A5036744911- Bone Tissue Engineering Materials
- Anatomy and Medical Technology
- Bone fractures and treatments
- Orthopaedic implants and arthroplasty
- 3D Printing in Biomedical Research
- Orthopedic Infections and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Dental Implant Techniques and Outcomes
- Digital Imaging in Medicine
- COVID-19 and healthcare impacts
- Infection Control and Ventilation
- Wound Healing and Treatments
- Innovations in Medical Education
- Additive Manufacturing and 3D Printing Technologies
- Retinal and Optic Conditions
- Reconstructive Surgery and Microvascular Techniques
- Tissue Engineering and Regenerative Medicine
- Orthopedic Surgery and Rehabilitation
- Surgical Simulation and Training
Goethe University Frankfurt
2020-2024
University Hospital Frankfurt
2024
Large bone defects are commonly treated by replacement with auto- and allografts, which have substantial drawbacks including limited supply, donor site morbidity, possible tissue rejection. This study aimed to improve defect treatment using a custom-made filament for engineering scaffolds. The consists of biodegradable polylactide acid (PLA) varying amount (up 20%) osteoconductive S53P4 bioglass. By employing an innovative, additive manufacturing technique, scaffolds optimized...
In Bone Tissue Engineering (BTE), autologous bone-regenerative cells are combined with a scaffold for large bone defect treatment (LBDT). Microporous, polylactic acid (PLA) scaffolds showed good healing results in small animals. However, transfer to animal models is not easily achieved simply by upscaling the design. Increasing diffusion distances have negative impact on cell survival and nutrition supply, leading death ultimately implant failure. Here, novel architecture was designed meet...
Critical-size bone defects up to 25 cm can be treated successfully using the induced membrane technique established by Masquelet. To shorten this procedure, human acellular dermis (HAD) has had success in replacing rat models. The aim of study was compare healing for smaller and larger an HAD a model. Using our femoral defect model rats, animals were placed into four groups 5 mm or 10 size set, either filling them with autologous spongiosa surrounding waiting form around cement spacer cavity...
Three-dimensional printing, especially fused filament fabrication (FFF), offers great possibilities in (bio-)medical applications, but a major downside is the difficulty sterilizing produced parts. This study evaluates questions of whether autoclaving possible solution for FFF-printed parts and if printer itself could be seen as an inherent sterilization method. In first step, investigation was performed on deformation cylindrically shaped test after running them through process....
Understanding the orientation of fracture lines and mechanisms is essential key to sufficient surgical therapy, but there still a lack visualization teaching methods in traumatology theory. 3D-printed models offer easy approach those fractures. This paper explains use possibility with 3-dimensional transitional fractures ankle.For generating 3D printable models, already obtained CT data were used segmented into its different tissues, especially parts concerning fracture. After segmentation...
Three-dimensional (3D) printing is considered a key technology in the production of customized scaffolds for bone tissue engineering. In previous work, we developed 3D printable, osteoconductive, hierarchical organized scaffold system. The material should be osteoinductive. Polylactic acid (PLA) (polymer)/Bioglass (BG) (mineral/ion source) composite materials are promising. Previous studies PLA/BG composites never exceed BG fractions 10%, as increase bioactive component negatively affects...
Abstract Objective This study aimed to evaluate the effectiveness of a 3D-printed hands-on radius fracture model for teaching courses. The was designed enhance understanding and knowledge fractures among medical students during their clinical training. Methods 3D models were generated using CT scans computer-aided design software. then printed Fused-Filament-Fabrication (FFF) technology. A total 170 undergraduate participated in divided into three groups. Each group assigned one learning...
Background The one-step membrane technique, using a human acellular dermal matrix (hADM), is an experimental method for treating large bone defects. This eliminates the need Masquelet induction step, shortening procedure while maintaining effectiveness. However, previous studies showed that colonizing hADM with marrow mononuclear cells (BMC) worsens healing, likely due to presence of CD8+ lymphocytes, which negatively affect regeneration. study aims investigate whether negative impact BMC on...