A5102801521- Tryptophan and brain disorders
- Schizophrenia research and treatment
- Stress Responses and Cortisol
- Diet and metabolism studies
- Pain Mechanisms and Treatments
- Crop Yield and Soil Fertility
- Inflammasome and immune disorders
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Neuroinflammation and Neurodegeneration Mechanisms
- Nuclear Receptors and Signaling
- Receptor Mechanisms and Signaling
- Metabolism, Diabetes, and Cancer
- Neurological diseases and metabolism
- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- Circadian rhythm and melatonin
- Neuropeptides and Animal Physiology
- Photoreceptor and optogenetics research
- Prion Diseases and Protein Misfolding
- Folate and B Vitamins Research
- Pharmacological Receptor Mechanisms and Effects
- Diabetes Treatment and Management
- Pediatric Pain Management Techniques
- Retinal Development and Disorders
Shanghai Mental Health Center
2017-2025
Henan University of Science and Technology
2025
Shanghai Jiao Tong University
2017-2025
Center for Excellence in Brain Science and Intelligence Technology
2025
Chinese Academy of Sciences
2021-2025
Shanghai Institute of Materia Medica
2021-2023
China Pharmaceutical University
2021
Agency for Science, Technology and Research
2021
Singapore Bioimaging Consortium
2021
The tillage method and straw returning are the two most important agronomic measures for crop production, but their combined effects on nutrient accumulation utilization grain yield in dryland winter wheat (Triticum aestivum L., namely wheat)–summer maize (Zea mays maize) double-cropping system still poorly understood. present study delves into impact of wheat–maize based a field split-plot positioning experiment (started October 2009). Three methods—plowing (PT, 30–35 cm depth), rotary (RT,...
Atypical antipsychotics are highly effective antischizophrenic medications but their clinical utility is limited by adverse metabolic sequelae. We investigated whether upregulation of macrophage migration inhibitory factor (MIF) underlies the insulin resistance that develops during treatment with most commonly prescribed atypical antipsychotic, olanzapine. Olanzapine monotherapy increased BMI and circulating insulin, triglyceride, MIF concentrations in drug-naive schizophrenic patients...
A specific neural circuit for resolving the motivational conflict between feeding and acute pain.
Diabetic patients receiving the antidiabetic drug metformin have been observed to exhibit a lower prevalence of anxiety disorders, yet precise mechanism behind this phenomenon is unclear. In our study, we found that induces region-specific reduction in AMPK activity medial prefrontal cortex (mPFC). Concurrently, transgenic mice with brain-specific knockout displayed abnormal anxiety-like behaviors. Treatment or overexpression restored normal mPFC and mitigated social stress-induced...
Olanzapine (OLZ) is efficacious whereas leads to adverse metabolic effects thus lead higher risk of cardiovascular diseases (CVD) on schizophrenia. Cytokines have been found associated with disorders. Therefore, pretreatment prediction OLZ-induced urgently needed. To investigate if baseline cytokine levels could become biomarkers for pathogenesis schizophrenia or effects, we recruited 75 participants, including 23 inpatients, who were antipsychotic-free over the past 6 months first episode...
Background Depressive symptoms are often seen in schizophrenia. The overlap presentation makes it difficult to distinguish depressive from the negative of adipokine leptin was found be altered both depression and There few studies focusing on prediction diagnosis evaluation ObjectiveAims To assess plasma level patients with schizophrenia its relationships symptoms. Methods Cross-sectional were applied (1) compare levels between (n=74) healthy controls (n=50); (2) investigate relationship...
Schizophrenia is a chronic debilitating disease. The pathogenesis and treatment may be associated with inflammatory cytokines. There are few studies focusing on the prediction of cytokines in response to antipsychotics.To investigate whether would predict antipsychotics.Cross-sectional natural observational cohort were applied to:(1) compare baseline levels serum IL-1β, TNF-α MCP-1 between schizophrenia (n=64) healthy controls (n=53); (2) To impact psychopathology following olanzapine...
Background: The phospholipase A2 Group 6 ( PLA2G6 , also known as PLA2, PARK14 and iPLA2 ) gene encodes a group VIA calcium-independent A2. Genetic polymorphism of has been indicated to be involved in conferring susceptibility for Parkinson's disease (PD), whereas conclusive results have not obtained. Thus, we intended conduct systematic review determine if genetic variation confers greater PD. Methods: All case-control studies that investigated the association polymorphisms with risk PD...
TPN672 [7-(2-(4-(benzothiophen-4-yl) piperazin-1-yl)ethyl)quinolin-2(1H)-one maleate] is a novel antipsychotic candidate with high affinity for serotonin and dopamine receptors that currently in clinical trial the treatment of psychiatric disorders. In vitro binding study showed exhibited extremely 1A receptor (5-HT<sub>1A</sub>R) (<i>K</i><sub>i</sub> = 0.23 nM) 5-HT<sub>2A</sub>R 2.58 as well moderate D<sub>3</sub>R 11.55 D<sub>2</sub>R 17.91 nM). functional assays demonstrated acted...