A5085321360- Musculoskeletal pain and rehabilitation
- Pain Management and Placebo Effect
- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Health, Medicine and Society
- Dementia and Cognitive Impairment Research
- Botulinum Toxin and Related Neurological Disorders
- Anesthesia and Pain Management
- Pain Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Pain Management and Opioid Use
- Pediatric Pain Management Techniques
- Functional Brain Connectivity Studies
- Alzheimer's disease research and treatments
- Pain Management and Treatment
- Memory and Neural Mechanisms
- Mitochondrial Function and Pathology
- Pluripotent Stem Cells Research
- Healthcare Systems and Practices
- Neurological Disorders and Treatments
- Hereditary Neurological Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Emotions and Moral Behavior
- Parkinson's Disease Mechanisms and Treatments
Assistance Publique – Hôpitaux de Paris
2011-2024
Inserm
2010-2024
Université de Versailles Saint-Quentin-en-Yvelines
2013-2024
Université Paris-Saclay
2022-2024
Hôpital Ambroise-Paré
2008-2020
Laboratoire physiopathologie et pharmacologie clinique de la douleur
2020
Hôpital Raymond-Poincaré
2014
Hospices Civils de Lyon
2011-2012
CHU Ambroise Paré
2008
Université Paris-Est Créteil
2004
Previous research suggests that patients with Alzheimer's disease (AD) are impaired on executive function early in the course of disease, but negative findings were reported. To evaluate performance tasks AD and to determine involvement memory outcome tasks. Thirty-six divided into two subgroups basis MMSE: very mild mild. The comparison 17 normal controls shows had deficits visuospatial short-term memory, episodic flexibility self-monitoring abilities, concept formation reasoning. showed...
We assessed for the first time long-term maintenance of repetitive transcranial magnetic stimulation (rTMS)-induced analgesia in patients with chronic widespread pain due to fibromyalgia. Forty consecutive were randomly assigned, a double-blind fashion, 2 groups: one receiving active rTMS (n=20) and other, sham (n=20), applied left primary motor cortex. The protocol consisted 14 sessions: an "induction phase" 5 daily sessions followed by "maintenance 3 week apart, fortnight month apart....
Huntington's disease (HD) is a monogenic neurodegenerative that affects the efferent neurons of striatum. The protracted evolution pathology over 15 to 20 years, after clinical onset in adulthood, underscores potential therapeutic tools would aim at protecting striatal neurons. Proteins with neuroprotective effects adult brain have been identified, among them ciliary neurotrophic factor (CNTF), which protected animal models HD. Accordingly, we carried out phase I study evaluating safety...
We assessed cortical excitability and intracortical modulation systematically, by transcranial magnetic stimulation (TMS) of the motor cortex, in patients with fibromyalgia. In total 46 female fibromyalgia 21 normal subjects, matched for age, were included this study. TMS was applied to hand area both hemispheres evoked potentials (MEPs) recorded first interosseous muscle contralateral hand. Single-pulse used measurements rest threshold (RMT) suprathreshold MEP. Paired-pulse assess short...
To investigate whether patients diagnosed with amnestic mild cognitive impairment (MCI) have also in attention/executive functions, and therefore to clarify all subcomponents of executive control are equally affected MCI.MCI refers the transitional state between normal aging dementia. Amnestic MCI is characterized by impaired episodic memory, although subtle functions has been noted on neuropsychologic tests.We investigated 20 controls using language, praxis tests.MCI had significantly lower...
It is well established that chronic pain impairs cognition, particularly memory, attention and mental flexibility. Overlaps have been found between the brain regions involved in modulation including particular prefrontal cortex anterior cingulate cortex, which are executive function, memory. However, whether cognitive function may predict has not investigated. We addressed this question surgical patients, because such patients can be followed prospectively no before surgery. In prospective...
No study has directly compared the effectiveness of repetitive transcranial magnetic stimulation (rTMS) and direct-current (tDCS) in neuropathic pain (NP). In this 2-centre randomised double-blind sham-controlled study, we efficacy 10-Hz rTMS anodal 2-mA tDCS motor cortex sham contralateral to painful area (3 daily sessions) patients with NP due lumbosacral radiculopathy. Average intensity (primary outcome) was evaluated after each session 5 days later. Secondary outcomes included symptoms...
Huntington's disease (HD) is an autosomal dominant genetic with devastating clinical effects on cognitive, psychological, and motor functions. These symptoms primarily relate to the progressive loss of medium-spiny GABA-ergic neurons striatum. There no known treatment date. Several neurotrophic factors have, however, demonstrated capacity protect striatal in various experimental models HD. This includes ciliary factor (CNTF), substance examined this protocol. An ex vivo gene therapy approach...
Huntington's disease is a hereditary in which degeneration of neurons the striatum leads to motor and cognitive deficits. Foetal striatal allografts reverse these deficits phenotypic models developed primates. A recent open‐label pilot study has shown some clinical improvement or stabilization three out five patients who received bilateral grafts foetal neurons. We show here that changes were associated with reduction cortical hypometabolism, demonstrating able restore function...
The role of the basal ganglia, and more specifically striatum, in language is still debated. Recent studies have proposed that linguistic abilities involve two distinct types processes: retrieving stored information, implicating temporal lobe areas, application combinatorial rules, fronto-striatal circuits. Studies patients with focal lesions neurodegenerative diseases suggested a for striatum morphological rule application, but functional imaging found left caudate was involved syntactic...
Several studies have evaluated executive function in depressed patients, and the results vary from significant impairment relative to controls virtually intact performances. To better comprehend elderly patients with major unipolar depression, performance of 21 was compared that 19 normal on tasks. The relationships between memory deficits depression severity dysfunction were also examined. Depressed patients’ significantly worse than almost all Their score for logical correlated several...
To further clarify the cognitive syndrome in subcortical vascular dementia (VaD), we investigated 20 patients with early-stage VaD as compared 30 Alzheimer’s disease (AD) and 22 normal controls using episodic memory, attention/executive function language tests. The patient groups were closely matched terms of age, education severity dementia. had a significantly better free recall, cued recall recognition memory than AD patients, being within limits VaD. In addition, greater number...
To assess the natural progression of cognitive impairment in Huntington's disease (HD) and to reveal factors that may mask this progression.Although numerous cross-sectional studies reported deterioration at different stages disease, progressive has been, up now, difficult demonstrate neuropsychological longitudinal studies.The authors assessed 22 patients early HD yearly intervals for 2 4 years (average, 31.2 +/- 10 months), using a comprehensive battery based on Core Assessment Program...
To investigate the relationships between cognitive impairment and apathy in patients with early Huntington's disease (HD) to further explore influence of depression on outcome changes associated apathy.We included 36 HD patients, among them 20 were apathetic (HDA) 16 not (HDnA). The two groups matched by age, education severity disease. Cognitive functions evaluated a comprehensive neuropsychological battery that measures memory, attention, executive function, language visuospatial...
Abstract We aimed to investigate the genetic associations of neuropathic pain in a deeply phenotyped cohort. Participants with were cases and compared those exposed injury or disease but without as control subjects. Diabetic polyneuropathy was most common aetiology pain. A standardised quantitative sensory testing protocol used categorize participants based on profile. performed genome-wide association study, subset participants, we undertook whole-exome sequencing targeting analyses 45...
Abstract In recent studies aimed at assessing the effects of original therapeutic strategies applied to patients with Huntington's disease (HD), we observed informative changes in electrophysiological results that recovered normal values coherence clinical improvement. However, longitudinal were lacking for determining whether test evolve parallel markers natural course and could consequently provide objective quantifiable progression. For this purpose, testing was performed annually a...