A5076066327- Genetic factors in colorectal cancer
- Multiple and Secondary Primary Cancers
- Cancer Diagnosis and Treatment
- Dietary Effects on Health
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- BRCA gene mutations in cancer
- Cancer Risks and Factors
- Metabolomics and Mass Spectrometry Studies
- Clinical Nutrition and Gastroenterology
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Gestational Diabetes Research and Management
- Diet and metabolism studies
- Cancer, Lipids, and Metabolism
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Muscle metabolism and nutrition
- Nutritional Studies and Diet
- Agriculture and Farm Safety
- Air Quality and Health Impacts
- Obesity and Health Practices
- Hepatitis C virus research
National Cancer Institute
2024-2025
University of Maryland, Baltimore
2020-2025
National Institutes of Health
2025
Division of Cancer Epidemiology and Genetics
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Georgetown University
2018-2019
Georgetown University Medical Center
2018
Hepatocellular carcinoma (HCC) causes more than half a million annual deaths worldwide. Understanding the mechanisms contributing to HCC development is highly desirable for improved surveillance, diagnosis, and treatment. Liver tissue metabolomics has potential reflect physiological changes behind development. Also, it allows identification of biomarker candidates future evaluation in biofluids investigation racial disparities HCC. Tumor nontumor tissues from 40 patients were analyzed by...
Disparities in hepatocellular carcinoma (HCC) incidence and survival have been observed between ethnic groups including African-Americans (AA) European-Americans (EA). The evaluation of the changes levels metabolites samples stratified by race could provide a snapshot ethnically diverse disease related pathways identify reliable biomarkers. In this study, we considered AA EA to investigate that may be associated with HCC race-specific manner. 46 plasma samples, collected from patients...
Background The burden of diabetes and cardiovascular risk is not uniform across the USA, with much this disparity tracking differences in socioeconomic status, cultural practices lifestyle. To further evaluate disparities these disorders, we assessed prevalence diabetes, hypertension, hypercholesterolemia an Old Order Amish community that characterized by distinctive sociocultural include a very cohesive social structure limited use modern technologies medications. We compared conditions...
Abstract With advances in the early detection and treatment of cancer, incidence multiple primary cancers (MPC) or second has increased over time. Characterization etiologic risk factors, including family history within general population is critical for assessing MPC patients. We examined association between cancer among first-degree relatives a prospective study 139,958 participants from Prostate, Lung, Colorectal, Ovarian Cancer Screening Trial. Cox proportional hazard models were used to...
Although obesity is a known risk factor, the impact of weight change on colorectal adenoma less clear and could have important implications in disease prevention. We prospectively evaluated adulthood incident adenoma.We assessed during early-late (age 20 years to baseline, ie, ages 55-74 years), early-middle (20-50 middle-late (50 years-baseline) using self-reported data relation distal Prostate, Lung, Colorectal Ovarian Cancer Screening Trial (cases = 1053; controls 16 576). For each...
Abstract Objectives: Genetic susceptibility is thought to contribute the development of multiple primary cancers (MPC), often called secondary cancers. Although rare variants risk, these only account for a small fraction MPC cases. The contribution common risk unknown. Methods: To identify genetic associated with MPC, we conducted trans-ancestry meta-analysis genome-wide association studies (GWAS), including 7,360 cases and 138,684 controls from Prostate, Lung, Colorectal Ovarian (PLCO)...
<div>Abstract<p>With advances in the early detection and treatment of cancer, incidence multiple primary cancers (MPC) or second has increased over time. Characterization etiologic risk factors, including family history within general population is critical for assessing MPC patients. We examined association between cancer among first-degree relatives a prospective study 139,958 participants from Prostate, Lung, Colorectal, Ovarian Cancer Screening Trial. Cox proportional hazard...
<div>Abstract<p>With advances in the early detection and treatment of cancer, incidence multiple primary cancers (MPC) or second has increased over time. Characterization etiologic risk factors, including family history within general population is critical for assessing MPC patients. We examined association between cancer among first-degree relatives a prospective study 139,958 participants from Prostate, Lung, Colorectal, Ovarian Cancer Screening Trial. Cox proportional hazard...
Abstract Objective Postpregnancy weight retention contributes to obesity, but the long-term effect of parity on body mass index (BMI) and other cardiometabolic risk factors is unclear. We aimed evaluate relationship between BMI among highly parous Amish women, both before after menopause, associations with glucose, blood pressure, lipids. Methods conducted a cross-sectional study 3,141 women 18 years or older from Lancaster County, PA, who participated in our community-based Research Program...
Objective: Serrated adenoma is recognized as a precancerous lesion of colorectal cancer, and the serrated pathway considered an important that can independently develop into cancer. However, little known about related risk factors carcinogenesis adenoma. The purpose this study was to analyze distribution characteristics potential malignant in colon rectum. Methods: A retrospective case-control conducted collect clinical data patients with who underwent colonoscopy were pathologically...
Abstract Obesity is a known risk factor for colorectal cancer, but the influence of weight change during one's lifetime on adenoma, precursor to less understood. We prospectively investigated association between in different time periods adulthood and adenoma. included 1,041 incident distal adenoma cases (negative baseline trial flexible sigmoidoscopy screen positive follow-up 3-5 years later) 16,394 controls both screens) from screening arm Prostate, Lung, Colorectal Ovarian Cancer...