Abstract Aims Metformin is the most widely used oral anti‐diabetes agent and has considerable benefits over other therapies, yet 20–30% of people develop gastrointestinal side effects, 5% are unable to tolerate metformin due severity these effects. The mechanism for effects their inter‐individual variability unclear. We have recently shown association between organic cation transporter 1 ( OCT 1) variants severe intolerance in with Type 2 diabetes. aim this study was explore reduced‐function...

The aim of study was to evaluate endocrine changes in PCOS women during metformin treatment. One hundred with PCOS, aged 20-40 years were included. A complete hormonal and metabolic pattern recorded for each subject every 6 months. Metformin treatment after 12 months significantly reduced weight, BMI, waist circumference, insulin HOMA-IR (p=0.000) high differences variances within repeated measurements. There significant reduction PRL, testosterone estradiol small did not have effect on TSH....

FTO, a gene recently discovered in genomewide associated studies for type 2 diabetes mellitus (T2D), play an important role the management of energy homeostasis, nucleic acid demethylation and regulation body fat mass by lipolysis. The aim this study was to analyze association FTO rs8050136 A>C genetic variant with clinical biochemical parameters T2D population West Balkan region (Bosnians Herzegovinians Kosovars).The included 638 patients prediabetes 360 healthy controls both genders, aged...

Stroke is the third leading cause of mortality, disability and dementia, but epileptic manifestations in elderly. Diabetes mellitus as permanently elevated blood glucose, often accompanied by dyslipidemia, among causes atherosclerotic alteration vessels also increasing world.To determine existence predilection diabetes development ischemic stroke.During 2011 are analyzed all people with stroke admitted at Neurology Clinic. All patients underwent neurological tests laboratory test special...

Our aim was to determine the incidence of prediabetes and risk developing cardiovascular disease (CVD) in women with polycystic ovary syndrome (PCOS). This prospective, observational study included 148 PCOS, without Type 2 diabetes mellitus (T2DM) CVD present at baseline. In fasting blood samples, we measured lipids, glucose, insulin levels during oral glucose tolerance test, C-reactive protein (CRP), steroids, 25-hydroxyvitamin D (25-OHD), prolactin, thyroid-stimulating hormone, parathyroid...

Polycystic ovary syndrome (PCOS) is a frequent endocrine disease in women during the reproductive period. It considered complex metabolic disorder with long-term metabolic, as well consequences. Main pathophysiological pathways are related to increased androgen levels and insulin resistance. Nowadays, genetic origins of PCOS acknowledged, numerous genes involved pathogenesis hyperandrogenemia, resistance, inflammation, disturbed folliculogenesis. Rotterdam diagnostic criteria most widely...

The response to metformin, the most commonly used drug for treatment of type 2 diabetes (T2D), is highly variable. common variant rs7903146 C>T within transcription factor 7-like gene (TCF7L2) strongest genetic risk associated with T2D date. In this study, we explored effects TCF7L2 genotype on metformin in T2D. study included 86 newly diagnosed patients T2D, incident users metformin. Levels fasting glucose, insulin, HbA1c, total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides,...

We aimed to determine whether the administration of statins type 2 diabetics without pre-existing CHD reduced incidence and their effects on cholesterol CRP levels. All participants were carefully interviewed, clinically examined, laboratory tested exclude conditions likely provoke an inflammatory response that was exclusion criterion. Exclusion criteria: Serious heart, liver or kidney problems, history renal transplant, recent drug alcohol abuse, HbA1c>10%, blood pressure >140/90mmHg,...

Women with Polycystic Ovary Syndrome (PCOS) are at increased risk for cardiovascular morbidity and metabolic disorders including: dyslipidaemia, hypertension, insulin resistance, gestational diabetes, type 2 systemic inflammation endothelial dysfunction. The prevalence of obesity resistance in women PCOS is significantly higher compared to the general population. Lipid accumulation product a new, cheap easily available predictor syndrome both population PCOS.The study included 50 patients...

