A5052873116- Pregnancy and preeclampsia studies
- MicroRNA in disease regulation
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Reproductive System and Pregnancy
- Chronic Myeloid Leukemia Treatments
- Viral-associated cancers and disorders
- Cardiac Structural Anomalies and Repair
- Energy and Environment Impacts
- Prenatal Screening and Diagnostics
- Extracellular vesicles in disease
- Garlic and Onion Studies
- Gene Regulatory Network Analysis
- Heme Oxygenase-1 and Carbon Monoxide
- COVID-19 Impact on Reproduction
- Protein Degradation and Inhibitors
- Prenatal Substance Exposure Effects
- Cardiac Arrest and Resuscitation
- RNA modifications and cancer
- Gestational Trophoblastic Disease Studies
- Cancer-related Molecular Pathways
- DNA and Nucleic Acid Chemistry
- Systemic Lupus Erythematosus Research
University of Toyama
2021-2025
Osaka University
2023
Tianjin Medical University
2023
Tianjin First Center Hospital
2023
Aging increases oxidative stress (OS) in the ovaries, leading to infertility-related dis-orders. Granulosa cells (GCs), which support folliculogenesis are chron-ically exposed excessive OS under pathological conditions. Here, we demonstrate significant role of Rubicon, an autophagy suppressor, as a DNA damage mediator GCs OS. Hydrogen peroxide (H2O2) decreased cell viability human GC line, HGrC1, due damage, without affecting autophagic activity. However, activation increased resistance...
Aging drives excessive ovarian oxidative stress (OS), impairing fertility and affecting granulosa cells (GCs), which are involved in folliculogenesis. This study aims to clarify the relationship between OS autophagy GCs identify compounds that enhance resistance. We identified Rubicon, an suppressor, as a key mediator of DNA damage under OS. Hydrogen peroxide (H2O2) compromised cell viability via human GC line, HGrC1, without autophagic activity. However, activation increased resistance...
Opportunities for the exposure of pregnant women to engineered nanoparticles have been increasing with expanding use these materials. Therefore, there are concerns that could adverse effects on establishment and maintenance pregnancy. The mother fetus evaluated from this perspective, but is still little knowledge about placentation function acquisition, which essential successful Formation syncytiotrophoblast indispensable acquisition placental function, impairment syncytialization...
Poor placentation is closely related with the etiology of preeclampsia and may impact fetal growth restriction. For placental developmental growth, we have demonstrated that dysregulation autophagy, a key mechanism to maintain cellular homeostasis, in trophoblasts contributes pathophysiology preeclampsia, severe pregnancy complication, associated poor placentation. It remains, however, unknown whether autophagy inhibition affects trophoblast syncytialization. This study evaluated effect an...
Abstract Autophagy is a bulk degradation system that maintains cellular homeostasis by producing energy and/or recycling excess proteins. During early placentation, extravillous trophoblasts invade the decidua and uterine myometrium, facing maternal immune cells, which participate in suppression of paternal fetal antigens. Regulatory T cells will likely increase response to specific antigen before during pregnancy. Insufficient expansion antigen‐specific Treg possess same cell receptor,...
RET kinase through homodimerization mediated by illegitimate disulfide bond formation in the extracellular domain.RET-CaLM mutants possessed oncogenic and tumorigenic activities that could be suppressed existing tyrosine inhibitors targeting RET.This study identifies calcium-binding ablating mutations as a novel type of mutation demonstrates silico-driven annotation VUSs druggable oncogenes is promising strategy to identify targetable driver for precision oncology.