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Meena V. Patel

ORCID: 0000-0003-2068-6954
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About
Contact & Profiles
A5031435909
Research Areas
  • Monoclonal and Polyclonal Antibodies Research
  • Cytokine Signaling Pathways and Interactions
  • Ion channel regulation and function
  • Asthma and respiratory diseases
  • HER2/EGFR in Cancer Research
  • Neuroscience and Neuropharmacology Research
  • Pain Mechanisms and Treatments

AbbVie (United States)
 2022-2024

 Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate
OPENALEX - Publications 
Adrian D. Hobson Michael J. McPherson Martin E. Hayes Christian Goess Xiang Li and 29 more Zhou Jian Zhongyuan Wang Yajie Yu Jin‐Dong Yang Liang Sun Qiang Zhang Pei Qu Shi Yang Axel Hernandez Shaughn H. Bryant Suzanne Mathieu Agnieszka K. Bischoff Julia Fitzgibbons Ling C. Santora Lu Wang Lu Wang Margaret M. Fettis Xiaofeng Li Christopher C. Marvin Zhi Wang Meena V. Patel Diana L. Schmidt Tongmei Li John T. Randolph Rodger F. Henry Candace Graff Yu Tian Ana L. Aguirre Anurupa Shrestha

Using a convergent synthetic route to enable multiple points of diversity, series glucocorticoid receptor modulators (GRM) were profiled for potency, selectivity, and drug-like properties in vitro. Despite covering large range profiling the nonconjugated small molecule was suboptimal they conjugated mouse antitumor necrosis factor (TNF) antibody using MP-Ala-Ala linker. Screening resulting drug conjugates (ADCs) provided better assessment efficacy physical properties, reinforcing need...

10.1021/acs.jmedchem.2c01579 article EN Journal of Medicinal Chemistry 2022-11-17
 Anti-TNF Thioester Glucocorticoid Antibody–Drug Conjugate Fully Inhibits Inflammation with Minimal Effect on Systemic Corticosterone Levels in a Mouse Arthritis Model
OPENALEX - Publications 
Christopher C. Marvin Adrian D. Hobson Michael Mcpherson Martin E. Hayes Meena V. Patel and 13 more Diana L. Schmidt Tongmei Li John T. Randolph Agnieszka K. Bischoff Julia Fitzgibbons Lu Wang Lu Wang Axel Hernandez Ying Jia Christian Goess Shaughn H. Bryant Suzanne Mathieu Jianwen Xu

We describe the discovery of a thioester-containing glucocorticoid receptor modulator (GRM) payload and corresponding antibody-drug conjugate (ADC). Payload

10.1021/acs.jmedchem.4c00598 article EN Journal of Medicinal Chemistry 2024-05-23
 Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Nav1.7/ Nav1.8 blockers for the treatment of pain
OPENALEX - Publications 
Meena V. Patel Hillary M. Peltier Mark A. Matulenko John R. Koenig Marc J. C. Scanio and 19 more Rebecca J. Gum Odile F. El-Kouhen Meagan M. Fricano Greta Lundgaard Torben R. Neelands Xufeng Zhang Cenchen Zhan Madhavi Pai Nayereh Ghoreishi‐Haack Thomas J. Hudzik Gary Gintant Ruth L. Martin Steve McGaraughty Jun Xu Daniel A.J. Bow J. Cory Kalvass Philip R. Kym David A. DeGoey Michael E. Kort

10.1016/j.bmc.2022.116743 article EN Bioorganic & Medicinal Chemistry 2022-04-12
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