadings.