A5068391981- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Asymmetric Hydrogenation and Catalysis
- Organophosphorus compounds synthesis
- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Crystallography and molecular interactions
- Catalytic C–H Functionalization Methods
- Catalytic Cross-Coupling Reactions
- Chemical Synthesis and Analysis
- Chemical Synthesis and Reactions
- Coordination Chemistry and Organometallics
- Insect and Pesticide Research
- Oxidative Organic Chemistry Reactions
- Photopolymerization techniques and applications
- Organoboron and organosilicon chemistry
- Gut microbiota and health
- Bacterial Genetics and Biotechnology
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Neurobiology and Insect Physiology Research
- Epigenetics and DNA Methylation
- Viral Infectious Diseases and Gene Expression in Insects
- Advanced Synthetic Organic Chemistry
- Bacteriophages and microbial interactions
- Immune Cell Function and Interaction
BGI Group (China)
2025
BGI Research
2025
Nanjing Agricultural University
2023
National Institute of Advanced Industrial Science and Technology
2019-2021
University of Tsukuba
2019-2021
Liaocheng University
2016-2020
Division of Chemistry
2019
For over half a century, thousands of tons triphenylphosphine oxide Ph3P(O) have been produced every year from the chemical industries as useless waste. Here we disclose efficient transformations with cheap resource-abundant metallic sodium finely dispersed in paraffin oil. can be easily and selectively transformed to three reactive organophosphorus intermediates-sodium diphenylphosphinite, 5H-benzo[b]phosphindol-5-olate benzo[b]phosphindol-5-ide-that efficiently give corresponding...
Abstract The gut microbiota influences host immunity and metabolism, changes in its composition function have been implicated several non‐communicable diseases. Here, comparing germ‐free (GF) specific pathogen‐free (SPF) mice using spatial transcriptomics, single‐cell RNA sequencing, targeted bile acid metabolomics across multiple organs, we systematically assessed how the microbiota's absence affected organ morphology, immune homeostasis, acid, lipid metabolism. Through integrated analysis,...
The preparation, application, and reaction mechanism of sodium phosphide R2PNa other alkali metal phosphides R2PM (M = Li K) have been studied. could be prepared, accurately selectively, via the reactions SD (sodium finely dispersed in mineral oil) with phosphinites R2POR′ chlorophosphines R2PCl. also prepared from triarylphosphines diarylphosphines selective cleavage C–P bonds. Na was superior to K for these reactions. reacted a variety ArCl efficiently produce R2PAr. is ArBr ArI since they...
Functionalized P,C-stereogenic tertiary phosphine oxides were prepared by the addition of (RP)-menthyl phenylphosphine oxide to activated olefins, in high drP and drC, isolated excellent yields. The reaction was readily catalyzed Ca(OH)2 or occurred with gentle heating. A wide range substrates, including vinyl ketones, esters, nitriles, nitro alkenes, can be used reaction.
A diastereomeric mixture of secondary phosphine oxide is stereospecifically converted to chlorophosphine salt by treatment with oxalyl chloride, which stereoselectively affords P-inverted or retained tertiary phosphines, depending on the substitution aliphatic aromatic Grignard reagents, respectively, in high 99% yield and 99:1 dr. The repulsion π-electron aryl lone electron pair phosphorus proposed for P-retained substitution.
Water is unexpectedly found to determine a TfOH-catalyzed C–O cleavage reaction of trialkyl phosphites produce H-phosphonates or alkylphosphonates selectively.
The secondary RP-(-)-menthyl alkylphosphine oxide was confirmed as configurationally stable toward base and used in base-promoted alkylation, stereospecifically affording P-retained bis or functional tertiary phosphine oxides excellent yields. alkylated products were deoxygenated using oxalyl chloride followed by ZnCl2-NaBH4 to form P-inversed bidentate boranes high stereoselectivities.
Mythimna loreyi is an important agricultural pest with a sensitive sex pheromone communication system. To clarify the binding proteins (PBPs) and receptors (PRs) involved in perception for both understanding molecular olfactory mechanism developing new control strategy M. loreyi.
P,C-Stereogenic propargyl alcohols RC-3/SC-3' were prepared by the addition of (L)-menthyl-derived SPOs to propynals, which converted P,axial-stereogenic allenyl bisphosphine oxides. The chirality transfer was controlled α-carbon via syn [2,3]-sigmatropic rearrangement. For SC-3' linking weak WDG on alkynyl moiety, axis depended stereogenic phosphorus.
Various functional secondary and tertiary phosphines, or their derivatives, containing stationary chiral phosphorus flexible axis were prepared, which could be further modified to afford diversely chelating ligands. The axial chirality was fixed by stereogenic via a cyclic linkage of chemical bonds coordination with metallic ion.
A wide range of <italic>R</italic><sub>P</sub> or <italic>S</italic><sub>P</sub>-(<sc>l</sc>)-menthyl-containing SPOs were prepared <italic>via</italic> the reaction 1,1′-bi(2-naphthol) derived phosphonite with a metallic reagent excellent yield and dr.
Phosphine ligands with up to six chiral sites were prepared, starting from 2-phenylphenol, via O- and P-alkylation, cyclization, coupling. The chirality was transferred (L)-menthyl phosphorus, α-carbon, axis, achieve excellent diastereoselectivities. During an intramolecular SNAr reaction alkoxyl as the leaving groups, C-O bond converted a C-C bond. Both phosphine boranes oxides could be used for conversions, affording series of cyclic phosphines.
Abstract The additions of R P ‐ 1 or S to alkynyl esters stereo selectively afforded bis‐phosphinylated derivatives having up four C‐ and P‐chirogenic centers. stereochemistry was controlled by kinetic thermodynamic processes at lower higher temperature, respectively. At 100 °C, the bis‐adducts were obtained in 99% yield >99 : d.r.
Herein reported is the facial modification of tertiary phosphine boranes R3PBH3 by selective cleaving P-Ph bond sodium in which phosphide borohydride R2PNa(BH3) quantitatively generated and could be easily quenched electrophiles to furnish a series new high yields.
(2021). Conversion of α‐hydroxy(2,4,6‐trimethylbenzyl)diphenylphosphine oxide to TPO: oxidation vs decomposition. Phosphorus, Sulfur, and Silicon the Related Elements: Vol. 196, No. 3, pp. 207-210.
A Pd-catalyzed isomerization-coupling reaction of P-containing allyl chloride with amine afforded imine or enamine that was converted to various functionalized phosphorus derivatives via hydrolysis, reduction, Stork reactions. The confirmed proceed an isomerization a starting material and coupling the resulting vinyl amine.