A5040200169- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Inorganic Fluorides and Related Compounds
- Ionic liquids properties and applications
- Pneumocystis jirovecii pneumonia detection and treatment
- Crystal structures of chemical compounds
- Fluorine in Organic Chemistry
- Agricultural and Food Sciences
- Antifungal resistance and susceptibility
- Biological Activity of Diterpenoids and Biflavonoids
- Supramolecular Chemistry and Complexes
- Cyclopropane Reaction Mechanisms
- Electrostatic Discharge in Electronics
- Synthesis and biological activity
- Analytical Methods in Pharmaceuticals
- Synthesis and properties of polymers
- Ion-surface interactions and analysis
- Energetic Materials and Combustion
- Chemical Thermodynamics and Molecular Structure
- Natural product bioactivities and synthesis
- Phytochemical compounds biological activities
- Carbohydrate Chemistry and Synthesis
- Advanced Glycation End Products research
- Catalytic Cross-Coupling Reactions
Universidade de São Paulo
2017-2023
Pharmaceutical cocrystals have emerged over the past several decades as an alternative path for synthesizing stable and/or improved crystalline forms of active pharmaceutical ingredients. In this contribution, we developed a reproducible cocrystallization supramolecular synthesis four new cocrystal fluconazole (FLZ), antifungal multifunctional drug: fluconazole–fumaric acid monohydrate (1:1:1), fluconazole–malic (1:1), fluconazole–dipicolinic and fluconazole–adipic (1:1). All were...
Mechanochemistry synthesis was applied to the supramolecular and green scale-up production of a 1:1 drug–drug cocrystal involving antimetabolite prodrug 5-Fluorocytosine (5-FC) tuberculostatic drug Isoniazid (INH), namely, 5FC-INH. Crystalline material, also obtained by traditional slow evaporation methods, analyzed single-crystal X-ray diffraction (XRD). The crystal packing is stabilized classical N–H···N hydrogen-bond interaction between amine moiety 5-FC INH pyridine nitrogen. IR Raman...
Indolizines fused with a seven-membered ring were identified as promising anticancer scaffolds and had their cytotoxicity increased up to twenty times by late-stage functionalization.
Fluconazole (FLZ) is one of the most used antifungal drugs worldwide and has been focus various investigations with aim enhancing its biomedical application.
Reacting paroxetine HCl with oxalic, maleic, fumaric and <sc>l</sc>-tartaric acids results in the formation of novel molecular salts.
Supramolecular reaction of <bold>5-FC</bold> with caffeine, <italic>p</italic>-aminobenzoic and caprylic acid gave rise to solid forms physically stable in humid environments.
In this manuscript we introduce a broad solid-state characterization of 5-fluorocytosine (5-FC) solid forms obtained with picric (PA) and 3,5-dinitrosalicylic (DNSA) nitro acids.
This work describes the new facility for applied nuclear physics at University of Sao Paulo, mainly irradiation electronic devices. It is a setup composed quadrupole doublet beam focusing/defocusing plus multiple scattering through gold foils to produce low intensity, large-area, and high-uniformity heavy-ion beams from 1H 107Ag. Beam intensities can be easily adjusted 102 particles cm2/s hundreds nA an area as large 2.0 cm2 uniformity better than 90%. Its chamber has high-precision...
BACE1 is the secretase that acts in Aβ production Alzheimer's disease (AD).We investigated mRNA expression total blood and levels of plasma protein AD patients compared with cognitively healthy subjects. Probable (n = 47) non-AD control group 32) were evaluated for using reverse transcription-qPCR. A subsample n 21 20 had analyzed, ELISA.No differences found on between groups. However, higher detected patients.Blood-based diagnostic tools are desired to improve diagnosis. could provide an...