A5043154280- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS Impact and Responses
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- Adolescent Sexual and Reproductive Health
- Global Maternal and Child Health
- Frailty in Older Adults
- Global Health Care Issues
- Health Systems, Economic Evaluations, Quality of Life
- Pneumocystis jirovecii pneumonia detection and treatment
- Insect-Plant Interactions and Control
- Health disparities and outcomes
- Poverty, Education, and Child Welfare
- Tuberculosis Research and Epidemiology
- Child Nutrition and Water Access
- Hepatitis B Virus Studies
- HIV, Drug Use, Sexual Risk
- Aging and Gerontology Research
- Cytomegalovirus and herpesvirus research
- Nutrition and Health in Aging
- Immunodeficiency and Autoimmune Disorders
- Geriatric Care and Nursing Homes
- Blood Pressure and Hypertension Studies
- Salmonella and Campylobacter epidemiology
Libera Università Maria SS. Assunta
2015-2024
Repubblica e Cantone Ticino
2018-2023
Presidio Ospedaliero
2009-2023
Community Living
2023
University of Rome Tor Vergata
1990-2020
Saint Camillus International University of Health and Medical Sciences
2020
Policlinico Umberto I
2020
Link Campus University
2015-2019
Istituto Superiore di Sanità
2004-2018
Azienda Sanitaria Locale Roma 3
2018
Background: The Drug Resource Enhancement against AIDS and Malnutrition (DREAM) program is a large antiretroviral therapy treatment financed by the Treatment Acceleration Program (TAP) of World Bank.In addition to provision individuals infected with human immunodeficiency virus (HIV) in sub-Saharan Africa, one major aspect DREAM nutritional supplementation prevention mother-to-child transmission (PMTCT) HIV.Methods: HIV-positive pregnant women enrolled receive highly active (HAART) free...
The brown marmorated stink bug, Halyomorpha halys (Stål), native to East Asia, emerged as an invasive pest in Europe the 2000s. In its range, Trissolcus japonicus (Ashmead) is dominant egg parasitoid of H. halys, and thus it has been considered for classical biological control countries invaded by pest. A survey parasitoids conducted 2017 2018 with frozen, sentinel masses revealed that T. was already present apple orchards Canton Ticino, Switzerland. recovered both years from three different...
The brown marmorated stink bug Halyomorpha halys is an invasive agricultural pest with a worldwide distribution. Classical biological control has been identified as the most promising method to reduce populations of H. halys. Adventive two candidates for releases, Trissolcus japonicus and mitsukurii, have recently detected in Europe. To assess their distribution abundance, large-scale survey was performed. From May September 2019, wide area covering northern Italy parts Switzerland surveyed,...
The response to treatment and risk factors for early mortality following initiation of combination antiretrovirals (ARVs) in a cohort African patients are described retrospective design. Medical history, laboratory parameters, data were reviewed initiating ARVs 12 clinical centers Mozambique, Tanzania, Malawi. Among 3456 HIV-1-infected who received more than 6 months, at baseline 72% had WHO stages 3/4, 7% viral load <400 copies/ml, 38% CD4 cell count >200/μl. One year later, 78%...
Antiretroviral treatment programs in sub-Saharan Africa have high rates of early mortality and loss to follow-up. Switching second-line regimens is often delayed because limited access laboratory monitoring.Retrospective analysis was performed a cohort adults who initiated standard first-line antiretroviral at 5 public sector sites 3 African countries. Monitoring included routine CD4 cell counts, human immunodeficiency virus RNA measures, records whether appointments were kept. Incidence...
Reduction of HIV-1 breast-feeding transmission remains a challenge for prevention pediatric infections in Sub-Saharan Africa. Provision formula decreases but often increases child mortality this setting.A prospective observational cohort study exposed infants mothers receiving pre and postnatal medical care at Drug Resource Enhancement Against AIDS Malnutrition centers Mozambique was conducted. Live-born HIV-1-infected women were enrolled. testing performed 1, 6, 12 months age using branched...
Objective: To evaluate pregnancy outcomes in a cohort of HIV-infected women receiving triple antiretroviral therapy (ART) for prevention mother-to-child-transmission. Methods: A retrospective study with review records 3273 HIV-positive prenatal care Malawi and Mozambique from July 2005 to December 2009 was conducted Drug Resource Enhancement Against AIDS Malnutrition (DREAM) centers. Patients were offered nevirapine-based ART initiated until 6 months postpartum. Main outcome measures...
Italy was one of the first European countries affected by new coronavirus (COVID-19) pandemic, with over 105,000 infected people and close to 13,000 deaths, until March 31st. The pandemic has hit especially hard because country's demographic structure, a high percentage older adults. authors explore possibility, recently aired in some studies, extensive intergenerational contact as possible determinant severity among Italian We analyzed several variables test this hypothesis, such patients...
