A5046176019- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Genomics, phytochemicals, and oxidative stress
- Animal Nutrition and Physiology
- Biological and pharmacological studies of plants
- Tryptophan and brain disorders
- Genetic and phenotypic traits in livestock
- Natural product bioactivities and synthesis
- Plant-derived Lignans Synthesis and Bioactivity
- Wnt/β-catenin signaling in development and cancer
- Hormonal Regulation and Hypertension
- Bioactive Compounds and Antitumor Agents
- Plant-based Medicinal Research
- Animal Genetics and Reproduction
- Blood Pressure and Hypertension Studies
- Drug-Induced Hepatotoxicity and Protection
- Livestock and Poultry Management
- Reproductive Biology and Fertility
- Antioxidants, Aging, Portulaca oleracea
- Phytochemistry and Biological Activities
- Diet, Metabolism, and Disease
- Stress Responses and Cortisol
- Seaweed-derived Bioactive Compounds
- Kruppel-like factors research
- Food Quality and Safety Studies
Jilin Agricultural University
2016-2025
Beijing Luhe Hospital Affiliated to Capital Medical University
2025
Northwest University
2025
Jinzhou Medical University
2018-2024
Henan University
2024
Capital Medical University
2024
Shanghai Jiao Tong University
2024
XinHua Hospital
2024
Nanjing Medical University
2019-2022
Jiangsu Province Hospital
2019-2022
Aging and aging-related metabolic complications are global problems that seriously threaten public health. Taxifolin (TAX) is a novel health food has been widely proved to have variety of biological activities used in medicine. However, the delayed effect TAX on aging process not investigated. The purpose this study explore role as natural active substance brain tissue induced by D-galactose (D-Gal) determine supplementing metabolism intestinal flora bodies. model was established...
Aging is an inevitable and complicated process involving many physiological changes. Screening of natural biologically active anti-aging substances a current research hotspot. Phlorizin (PZ), important dihydrochalcone phytoconstituent, has been demonstrated to have antioxidant anti-tumor effects. In this paper, different doses PZ (20 40 mg/kg) were used the protective effect on D-galactose (D-gal)-induced aging mice. Following hematoxylin eosin staining by observing hippocampus, we found...
Drug resistance presents a formidable challenge in the realm of breast cancer therapy. Accumulating evidence suggests that enhancer zeste homolog 2 (EZH2), component polycomb repressive complex (PRC2), may serve as key regulator controlling drug resistance. EZH2 overexpression has been observed and many other malignancies, showing strong correlation with poor outcomes. This review aims to summarize mechanisms by which regulates resistance, specific focus on cancer, order provide...
The current study aimed to assess the effectiveness of pharmacological intervention with Platycodin D (PD), a critically active compound isolated from roots
Panaxynol (PAL, also called falcarinol) is widely found in plants of the Umbelliferae family, among which carrots are rich PAL, so it proved to be edible. PAL has neuroprotective effects and other pharmacological activities. This study aimed explore mechanisms action on chronic unpredictable mild stress (CUMS)-induced anxiety depression mice. The behavioral activities mice were first assessed by a CUMS-induced model. secretion levels monoamine neurotransmitters hypothalamic-pituitary-adrenal...
<h3>Background</h3> Persistent fibroblast activation initiated by transforming growth factor β (TGF-β) is a fundamental event in the pathogenesis of systemic sclerosis, and its pharmacological inhibition represents potential therapeutic strategy. The nuclear receptor, peroxisome proliferator-activated receptor γ (PPAR-γ), exerts potent fibrotic activity. synthetic oleanane triterpenoid, 2-cyano-3,12-dioxo-olean-1,9-dien-28-oic acid (CDDO), PPAR-γ agonist with effects on TGF-β signalling...
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by memory decline and cognitive impairments. The clinical treatments for AD have numerous adverse effects, hence the exploration of natural products therapy significant importance. Protocatechuic acid (PA), phenolic acid, has been shown to possess various pharmacological activities, including anti‐inflammatory, antioxidant, antitumor effects. However, mechanisms underlying its therapeutic potential remain...
Background Heart failure with preserved ejection fraction (HFpEF) is characterized by normal and diastolic dysfunction. The role of plasma homocysteine (Hcy) levels in HFpEF has been understudied, though elevated are known to affect cardiovascular health. Methods This retrospective observational study analyzed 80 patients matched controls without HFpEF. Fasting Hcy were measured using a dual-antibody sandwich enzyme-linked immunosorbent assay (ELISA). Standard echocardiographic evaluations...
Journal Article Cardiovascular Characteristics in American Youth With Prehypertension: Get access Haidong Zhu, Zhu 1Georgia Prevention Institute, Department of Pediatrics, Medical College Georgia, Augusta, Georgia. Search for other works by this author on: Oxford Academic PubMed Google Scholar Weili Yan, Yan Dongliang Ge, Ge Frank A. Treiber, Treiber Gregory Harshfield, Harshfield Gaston Kapuku, Kapuku Harold Snieder, Snieder Yanbin Dong Address correspondence and reprint requests to Dr....
In this work, we investigated the ameliorative effects of platycodin D (PD), a major active chemical ingredient isolated from roots Platycodon grandiflorum (PG), on high-fat diet (HFD)/streptozotocin (STZ)-induced type 2 diabetes (T2D) mice. PD treatment (2.5 and 5.0 mg kg-1) improved HFD-induced body weight gain. administration also decreased fasting blood glucose (FBG) level insulin tolerance levels. These data collectively showed that could maintain homeostasis. addition, diabetic mice...
Schisandra chinensis is a traditional Chinese medicine that has been used for treating insomnia and neurasthenia centuries. Lignans, which are considered to be the bioactive components, apt extracted by supercritical carbon dioxide. This study was conducted investigate sedative hypnotic activities of dioxide fluid extraction S. (SFES) in mice possible mechanisms. SFES exhibited an obvious effect on shortening locomotor activity dose-dependent (10–200 mg/kg) manner. (50 mg/kg, 100 200...
The Hippo/MST signaling pathway is a critical player in controlling cell proliferation, self-renewal, differentiation, and apoptosis of most tissues organs diverse species. Previous studies have shown that Salvador homolog 1 (SAV1), scaffolding protein which functions the system expressed mammalian ovaries play vital role governing follicle development. But exact biological effects chicken SAV1 prehierarchical development remain poorly understood. In present study, we demonstrated...