Common variants in <i>MTNR1B</i>, encoding melatonin receptor 1B, have been recently associated with impaired glucose homeostasis and an increased risk for developing Type 2 diabetes (T2D). In this study we investigated the association of <i>MTNR1</i>B variant rs10830963 T2D related quantitative traits a population from Bosnia Herzegovina (BH). A total number 268 subjects were recruited (162 patients 106 nondiabetic controls). Subjects genotyped <i>MTNR1B</i> SNP by using hydrolysis probes....

Abstract Background Previous studies reported conflicting results regarding association of insulin receptor substrate 1 ( IRS1 ) gene variation with type 2 diabetes (T2D) and resistance (IR) in different ethnic groups. We examined the rs7578326, rs2943641, rs4675095 T2D related traits a population from Bosnia Herzegovina, which is one European countries highest prevalence 12.5%. Methods Our study included 390 patients 252 control subjects. Biochemical parameters, including fasting glucose...

Introduction: Diabetes mellitus(DM) is considered an independent cardiovascular risk factor.Having in mind concomitant occurence of diabetes and other factors, it expected that patients with poor glucoregulation will have more factors higher than good glucoregulation.Aim: To compare between poorly controlled well-controlled mellitus.Material Methods: Hundered ten aged 40-70 years suffering from mellitus type 2 were included.Research designed as a retrospective, descriptive study.Patients...

In approximately 50-70% of all women with PCOS (Polycystic Ovarian Syndrome) may be found lower or higher degree insulin resistance, while insensitivity to cells very likely contributes hyperandrogenaemia which is responsible for the symptoms and signs PCOS. Insulin prediabetes are linked.This research retrospective-prospective, clinical, comparative descriptive. The study included 60 PCOS, aged 20-40 years, no acute chronic diseases, divided into two groups: elevated body weight normal...

COVID-19 infection has shown many complications on all organ systems, including the pancreas, during acute phase of and in post covid period.Our goal was to compare frequency patients with type 1 2 diabetes Outpatient Clinic "Srce Sarajeva", year before COVID-19, 2019, infection, 2020 2021. Our second monitor incidence after time onset disease, treatment options for individual depending value glucose.The study designed as a retrospective-prospective, consent Director patient consent, period...

Elevated C-reactive protein (CRP) in association with hyperinsulinemia is a significant risk factor for cardiovascular diseases and that plays key role the development of PCOS. We evaluated serum CRP level, before after metformin therapy obese women polycystic ovarian syndrome (PCOS). Thirty five PCOS [BMI=28,2+/-1,84 kg/m2, aged 20-35 years] were studied. Patients received orally dose 850 mg per day. The patients carefully interviewed, clinically examined, laboratory tested to eliminate...

The accumulation of macrophages what happens in atherosclerotic process is associated with increased concentration fibrinogen and CRP (C-reactive protein), these two markers inflammation are considered early signs atherosclerosis.The aim the study was to compare levels inflammatory (CRP fibrinogen) HbAlc as a parameter quarterly blood glucose control patients both diabetes mellitus type 1 hypothyroidism who have ischemic heart disease same autoimmune diseases, but without disease.This...

Dipeptidyl peptidase-4 (DPP-4) inhibitors are a new class of antihyperglycemic drugs that block degradation ofincretin hormones.To assess the effects oftreatment with DPP-4 on glucoregulation and body weight in obese patients type 2 diabetes mellitus.The study included 9 females males (n=18), BMI=31.24 +/- 2,26 kg/m2, mean age 58 6,8 years. The have been thoroughly evaluated before treatment, 6 months after treatment inhibitor (sitagliptin) combination metformin.After metformin HbAlc...

The objective of this study was to investigate the efficacy octreotide therapy in acromegalic patients as primary or secondary therapy.Ten diagnosed at Endocrinology Clinic Sarajevo (seven females and three males, mean age 55.2 ± 7.2 years, range 40-65 five with microadenoma macroadenoma) were treated octreotide. Among them, 60% operated on majority procedures performed transnasaly (90%). That group had recidivism disease (pituitary adenoma acromegaly). concentration human growth hormone...

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)