Nevirapine is widely used to treat HIV-1 infection prevent mother-to-child transmission; unfortunately adverse drug reactions have been reported. Our aim was identify genes/variants involved in nevirapine-induced hepatotoxicity.Patients from Mozambique, 78 with hepatotoxicity and without events, were genotyped for ABCB1, CYP2B6, CYP3A4 CYP3A5 gene variants. We conducted a case-control association study genotype/phenotype correlation analysis.The ABCB1 c.3435C>T SNP associated (p = 0.038),...
BackgroundOptimized preventive strategies are needed to reach the objective of eliminating pediatric AIDS. This study aimed define determinants residual HIV transmission in context maternal antiretroviral therapy (ART) administration pregnant women, assess infant safety this strategy, and evaluate its impact on disease. Methodology/Principal FindingsA total 311 HIV-infected women were enrolled Malawi an observational received a nevirapine-based regimen from week 25 gestation until 6 months...
OPINION article Front. Med., 30 April 2018 | https://doi.org/10.3389/fmed.2018.00123
Abstract Serological studies in infants can provide valuable information on the degree of protection conferred by IgG maternal passive transfer during early life. If infant levels are inadequate, may be incomplete, increasing risk life-threatening diseases such as pertussis and measles, before immunization completion. In addition, HIV infection, -highly prevalent African countries like Malawi—may impair transplacental antibody transfer. We determined anti-Pertussis Toxin (PT) anti-measles 86...
Abstract The reduction of atmospheric sulphur dioxide pollution is causing increasing problems deficiency in sulphur‐demanding crop plants northern Europe. Elemental and many containing compounds such as cysteine‐rich antifungal proteins, glucosinolates (GSL) phytoalexins play important roles plant disease resistance. aim this work was to analyse the effect inadequate supply on resistance oilseed rape ( Brassica napus ). Compared with fertilized rape, healthy looking S‐deficient showed...
Objective To assess the incidence and consequences of adverse reactions among African HIV‐positive pregnant women treated with fixed‐dose combinations a nevirapine‐containing antiretroviral (ARV) triple therapy. Methods A retrospective analysis clinical files 703 HIV‐1‐positive regimen between May 2002 July 2004 was conducted. Selection criteria for inclusion in were: (a) taking ARV more than 14 days; (b) baseline values transaminases below threshold 2.5 times upper limit normal (ULN). The...
Tuberculosis is a major health concern in several countries, and effective diagnostic algorithms for use human immunodeficiency virus (HIV)-positive patients are urgently needed.At prescription of antiretroviral therapy, all 3 Mozambican centers were screened tuberculosis, with combined approach: World Health Organization (WHO) 4-symptom screening (fever, cough, night sweats, weight loss), rapid test detecting mycobacterial lipoarabinomannan urine (Determine TB LAM), molecular assay...
The generalist egg parasitoid Anastatus bifasciatus (Geoffroy) (Hymenoptera: Eupelmidae) is the most prevalent of invasive Halyomorpha halys (Stål) (Hemiptera: Pentatomidae) in Europe. To assess its efficacy against pest H. and to validate potential risks for non-target species a realistic field setting, inundative releases were conducted over three consecutive years four fruit orchards Switzerland Italy. In total, more than 4300 A. females released, which was equivalent 11,000 26,000 per...
HIV-infected patients have increased risk of noncommunicable diseases (NCDs). HIV+ in Africa are experiencing growing comorbidities due to increase life expectancy and long-time antiretroviral therapy (ART). HIV prevalence Malawi is one highest the world (10.8% women 6.4% men); few data available about NCDs epidemiology elderly Malawi. A retrospective analysis routine medical records 14 health centers run by Disease Relief through Excellent Advanced Means (DREAM) program was carried out. All...
Maintaining treatment adherence among the growing number of patients receiving antiretroviral in Africa is a dramatic challenge. The objective our study was to explore results computerized pill count method and test validity, sensitivity, specificity this with respect viral load measurement an African setting.We performed prospective, observational involving who received first-line highly active therapy Mozambique from 1 April 2005 through 31 March 2006. Enrolled had for at least 3 months...
Background HIV infection is a major contributor to maternal mortality in resource-limited settings. The Drug Resource Enhancement Against AIDS and Malnutrition Programme has been promoting HAART use during pregnancy postpartum for Prevention-of-mother-to-child-HIV transmission (PMTCT) irrespective of CD4 cell counts since 2002. Methods Records all HIV+ pregnancies followed Mozambique Malawi from 6/2002 6/2010 were reviewed. cohort was comprised by where women referred PMTCT started prenatal...
Limited information is available on antiretroviral concentrations in women/infant pairs receiving prophylaxis for breastfeeding transmission of HIV and the relationship between drug levels virological haematochemistry parameters.Patient population included HIV-positive pregnant women from gestational week 25 until 6 months after delivery their breastfed infants. Blood breast milk samples were collected at delivery, 1, 3 postpartum. Drug measured by liquid chromatography-mass...