A5049827246- Synthesis and Biological Evaluation
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Fluorine in Organic Chemistry
- Synthesis and Reactions of Organic Compounds
- Synthesis and biological activity
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Ionic liquids properties and applications
- RNA and protein synthesis mechanisms
- Chemical Reactions and Mechanisms
- Radical Photochemical Reactions
- Heat shock proteins research
- Toxic Organic Pollutants Impact
- Synthesis and Reactivity of Heterocycles
- Effects and risks of endocrine disrupting chemicals
- TiO2 Photocatalysis and Solar Cells
- Synthesis and Characterization of Heterocyclic Compounds
- Advanced biosensing and bioanalysis techniques
- Analytical Chemistry and Sensors
- Synthesis and properties of polymers
- Luminescence and Fluorescent Materials
- Computational Drug Discovery Methods
- Per- and polyfluoroalkyl substances research
- Advanced Photocatalysis Techniques
- Porphyrin and Phthalocyanine Chemistry
University of Palermo
2016-2025
Istituto per le Tecnologie Didattiche
2020
University of Palermo
2016-2019
Istituto Euro Mediterraneo di Scienza e Tecnologia
2011-2018
Chiesi (France)
2016
Institute of Molecular Science and Technologies
2016
Bentham Science Publishers (United Arab Emirates)
2013
Bentham Science Publishers (China)
2013
Instituto di Biofisica
2012
Universität Hamburg
2009
The synthesis, the chemical and photochemical reactivity, use of 1,2,4-oxadiazoles in materials as bioactive compounds have been reviewed. material this survey includes some historical background, general features, state-of-the-art applications together with a critical discussion about current limitations suggestions for future developments.
Abstract This Review aims to provide early stage researchers with an updated guide applications of photochemically produced singlet oxygen and, at the same time, widen experienced researcher's perspectives in a holistic approach chemistry. Without being exhaustive, literature between 2010 and 2018 has been surveyed by focusing on critical evaluation new knowledge applications. After introductory section concerning production, detection, interactions biological systems, subsequent sections...
The presence in the mRNA of premature stop codons (PTCs) results protein truncation responsible for several inherited (genetic) diseases. A well-known example these diseases is cystic fibrosis (CF), where approximately 10% (worldwide) patients have nonsense mutations CF transmembrane regulator (CFTR) gene. PTC124 (3-(5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl)-benzoic acid), also known as Ataluren, a small molecule that has been suggested to allow PTC readthrough even though its target yet be...
Abstract The pathological aggregation and accumulation of tau, a microtubule-associated protein, is common feature amongst more than 18 different neurodegenerative diseases that are collectively known as tauopathies. Recently, it has been demonstrated the soluble hydrophobic tau oligomers highly toxic in vitro due to their capacity towards seeding misfolding, thereby propagating pathology seen across diseases. Modulating state through use small molecules could be useful therapeutic strategy...
Abstract This study investigates the distribution and conservation status of plant species in lentic wetlands Mediterranean islands. Field data on vascular macrophytes were collected from online national databases “Conservation island Basin” (MedIsWet). A comprehensive inventory was conducted, information main anthropogenic impacts priorities compiled. In addition to all hygro- hydrophytes, we retained those typically adapted environments with intermittent or temporary wetness. significant...
Phthalic acid esters (PAEs) are a class of ubiquitous and dangerous lipophilic chemicals widely used as additives in various products to improve their physical chemical properties. Although they have been banned many countries, persistence all environmental compartments is particular concern. The aquatic environment especially affected by these compounds because it strongly influenced both contamination anthropic origin natural contaminants including those produced biosynthetically some...
The structures of halogen-bonded infinite chains involving two diiodoperfluoroalkanes and a bent bis(pyrid-4′-yl)oxadiazole show that the geometry pyridyl pendant rings is translated into angle between formed halogen bonds.
The pathological aggregation of tau plays an important role in Alzheimer's disease and many other related neurodegenerative diseases, collectively referred to as tauopathies. Recent evidence has demonstrated that oligomers, small soluble prefibrillar aggregates, are highly toxic due their strong ability seed misfolding propagate the pathology seen across different diseases. We previously showed novel curcumin derivatives affect preformed oligomer pathways by promoting formation more...
The hydrazinolysis reaction of 5-perfluoroalkyl-1,2,4-oxadiazoles has been investigated. Nucleophilic addition the reagent to C(5)−N(4) double bond oxadiazole ring, followed by ring-opening and then ring-closure involving β-nitrogen atom hydrazino moiety C(3) explains formation 5-perfluoroalkyl-1,2,4-triazoles as final products. Useful applications in synthesis this uncommon can be claimed.
The reaction of 3-benzoyl-5-perfluoroalkyl-1,2,4-oxadiazoles with hydrazine has been investigated, evidencing the possibility competitive paths. Nucleophilic addition to electrophilic C(5) 1,2,4-oxadiazole ring, followed by ring opening and closure enlargement, leads high yield in very mild experimental conditions formation Z-oximes 3-perfluoroalkyl-6-phenyl-2H-1,2,4-triazin-5-ones (11a-c) as major products reaction. In turn, can attack carbonyl carbon giving...