A5101635957- Protein purification and stability
- Receptor Mechanisms and Signaling
- Microbial Natural Products and Biosynthesis
- Photosynthetic Processes and Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Enzyme Production and Characterization
- Adenosine and Purinergic Signaling
- Plant biochemistry and biosynthesis
- Enzyme Catalysis and Immobilization
- Analytical Chemistry and Chromatography
- Peroxisome Proliferator-Activated Receptors
Huazhong Agricultural University
2024
Rockefeller University
2020
Tsinghua University
2010
The characterization of specific metabolite–protein interactions is important in chemical biology and drug discovery. For example, nuclear receptors (NRs) are a family ligand-activated transcription factors that regulate diverse physiological processes animals key targets for therapeutic development. However, the identification ligands many NRs remains challenging, because limitations domain-specific analysis ligand binding cells. To address these limitations, we developed covalent reporter...
Abstract Plant pathogens cause devastating diseases, leading to serious losses agriculture. Mechanistic understanding of pathogenesis plant lays the foundation for development fungicides disease control. Mitophagy, a specific form autophagy, is important fungal virulence. The role cardiolipin, mitochondrial signature phospholipid, in mitophagy and largely unknown pathogenic fungi. functions enzymes involved cardiolipin biosynthesis relevant inhibitors were assessed using set assays,...