A5004010329- Respiratory viral infections research
- Congenital Diaphragmatic Hernia Studies
- Neonatal Respiratory Health Research
- Pneumonia and Respiratory Infections
- Viral gastroenteritis research and epidemiology
- Emergency and Acute Care Studies
- Tracheal and airway disorders
- Animal Virus Infections Studies
- Travel-related health issues
- SARS-CoV-2 detection and testing
- Energy Harvesting in Wireless Networks
- Cardiovascular Conditions and Treatments
- Adolescent Sexual and Reproductive Health
- Pediatric health and respiratory diseases
- Pleural and Pulmonary Diseases
- Mechanical Circulatory Support Devices
- MicroRNA in disease regulation
- Kawasaki Disease and Coronary Complications
- Tourism, Volunteerism, and Development
Akershus University Hospital
2011-2024
University of Oslo
2011-2013
Respiratory syncytial virus (RSV) infection is a common cause of pediatric hospitalization. microRNA, key regulators the immune system, have not previously been investigated in respiratory specimens during viral infection. We microRNA expression nasal mucosa 42 RSV-positive infants, also comparing between disease severity subgroups. Nasal cytology were collected from infants and healthy controls. 32 selected by microarray for qPCR verification 19 control, 16 mild, 7 moderate severe samples....
To evaluate risk factors for severe disease in children under 59 months of age hospitalized with respiratory syncytial virus (RSV) infection.We prospectively enrolled 1,096 cases laboratory confirmed RSV infection during three consecutive seasons 2015-2018. Potential were retrieved through patient questionnaires and linkage to national health registries. Need support (invasive ventilation, bi-level positive airway pressure, or continuous pressure), length stay exceeding 72 h used as measures...
Objective There is conflicting evidence whether subtypes of Respiratory syncytial virus have different seasonality or are differentially associated with clinical severity. We aimed to explore the associations between disease severity and RSV RSV-A RSV-B describe circulation pattern by season age. Methods Active prospective hospital surveillance for in children <59 months age was conducted during 2015–2018. All febrile 12–59 were enrolled, whereas <12 eligible if presenting fever...
Fast- and high-throughput molecular workflows require sample matrices to be suitable for automation. Respiratory swabs are better suited this purpose compared the more viscous nasopharyngeal aspirates. Samples collected by aspiration flocked swab from 81 children were detection recovery of respiratory viruses. Using real-time RT-PCR, no statistically significant differences in virus between two types found, supporting use aged one month years.
The association between gene expression at birth of 11 candidate genes with important innate and adaptive immune functions later respiratory syncytial virus (RSV) disease was investigated. Cord blood collected from 2108 newborns. Forty-seven were subsequently RSV positive. Gene analysis by quantitative reverse transcription–polymerase chain reaction compared to 17 controls. There downregulation interleukin 7 receptor (IL7R) (P = .0001) chemokine (CCR7) .002), in the severe subcategory,...
Respiratory syncytial virus (RSV) is one of the most important causes pediatric hospital admissions in developed world. The ribonuclease Dicer an regulator gene expression and cellular function via RNA interference, may also have anti-viral functions. A previous microarray analysis cord blood 5 patients with RSV disease suggested downregulation Dicer. In order to further investigate whether reduced can predispose newborns disease, we analyzed 37 infants confirmed disease. 2108 was collected....
To estimate age-specific incidence of medically attended respiratory syncytial virus (RSV) infections in hospitalised Norwegian children and describe disease epidemiology.Active prospective hospital surveillance for RSV <59 months age was conducted during 2015-2018. All febrile 12-59 were enrolled, whereas <12 enrolled based on symptoms regardless fever. Surveillance data linked to national registry the clinical burden RSV.Of 1096 (40%) infected with RSV. The highest rates found 1 month age,...
Respiratory syncytial virus (RSV) infection is an important cause of hospitalization in previously healthy infants. Immunological mechanisms predisposing infants to severe disease are poorly understood. Early biomarkers for severity may assist clinical decisions. We investigated T-cell receptor excision circles (TREC), episomal DNA made during thymic rearrangement, and a marker thymus activity, both neonatal screening cards as risk factor RSV severity.One hundred thirteen patients...
Sir,In the present journal, a study of paediatric community-acquired pneumonia (CAP) complicated by parapneumonic effusion showed broad aetiological spectrum,[1] thus contradicting widely held ...
Viral lower respiratory tract infection (VLRTI) is the most common cause of hospital admission among small children in high-income countries. Guidelines to identify need are lacking literature. In December 2012, our introduced strict guidelines for admission. This study aims retrospectively evaluate safety and efficacy guidelines. We performed a single-center retrospective administrative database search medical record review. ICD-10 codes identified < 24 months assessed at emergency...