A5002676775- Endoplasmic Reticulum Stress and Disease
- Lipid metabolism and biosynthesis
- Microbial Metabolic Engineering and Bioproduction
- Fungal and yeast genetics research
- Proteoglycans and glycosaminoglycans research
- Bone health and osteoporosis research
- Cellular Mechanics and Interactions
- Metabolomics and Mass Spectrometry Studies
- Banking stability, regulation, efficiency
- Financial Markets and Investment Strategies
- Cancer Research and Treatments
- Parathyroid Disorders and Treatments
- Calcium Carbonate Crystallization and Inhibition
- Gut microbiota and health
- Immune cells in cancer
- Cancer Cells and Metastasis
- Digestive system and related health
- Bone health and treatments
- Glycosylation and Glycoproteins Research
- Adipose Tissue and Metabolism
- Probiotics and Fermented Foods
- Hematopoietic Stem Cell Transplantation
- Single-cell and spatial transcriptomics
- Sirtuins and Resveratrol in Medicine
- earthquake and tectonic studies
Columbia University
2021-2024
Nanyang Technological University
2017-2020
University of Illinois Urbana-Champaign
2016-2018
De La Salle University
2014
Cleveland State University
1998
The extracellular matrix (ECM) is critical in tumor growth and invasive potential of cancer cells. In glioblastoma tumors, some components the native brain ECM such as hyaluronic acid (HA) have been suggested key regulators processes associated with poor patient outlook invasion therapeutic resistance. Given importance cell-mediated remodeling during invasion, it likely that molecular weight available HA polymer may strongly influence GBM progression. Biomaterial platforms therefore provide...
Abstract Phospholipid homeostasis in biological membranes is essential to maintain functions of organelles such as the endoplasmic reticulum. perturbation has been associated cellular stress responses. However, most cases, implication membrane lipid changes homeostatic response not clearly defined. Previously, we reported that Saccharomyces cerevisiae adapts bilayer by upregulating several protein quality control pathways reticulum-associated degradation (ERAD) pathway and unfolded (UPR)....
Bone is constantly adapting each of its microstructural compartments by modeling and remodeling. These adaptations are delineated whether bone formation resorption coupled in space time. Time-lapse microCT imaging has become a valuable technique for characterizing dynamics 3D. Our previous study used longitudinal to quantify remodeling across the microstructure response PTH treatment mechanical loading. Here, we detail our voxel-tracking specifically identify time-dependent examining...
This study determined cytotoxicity of probiotic Lactobacillus spp. from Philippine dairy products on cancer cells and normal fibroblasts their effects expression early apoptotic-promoting cfos, cjun proinflammatory cytokine IL-1β, TNF-α genes. Cultures were Yakult, Bear Brand Probiotic Drink, Nido3+ Powdered Milk. Filter-sterilized supernatants cultures evaluated for to colon (HT-29 HCT116), leukemia (THP-1), human dermal (HDFn) using PrestoBlue. Bleomycin was the positive control. Absolute...
Crack events developed during uniaxial compression of cortical bones cut from femurs developing pigs several ages (4, 12, and 20 weeks) generate avalanches. These avalanches have been investigated by acoustic emission analysis techniques. The avalanche energies are power-law distributed over more than four decades. Such behavior indicates the absence characteristic scales suggests criticality. statistical distributions waiting times depend on pig age indicate that become stronger, but less...
Lipid droplets (LDs) are implicated in conditions of lipid and protein dysregulation. The fat storage-inducing transmembrane (FIT; also known as FITM) family induces LD formation. Here, we establish a model system to study the role Saccharomyces cerevisiae FIT homologues (ScFIT), SCS3 YFT2, proteostasis stress response pathways. While biogenesis basal endoplasmic reticulum (ER) stress-induced unfolded (UPR) remain unaltered ScFIT mutants, was found be essential for proper UPR activation...
The various functions of the skeleton are influenced by extracellular cues, hormones, and neurotransmitters. One type neuronal regulation favors bone mass accrual inhibiting sympathetic nervous system (SNS) activity. This observation raises questions about transcriptional mechanisms regulating catecholamine synthesis. Using a combination genetic pharmacological studies, we found that histone deacetylase sirtuin 1 (SIRT1) is modulator control mass. Neuronal SIRT1 reduced increasing SNS...
ABSTRACT Background Phospholipid homeostasis in biological membranes is essential to maintain functions of organelles such as the endoplasmic reticulum. perturbation has been associated non-alcoholic fatty liver disease, obesity and other metabolic disorders. However, most cases, significance lipid disequilibrium remains unclear. Previously, we reported that Saccharomyces cerevisiae adapts by upregulating several protein quality control pathways reticulum-associated degradation (ERAD)...
Hematopoietic stem and progenitor cells (HSPC) are regulated by interactions with stromal in the bone marrow (BM) cavity, which can be segregated into two spatially defined central (CM) endosteal (Endo) compartments. However, importance of this spatial compartmentalization for BM responses to inflammation neoplasia remains largely unknown. Here, we extensively validate a combination scRNA-seq profiling matching flow cytometry isolation that reproducibly identifies 7 key CM Endo populations...
Idiopathic osteoporosis (IOP) is a rare form of early-onset diagnosed in patients with no known metabolic or hormonal cause bone loss and unknown pathogenesis. Patients IOP commonly report both childhood fractures family history osteoporosis, raising the possibility genetic etiologies IOP. Whole-exome sequencing analyses different cohorts identified multiple variants melatonin receptor 1A ( MTNR1A ) potential pathogenic outcome. A variant (rs374152717) was found members an Ashkenazi Jewish...
Abstract The extracellular matrix (ECM) is critical in tumor growth and invasive potential of cancer cells. In glioblastoma tumors, some components the native brain ECM such as hyaluronic acid (HA) have been suggested key regulators processes associated with poor patient outlook invasion therapeutic resistance. Given importance cell-mediated remodeling during invasion, it likely that molecular weight available HA polymer may strongly influence GBM progression. Biomaterial platforms therefore...
Reviews previous research on the announcement effects of changes in US Federal Reserve policies and presents a study impact federal funds rate discount since current chairman took office (1988) treasury bills/bonds stock markets. Uses event methodology to show that there is no significant effect cumulative excess returns for any three markets, although bill market displayed greatest reaction; reactions were similar either type change.
Lipid droplets (LDs) have long been regarded as inert cytoplasmic organelles with the primary function of housing excess intracellular lipids. More recently, LDs strongly implicated in conditions lipid and protein dysregulation. The fat storage inducing transmembrane (FIT) family proteins comprises evolutionarily conserved endoplasmic reticulum (ER)-resident that reported to induce LD formation. Here, we establish a model system study role S. cerevisiae FIT homologues ( ScFIT ), SCS3 YFT2 ,...