A5102934830- Protease and Inhibitor Mechanisms
- Cancer Mechanisms and Therapy
- Phagocytosis and Immune Regulation
- Signaling Pathways in Disease
- interferon and immune responses
- Electrospun Nanofibers in Biomedical Applications
- Peptidase Inhibition and Analysis
- Platelet Disorders and Treatments
- Cytokine Signaling Pathways and Interactions
- Blood Coagulation and Thrombosis Mechanisms
- Bone Tissue Engineering Materials
Tabriz University of Medical Sciences
2017-2020
Induction of thrombosis in tumor vasculature represents an appealing strategy for combating cancer. Herein, we combined unique intrinsic coagulation properties staphylocoagulase with new acquired functional potentials introduced by genetic engineering, to generate a novel bi-functional fusion protein consisting truncated coagulase (tCoa) bearing RGD motif on its C-terminus cancer therapy. We demonstrated that free failed elicit any significant thrombotic activity. Conversely, delivery...
Induction of selective thrombosis and infarction in tumor-feeding vessels represents an attractive strategy to combat cancer. Here we took advantage the unique coagulation properties staphylocoagulase genetically engineered it generate a new fusion protein with novel anti-cancer properties. This bi-functional consists truncated coagulase (tCoa) NGR (GNGRAHA) motif that recognizes CD13 αvβ3 integrin receptors, targeting tumor endothelial cells. Herein, report tCoa coupled by its C-terminus...
Today, composite scaffolds fabricated by natural and synthetic polymers have attracted a lot of attention among researchers in the field tissue engineering, given their combined properties that can play very useful role repairing damaged tissues. In current study, aloe vera-derived gel-blended poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofibrous scaffold was electrospinning, then, PHBV gel characterized scanning electron microscope, protein adsorption, cell attachment, tensile...