A5039565818- Aquaculture Nutrition and Growth
- Metabolomics and Mass Spectrometry Studies
- Protein Hydrolysis and Bioactive Peptides
- Aquaculture disease management and microbiota
- Cancer, Hypoxia, and Metabolism
- Enzyme Production and Characterization
- vaccines and immunoinformatics approaches
- Adipokines, Inflammation, and Metabolic Diseases
- ATP Synthase and ATPases Research
- Regulation of Appetite and Obesity
- Synthesis and Biological Evaluation
- Phytoestrogen effects and research
- Fish Biology and Ecology Studies
- Alzheimer's disease research and treatments
- Moringa oleifera research and applications
- Natural Antidiabetic Agents Studies
- Cholinesterase and Neurodegenerative Diseases
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Medicinal Plants and Neuroprotection
- Genetics, Bioinformatics, and Biomedical Research
- Effects of Radiation Exposure
- Phytochemicals and Antioxidant Activities
- Microbial Natural Products and Biosynthesis
- Machine Learning in Bioinformatics
Sri Dharmasthala Manjunatheshwara College of Dental Sciences & Hospital
2021-2025
Shri Dharmasthala Manjunatheshwara University
2021-2024
Karnataka Veterinary Animal and Fisheries Sciences University
2020-2023
In oxygen-deprived conditions, cells respond by activating adaptive mechanisms to bolster their survival and protect tissue integrity. A key player in this process is the HIF-1α signaling cascade, meticulously regulated Prolyl Hydroxylase Domain 2 (PHD2), which orchestrates cellular responses varying oxygen levels. The primary aim of investigation utilize gut siderophores as inhibitors PHD2 ischemic conditions. This study also helps understanding structural microbiota regulate via inhibition...
Alzheimer's disease (AD) is a type of neurodegenerative disease, associated with the hastening ROS, acetylcholinesterase (AChE) activity, and amyloid β peptides plaques in brain. The limitations side effects existing synthetic drugs incline toward natural sources. In present communication active principles methanolic extract Olea dioica Roxb, leaves are explored as an antioxidant, AChE inhibitor, anti-amyloidogenic. Furthermore, neuroprotection against beta-peptide has been studied....
Colorectal carcinoma (CRC) is one of the common carcinomas with a rising incidence metastasis due to its advanced stage presentation. The existing biomarkers such as CEA (Carcinoembryonic antigen) etc., for prognosis, have low sensitivity and specificity. Hence need newer definitive biomarker. Obesity leading cause CRC. Leptin adiponectin secreted by adipose tissue been studied potential in field present study helps understand association leptin receptors clinicopathological parameters.
Trypsin from viscera of Indian mackerel (Rastralliger kanagurta) was purified by ammonium sulphate precipitation and chromatographic techniques such as size exclusion, ion exchange, affinity chromatography, with a 14.4-fold increase in specific activity 18.7% recovery. The molecular weight the trypsin estimated to be approximately 26 kDa using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Purified showed amidase-specific which determined...
<title>Abstract</title> In oxygen-deprived conditions cells respond by activating adaptive mechanisms to bolster their survival and protect tissue integrity. A key player in this process is the HIF-1α signaling cascade, meticulously regulated Prolyl Hydroxylase Domain 2 (PHD2), which plays a central role orchestrating cellular responses fluctuating oxygen levels. The primary aim of investigation explore potential PHD2 inhibitors using in-silico methods employing molecular docking dynamic...
Background: The SARS-CoV2 was responsible for the pandemic situation across world. is an RNA virus, and its replication depends on Dependent Polymerase (RdRp). Hence, blocking of RdRP would be alternative strategy to inhibit virus multiplication without affecting host physiology. Objective: current study investigated inhibitory effect bioactive compound F3 isolated from P. citrinum CGJ-C2 in-silico derivates against RdRp COVID using computational methods. Methods: Compound derivatives were...
Analysis of SARS-CoV-2 spike protein sequences over 19 countries from biological databases submitted around the globe was carried out with help bioinformatics tools and structure prediction databases. Initial data analysis showed entry virus into different geographic regions started in month January 2020. Meanwhile, alignment isolates China other revealed a critical mutation D614G. Surprisingly, D614G not seen early samples but gradually it appearing globally March However, mutations amino...
Background: We previously synthesized two DNA intercalative Pyrimido[4’,5’:4,5]thieno(2,3-b) quinolines (PTQ), 9-hydroxy-4-(3-diethylaminopropylamino)pyrimido[4’,5’:4,5]thieno(2,3-b) (Hydroxy- DPTQ) and 8-methoxy-4-(3-diethylaminopropylamino) pyrimido[4’,5’:4,5]thieno(2,3-b) (Methoxy-DPTQ), reported their cytotoxicity against cancer cell lines. Methods: In the present study, we sought to analyze antitumor activity of Hydroxy-DPTQ Methoxy-DPTQ on Ehrlich’s ascites carcinoma in vivo models,...