A5066429160- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Diet and metabolism studies
- Pharmacogenetics and Drug Metabolism
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- Drug Transport and Resistance Mechanisms
- Pancreatic function and diabetes
- Metabolomics and Mass Spectrometry Studies
- Peroxisome Proliferator-Activated Receptors
- Lipid metabolism and biosynthesis
- Vanadium and Halogenation Chemistry
- Adipose Tissue and Metabolism
- Ethics and Legal Issues in Pediatric Healthcare
- Heme Oxygenase-1 and Carbon Monoxide
- Asthma and respiratory diseases
- BRCA gene mutations in cancer
- Ethics in medical practice
- Vitamin K Research Studies
- Allergic Rhinitis and Sensitization
- Adipokines, Inflammation, and Metabolic Diseases
- Ovarian function and disorders
- Lipid metabolism and disorders
Khalifa University of Science and Technology
2019-2024
Centre of Research Excellence in Nutrition and Metabolism
2020
University of Sarajevo
2010-2019
International University of Sarajevo
2013-2019
University of Massachusetts Chan Medical School
2003-2004
University of British Columbia
2002
Objective: Tobacco cigarette smoking is one of the major leading causes death throughout world.Smoking has both acute and chronic effect on haematological parameters.The aim present study was to assess extent adverse effects biochemical characteristics in healthy smokers.Subjects Method: One hundred fifty six subjects participated this study, 56 smokers 100 non-smokers.The were regularly consuming 10-20 cigarettes per day for at least 3 years.Complete blood cell count analyzed by CELL-DYN...
Abstract Aims Metformin is the most widely used oral anti‐diabetes agent and has considerable benefits over other therapies, yet 20–30% of people develop gastrointestinal side effects, 5% are unable to tolerate metformin due severity these effects. The mechanism for effects their inter‐individual variability unclear. We have recently shown association between organic cation transporter 1 ( OCT 1) variants severe intolerance in with Type 2 diabetes. aim this study was explore reduced‐function...
Mendelian randomization (MR) provides us the opportunity to investigate causal paths of metabolites in type 2 diabetes and glucose homeostasis. We developed tested an MR approach based on genetic risk scoring for plasma metabolite levels, utilizing a pathway-based sensitivity analysis control nonspecific effects. focused 124 circulating that correlate with fasting Erasmus Rucphen Family (ERF) study (n = 2,564) possible effect each vice versa. detected 14 potential effects by MR, following...
FTO, a gene recently discovered in genomewide associated studies for type 2 diabetes mellitus (T2D), play an important role the management of energy homeostasis, nucleic acid demethylation and regulation body fat mass by lipolysis. The aim this study was to analyze association FTO rs8050136 A>C genetic variant with clinical biochemical parameters T2D population West Balkan region (Bosnians Herzegovinians Kosovars).The included 638 patients prediabetes 360 healthy controls both genders, aged...
Recent studies have introduced serum uric acid (UA) as a potential risk factor for developing diabetes, hypertension, stroke, and cardiovascular diseases. The value of elevated levels UA in diabetes development is still under scrutiny. data suggest that clearance being reduced with increase insulin resistance marker prediabetes period. However, conflicting related to patients Type 2 prompted us study the urine/serum ratio (USRUA) these healthy controls. All subjects included were free...
Our aim was to determine the incidence of prediabetes and risk developing cardiovascular disease (CVD) in women with polycystic ovary syndrome (PCOS). This prospective, observational study included 148 PCOS, without Type 2 diabetes mellitus (T2DM) CVD present at baseline. In fasting blood samples, we measured lipids, glucose, insulin levels during oral glucose tolerance test, C-reactive protein (CRP), steroids, 25-hydroxyvitamin D (25-OHD), prolactin, thyroid-stimulating hormone, parathyroid...
Increasing evidence is demonstrating that a patient's unique genetic profile can be used to detect the disease's onset, prevent its progression, and optimize treatment. This led increased global efforts implement personalized medicine (PM) pharmacogenomics (PG) in clinical practice. Here we investigated perceptions of students from different universities Bosnia Herzegovina (BH) towards PG/PM as well related ethical, legal, social implications (ELSI). descriptive, cross-sectional study based...
<p><strong>Aim <br /></strong>To analyse the long-term impact of altered metabolism on level mediators inflammatory response in female patients with type 2 diabetes. /><strong>Methods /></strong>This study included 97 diabetes and 107 female, nondiabetic control subjects, who were recruited at Clinical Centre University Sarajevo General Hospital Tešanj. The effects glycaemic...
This is the first study performed in population from Bosnia & Herzegovina (BH), which we analysed a significance of genetic variations drug-metabolising enzyme, cytochrome P450 (CYP), pathogenesis Type 2 diabetes. We have determined allele frequencies for CYP2C9*2, CYP2C19*2, and CYP2D6*4 diabetic patients nondiabetic controls. Genomic DNA was extracted blood samples collected 37 44 subjects. A real-time polymerase chain reaction used detection specific CYP polymorphisms, with...