A5082673422- Sepsis Diagnosis and Treatment
- Bacterial Identification and Susceptibility Testing
- Streptococcal Infections and Treatments
- Nosocomial Infections in ICU
- Clinical Reasoning and Diagnostic Skills
- Gastrointestinal disorders and treatments
- Cardiovascular Function and Risk Factors
- Pancreatitis Pathology and Treatment
- Liver Disease and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Abdominal vascular conditions and treatments
- Liver Diseases and Immunity
- Gallbladder and Bile Duct Disorders
- Potassium and Related Disorders
- Liver Disease Diagnosis and Treatment
- Intestinal Malrotation and Obstruction Disorders
University of British Columbia
2019-2025
Background: Administering antimicrobial agents before obtaining blood cultures could potentially decrease time to treatment and improve outcomes, but it is unclear how this strategy affects diagnostic sensitivity. Objective: To determine the sensitivity of obtained shortly after initiation therapy in patients with severe manifestations sepsis. Design: Patient-level, single-group, study. (ClinicalTrials.gov: NCT01867905) Setting: 7 emergency departments North America. Participants: Adults...
Abstract Background Gastric outlet obstruction (GOO) refers to the clinical syndrome of epigastric pain and postprandial vomiting due mechanical in distal stomach or proximal duodenum. Management is undertaken alleviate symptoms with aim maintaining nutritional status improving quality life. Endoscopic gastroduodenal stenting surgical gastroenterostomy (SGE) are two established methods management GOO. Enteral associated stent malfunction such as migration often requiring reintervention; SGE...
Abstract Background Sepsis is a leading cause of morbidity, mortality, and health care costs worldwide. Methods We conducted multicenter, prospective cohort study evaluating the yield blood cultures drawn before after empiric antimicrobial administration among adults presenting to emergency department with severe manifestations sepsis. Enrolled patients who had requisite were followed for 90 days. explored independent association between culture positivity its time in relation 90-day...
Abstract Background Acute pancreatitis (AP) is an inflammatory condition associated with local and systemic complications. Severe can include the development of peripancreatic fluid collections necrotizing (NP). Vascular complications are one causes morbidity mortality in patients AP. Splanchnic thrombosis has been well described AP seen up to 24% patients. Extra splanchnic vessel thrombosis, including pulmonary embolism (PE), rare. Aims Describe a case acute NP collection complicated...
Abstract Background Of all microbiological tests performed, blood cultures have the most impact on patient care. Timely results are essential, especially in management of sepsis. While there multiple available culture systems market, they never been compared a prospective study critically ill population. Methods We performed an analysis FABLED cohort to compare and time positivity (TTP) 2 widely used systems: BacT/Alert BACTEC. In this multisite study, patients with severe manifestations...
Colonoscopy is widely used for the diagnosis and management of colorectal disease requires adequate bowel preparation. Ischemic colitis a form intestinal ischemia that presents with abdominal pain, diarrhea, hematochezia. Risk factors include advanced age, cardiovascular disease, diabetes. Both colonoscopy bisacodyl preparation have been described as rare causes ischemic less than 35 cases collectively in literature. Our review found these cases, there exists significant heterogeneity within...
Bloodstream infections in septic patients may be missed due to preceding antibiotic therapy prior obtaining blood cultures. We leveraged the FABLED cohort study determine if quick Sequential Organ Failure Assessment (qSOFA) score could reliably identify at higher risk of bacteremia who have false negative cultures previously administered therapy.We conducted a multi-centre diagnostic among adult with severe manifestations sepsis. Patients were enrolled one seven participating centres between...
Primary sclerosing cholangitis (PSC), with or without inflammatory bowel disease (IBD), confers the risk of cholangiocarcinoma. Isolated IBD may be an independent factor for We sought to compare cholangiocarcinoma phenotype and outcomes between patients PSC, IBD, neither.Patients malignancy were separated into cohorts by presence PSC IBD. Data regarding demographics, clinical presentation, therapeutic regimens, survival collected. Statistical analysis was carried out using GraphPad...
Abstract Background Current guidelines recommend obtaining blood cultures prior to antimicrobial therapy in patients with sepsis. Administering antimicrobials immediately without waiting for could potentially decrease time treatment and improve outcomes, but it is unclear the degree which this strategy impacts diagnostic yield. Methods We performed a patient-level, single-arm, trial. Seven urban emergency departments affiliated academic medical centers across Canada United States...