A5004702711- RNA Research and Splicing
- RNA modifications and cancer
- Hippo pathway signaling and YAP/TAZ
- Genomics and Chromatin Dynamics
- Genetics, Aging, and Longevity in Model Organisms
- RNA regulation and disease
- Reproductive Biology and Fertility
- Wnt/β-catenin signaling in development and cancer
- Microtubule and mitosis dynamics
Huashan Hospital
2023-2025
Fudan University
2022-2025
State Key Laboratory of Medical Neurobiology
2023-2024
The double-stranded RNA-binding protein Staufen1 (STAU1) regulates a variety of physiological and pathological events via mediating RNA metabolism. STAU1 overabundance was observed in tissues from mouse models fibroblasts patients with neurodegenerative diseases, accompanied by enhanced mTOR signaling impaired autophagic flux, while the underlying mechanism remains elusive. Here, we find that endogenous forms dynamic cytoplasmic condensate normal tumor cell lines, as well Huntington’s...
Sperms contribute essential parental factors, including the genome, centrosome, and oocyte-activation signals, to sexual reproduction. However, it remains unclear whether how sperms transfer RNA molecules regulate early embryonic development. Here, we show that Caenorhabditis elegans protein SPE-11 assembles into granules during meiotic divisions of spermatogenesis later mature a perinuclear structure where sperm RNAs localize. We reconstitute an liquid-phase scaffold in vitro find...