An efficient oxygen–phosphoryl bond-forming reaction<italic>via</italic>iron-catalyzed cross dehydrogenative coupling has been developed. The reaction proceeds efficiently under oxidant- and halide-free conditions with H₂liberation, represents a straightforward method to prepare organophosphoryl compounds from alcohols P(O)–H compounds.

A direct decarbonylative Sonogashira coupling of terminal alkynes with carboxylic acids was achieved through palladium catalysis. This reaction did not use overstoichiometric oxidants, thus overcoming the homocoupling issue alkynes. Under conditions, a wide range including those bioactive ones could couple readily various alkynes, providing relative general method for preparing internal

A nickel-catalyzed decarbonylative thioetherification of carboxylic acids with thiols was developed. Under the reaction conditions, benzoic acids, cinnamic and benzyl coupled various including both aromatic aliphatic ones produce corresponding thioethers in up to 99% yields. Moreover, this applicable modification bioactive molecules such as 3-methylflavone-8-carboxylic acid, probenecid, flufenamic synthesis acaricide chlorbenside. These results well demonstrated potential synthetic value new...

Direct C–H arylation and acylation of azoles with carboxylic acids are achieved selectively through Pd/Cu cooperative catalysis: biaryls generated dppp as ligand, while biaryl ketones obtained high selectivity using dpph or Ph₂PCy ligand.

A CuH-catalyzed reductive coupling of nitroarenes with phosphine oxides is developed, which produces a series phosphamides in moderate to excellent yields good functional group tolerance. Gram-scale synthesis and late-stage modification nitro-aromatic molecule niclosamide are also successfully conducted. The mechanism study shows that the nitro transformed after being reduced nitroso nucleophilic addition procedure involved during reaction.

The trifluoromethylation of benzoic acids with TMSCF3 was achieved through nucleophilic substitution the use anhydrides as an in situ activating reagent. Under reaction conditions, a wide range carboxylic including bioactive ones worked well, thus providing facile and efficient method for preparing aryl trifluoromethyl ketones from readily available starting materials.

A Pd-catalyzed relatively general Michaelis–Arbuzov reaction of triaryl phosphites and aryl iodides for preparing useful phosphonates was developed. Interestingly, water can greatly facilitate the through a water-participating phosphonium intermediate rearrangement process, which also makes conditions rather mild. In comparison with known methods, this is milder more general, as it exhibits excellent functional group tolerance, be applied to various iodides, extended phosphonites...

An efficient method for the construction of C–P(V) and C–P(III) bonds via iron-catalyzed phosphorylation alcohols under ligand-free conditions is disclosed. This strategy represents a straightforward process to prepare series phosphine oxides compounds in good excellent yields from readily available P–H compounds. A plausible mechanism also proposed. We anticipate that this mode transforming simple would apply chemical synthesis widely.

The direct decarbonylative cyanation of benzoic acids with TMSCN was achieved through palladium catalysis. By this strategy, a wide range nitriles including those functional groups synthesized in good to high yields. Moreover, reaction applied modifying bioactive molecules such as adapalene, probenecid, telmisartan, and 3-methylflavone-8-carboxylic acid. These results demonstrate that new has potential synthetic value organic synthesis.

Reductive hydroamination of stable and readily available nitroarenes with unsaturated hydrocarbons represents practical access to amines. Herein, we report a simple Cu-catalyzed amine synthesis via the reductive inactive diarylacetylenes. A series diarylacetylenes are successfully transformed into secondary amines under mild conditions good functional group tolerance.

Water is unexpectedly found to determine a TfOH-catalyzed C–O cleavage reaction of trialkyl phosphites produce H-phosphonates or alkylphosphonates selectively.

The C-H amination and C-O alkenylation of aryl triflates was achieved through Pd/norbornene (NBE) cooperative catalysis. By this strategy, various ortho-alkenyl tertiary anilines including those bearing functional groups were produced in good to excellent yields. This reaction represents a new conversion model for phenoxides. It expands the scope Catellani-type reactions application phenoxides organic synthesis.

A "wet" process and two "dry" processes for converting phosphonate esters to phosphonic acids catalyzed by a Brønsted acid have been developed. Thus, in the presence of water, range alkyl-, alkenyl-, aryl-substituted phosphonates can be generally hydrolyzed corresponding good yields trifluoromethyl sulfonic (TfOH) at 140 °C (the wet process). On other hand, with specific substituents esters, conversion achieved under milder conditions absence water dry dibenzyl took place smoothly 80 toluene...

A base-promoted direct deaminative olefination of organoammonium salts was developed.

A palladium-catalyzed decarbonylative annulation of 2-arylbenzoic acids with internal alkynes via C(sp2)-H activation has been developed. series phenanthrenes were produced in moderate to good yield functional group tolerance. The mechanism study indicated that the should be rate-determining step during reaction.

Abstract The ortho C−H methylation and ipso C−O alkenylation of aryl triflates was regio‐selectively achieved in one pot by palladium/norbornene (NBE) synergistic catalysis. This work provides an efficient method for preparing poly‐substituted aromatics with (deuterated) methyl alkenyl groups from the readily available phenoxides.

A palladium-catalyzed difunctionalization of bicyclic alkenes with organoammonium salts and organoboronic compounds was reported. wide range functionalized cyclic products, including those bearing functional groups, were produced stereoselectively in good to excellent yields. The gram-scale experiment, one-pot operation, synthetic application β-borylated products further demonstrated the value this new reaction organic synthesis.

The direct cyclization of aryl triflates with terminal oxiranes was achieved through palladium/norbornene (Pd/NBE) cooperative catalysis. A wide range 2,3-dihydrobenzofurans were produced in good to high yields by the strategy. Good functional group tolerance also demonstrated. This reaction provides an alternative method for preparing value-added starting from readily available phenoxides and expands scope Catellani-type reactions organic synthesis.

The Pd-catalyzed Michaelis–Arbuzov rearrangement of triaryl phosphites to produce the corresponding arylphosphonates in good excellent yields is disclosed. In comparison traditional methods, this new method highly atom efficient and general, as it can be readily extended aryl phosphonites phosphinites. A gram-scale reaction (PhO)3P PhP(O)(OPh)2 with low loading catalyst was also demonstrated show its potentially practical usefulness. plausible mechanism proposed.

Abstract Using self-developed equipments, the solubility and rheology of Kelamayi live oils saturated by different alkane gases were investigated at pressures 0–2 MPa. The gas-oil ratio, Rs increases greatly with increasing saturation pressure while changes little temperature. pour point, abnormal viscosity/equilibrium viscosity, yield stress decrease significantly pressure, meaning that rheological properties improve gas dissolving. ability three to could be described as LPG>ethane>NG....

Comprehensive Summary A novel benzyl cation‐triggered site‐selective sp 2 C—H phosphorylation and etherification was developed. This reaction conducted under the transition metal‐free conditions through cation migration via dearomatization. Under conditions, derivatives of naphthalenes, benzofurans benzo[ b ]thiophenes all can be transformed into corresponding products in good to excellent yields. It provides a method construct C—P C—O bonds as well new strategy for benzylic...

Only mediated by KO t Bu, a deaminative carbon–carbon bond forming reaction of organoammonium salts with benzyl C(sp 3 )–H was developed.

A Pd-catalyzed decarbonylative Michaelis-Arbuzov reaction of carboxylic acids and triaryl phosphites for preparing aryl phosphonates under anhydride-free conditions has been reported. In this context, serve as both reagents activating the substrates reaction. There have no reports to date efficient direct methods