Previous studies have reported that S-arylation produces diaryl disulfide when the precursors include sulfur powder and aryl halide using CuI as catalyst. However, our research has revealed use of different bases in above process results coproduction diarylsulfane diaryldisulfane. In addition, we demonstrated ratio two products can be controlled by selecting alkalinity bases. 1H NMR spectra showed diaryldisulfane was first product, which became reagent a reaction with to form through...

In an attempt to study the role of Eps8 in human carcinogenesis, we observe that ectopic overexpression SW480 cells (low expression) increases cell proliferation. By contrast, expressing eps8 small interference RNA SW620 and WiDr (high reduces their proliferation rate. Interestingly, attenuation decreases Src Pi-Tyr-416, Shc Pi-Tyr-317, serum-induced FAK Pi-Tyr-397 Pi-Tyr-861. Remarkably, by virtue mammalian target rapamycin/STAT3 Pi-Ser-727, modulates expression required for Within 62%...

Toll-like receptors (TLRs) are crucial in macrophage phagocytosis, which is pivotal host innate immune response. However, the detailed mechanism not fully defined. Here, we demonstrated that induction of Src and Eps8 LPS-treated macrophages was TLR4- MyD88-dependent, their attenuation reduced LPS-promoted phagocytosis. Confocal microscopy indicated colocalization TLR4 cytosol at phagosome. Consistently, both were present same immunocomplex regardless LPS stimulation. Inhibition this complex...

The pedicle screw is one of the main tools used in spinal deformity correction surgery. Robotic and navigated surgeries are usually used, they provide superior accuracy placement than free-hand fluoroscopy-guided techniques. However, their high cost space limitation problematic. We a new solution using 3D printing technology to facilitate surgery.A workflow was developed assist surgery technology. trajectory profile screws were determined on image system by surgical team. engineering team...

Abstract The oncoprotein Eps8 facilitates proliferation in fibroblasts and colon cancer cells. However, its role human cervical is unclear. By immunohistochemical staining Western blotting, aberrant expression was observed carcinoma compared with normal epithelial Clinicopathologic analysis of 45 patients indicated that associated parametrium invasion lymph node metastasis, two major poor prognostic factors for early-stage cancer. Kaplan-Meier specimens also an inverse relationship between...

A series of Cu complexes bearing N-heterocyclic carbene were synthesized, and their application for the copper-catalyzed azide–alkyne cycloaddition reaction was studied. The catalytic results demonstrated that [L2Cu]Br exhibited most activity, trend other I > Br Cl ∼ BF4 PF6. 1H NMR spectrum LCuCl phenylacetylene NHC ligand dissociated from atom deprotonated to produce phenylacetylide. conductivity study also proved this phenomenon. According density functional theory calculations, a...

Columbianadin (CBN), a natural coumarin isolated from Angelica decursiva, is reported to have numerous biological activities, including anticancer and platelet aggregation inhibiting properties. Here, we investigated CBN’s anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 cell activation deciphered the signaling process, which could be targeted by CBN as part of mechanisms. Using mouse model LPS-induced acute liver inflammation, effects were examined distinct...

Abstract Breast cancer intrinsic subtypes have been identified based on the transcription of a predefined gene expression (GE) profiles and algorithm (prediction analysis microarray 50 set, PAM50). The present study compared molecular subtyping with oligonucleotide NanoString nCounter assay. A total 109 Taiwanese breast cancers (24 adjacent normal tissues) were assayed Affymetrix Human Genome U133 plus 2.0 microarrays 144 while 64 patients for both platforms. Subtyping nearest centroid...

We retrospectively reviewed surgical results of posterolateral transpedicular partial corpectomy without anterior vertebral reconstruction in 23 consecutive patients with symptomatic metastatic spinal cord compression at thoracic spine.To evaluate postoperative outcomes and survival rates undergoing reconstruction.The need for after radical resection body tumors has been emphasized by several authors. However, the stability spine is substantially increased rib cage. The role may be not...

Abstract Purpose Controversy exists regarding the extent to which lymph node dissection (LND) should be performed for operable colorectal cancers (CRCs) during primary surgical resection. We reappraised role of LND in CRCs. Methods Seventy-three CRC patients (mean age, 65.3 years; 43 males) undergoing resection at Taipei Hospital, Ministry Health and Welfare, Taiwan, within a 3-year period were retrospectively analyzed. Their pathological T/N/M statuses cancer stages defined according...

Several studies have reported that metal complexes exhibit anti-inflammatory activities; however, the molecular mechanism is not well understood. In this study, we used a potent ruthenium (II)-derived compound, [Ru(η6-cymene)2-(1H-benzoimidazol-2-yl)-quinoline Cl]BF4 (TQ-6), to investigate mechanisms underlying effects against lipopolysaccharide (LPS)-induced macrophage activation and liver injury in mice. Treating LPS-stimulated RAW 264.7 cells with TQ-6 suppressed nitric oxide (NO)...

Sub-total/total gastrectomy with lymph node dissection (LND) remains an effective therapeutic strategy for resectable gastric adenocarcinomas (GACs). Despite the prognostic significance of positive nodes (PLNs) defined in N-status, few have appraised impacts negative (NLNs) and percentage NLN (=number NLNs/number total [TLNs], %), as well extent TLNs to be dissected GACs.We retrospectively analyzed 62 GAC patients (mean age 67.1 years; 41 men) undergoing primary sub-total/total from a single...

Platelets play a major role in hemostatic events and are associated with various pathological events, such as arterial thrombosis atherosclerosis. Iridium (Ir) compounds potential alternatives to platinum compounds, since they exert promising anticancer effects without cellular toxicity. Our recent studies found that Ir show potent antiplatelet properties. In this study, we evaluated the vitro antiplatelet, vivo antithrombotic structure⁻activity relationship (SAR) of newly synthesized...

The monomeric title complex, [Zn(C14H12NOS)2]·2CHCl3 or L2Zn·2CHCl3, where L is the 2-({[2-(methyl-sulfan-yl)phen-yl]imino}-meth-yl)phenolate anion, may be obtained by reaction of LZnEt with benzyl alcohol two equivalents LH ZnEt2 in tetra-hydro-furan. Zn atom, located on a twofold axis, four-coordinated distorted tetra-hedral geometry O atoms [Zn-O = 1.9472 (19) Å] from phenolate anions and imine N [Zn-N 2.054 (2) Å].

Background and Objective: Platinum compounds are largely replaced by iridium (Ir)-based metal complexes as these display encouraging anticancer effects with less side effects.Iridium exhibited notable properties against platelet activation, however, its effect anti-neuroinflammatory remain unknown.Therefore, a comparative of novel (Ir-3, Ir-6 Ir-11) were investigated in LPS-induced BV2 microglial cells.Materials Methods: Quantitative real-time PCR was performed to detect the mRNA expression...