A5008921936- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Endoplasmic Reticulum Stress and Disease
- RNA modifications and cancer
- Helicobacter pylori-related gastroenterology studies
- Ferroptosis and cancer prognosis
- Gut microbiota and health
- Lipid metabolism and biosynthesis
- Metabolomics and Mass Spectrometry Studies
- Peroxisome Proliferator-Activated Receptors
- Child Nutrition and Feeding Issues
- Advanced Glycation End Products research
- Circular RNAs in diseases
- Neonatal and fetal brain pathology
- MicroRNA in disease regulation
- Diet, Metabolism, and Disease
- interferon and immune responses
- Liver physiology and pathology
- Drug-Induced Hepatotoxicity and Protection
- COVID-19 Clinical Research Studies
- Cancer Immunotherapy and Biomarkers
- Cancer Mechanisms and Therapy
- Curcumin's Biomedical Applications
- Autism Spectrum Disorder Research
- Macrophage Migration Inhibitory Factor
Fifth Affiliated Hospital of Zhengzhou University
2016-2025
Zhengzhou University
2014-2023
Cardinal Glennon Children’s Medical Center
2016-2018
Saint Louis University
2009-2018
Beijing Luhe Hospital Affiliated to Capital Medical University
2018
Second Affiliated Hospital of Zhengzhou University
2015
UCLouvain Saint-Louis Brussels
2014
Third Affiliated Hospital of Zhengzhou University
2009-2010
Boston Children's Hospital
2006
Abstract Autism spectrum disorder (ASD) is a neurodevelopmental that characterized by impairments in social interactions and communication, restricted interests repetitive behaviors. Several studies report high prevalence of gastrointestinal (GI) symptoms autistic individuals. Cumulative evidence reveals the gut microbiota its metabolites (especially short-chain fatty acids, SCFAs) play an important role GI disorders pathogenesis ASD. However, composition association with fecal SCFAs...
Diabetes is characterized by hyperglycaemia, which facilitates the formation of advanced glycation end-products (AGEs). Type 2 diabetes mellitus commonly accompanied non-alcoholic steatohepatitis, could lead to hepatic fibrosis. Receptor for AGEs (RAGE) mediates effects and associated with increased oxidative stress, cell growth inflammation. The phytochemical curcumin inhibits activation stellate cells (HSCs), major effectors during fibrogenesis. aim this study was explore underlying...
Activation of hepatic stellate cells (HSCs) is crucial to the development fibrosis in nonalcoholic fatty liver disease. Quiescent HSCs contain lipid droplets (LDs), whose depletion upon activation induces a fibrogenic gene program. Here we show that acid-binding protein (L-Fabp), an abundant cytosolic modulates acid (FA) metabolism enterocytes and hepatocytes, also HSC FA utilization turn regulates L-Fabp expression decreased 10-fold following activation, concomitant with LDs. Primary...
Non-alcoholic fatty liver disease (NAFLD) has become a common in recent decades. No effective treatment is currently available. Probiotics and natural functional food may be promising therapeutic approaches to this disease. The present study aims investigate the efficiency of anthraquinone from Cassia obtusifolia L. (AC) together with cholesterol-lowering probiotics (P) improve high-fat diet (HFD)-induced NAFLD rat models elucidate underlying mechanism. Cholesterol-lowering were screened out...
Abstract Immune cell infiltration is an important indicator of whether tumor patients will benefit from immunotherapy. Gastric cancer one the most common tumors in world, and new indicators immunotherapy are urgently needed. The aim this study was to construct ceRNA networks gastric with different degrees immune infiltration. We analyzed expression profiles retrieved Cancer Genome Atlas (TCGA) database found differentially expressed lncRNAs, mRNAs, miRNAs. A regulatory network constructed...
Abstract The abundance and type of immune cells in the tumor microenvironment (TME) significantly influence immunotherapy progression. However, role TME gastric cancer (GC) is poorly understood. We studied correlations, proportion, infiltration stromal GC tumors. Data analyses showed a significant association levels specific with pathological characteristics clinical outcomes GC. Furthermore, based on difference cells, patients were divided into two categories, those “immunologically hot”...
Nonalcoholic steatohepatitis (NASH) is commonly found in patients with obesity and often accompanied abnormally elevated levels of plasma leptin, i.e. hyperleptinemia. A relatively high population NASH develops hepatic fibrosis, even cirrhosis. Hepatic stellate cells (HSCs) are the major effector during liver fibrogenesis could be activated by leptin. The antioxidant curcumin, a phytochemical from turmeric, has been shown to suppress HSC activation vitro vivo. This project evaluate effect...
Helicobacter pylori (H. pylori) infection has been associated with gastric carcinogenesis. However, the precise involvement of LRP8, low-density lipoprotein receptor-related protein 8, in H. pathogenesis and cancer (GC) remains poorly understood. To investigate potential role LRP8 Three-dimensional human-derived organoids (hGO) (hGCO) were synthesized from tissues obtained human donors. In this work, multi-omics combined vivo vitro studies conducted to pylori-induced GC. We found that...
Abstract Background: Aging and long-term exposure to fine particulate matter (PM2.5) are associated with a higher risk of non-alcoholic fatty liver disease (NAFLD), but evidence on their combined effect is limited. We thus evaluated the joint effects accelerated biological aging PM2.5 incident NAFLD in UK cohort. Methods: included 296,917 Biobank participants without at baseline. Annual mean concentration was using land use regression model. Biological age assessed Klemera-Doubal method...
Obesity and type II diabetes mellitus are often associated with hyperleptinemia commonly accompanied by nonalcoholic steatohepatitis, which could cause hepatic fibrosis. During fibrogenesis, the major effectors stellate cells (HSCs) become active, coupling depletion of cellular lipid droplets downexpression genes relevant to accumulation. Accumulating evidence supports proposal that recovering accumulation lipids would inhibit HSC activation. We recently reported leptin stimulated...
BACKGROUND AND PURPOSE Hyperleptinemia is commonly found in obese patients, associated with non‐alcoholic steatohepatitis and hepatic fibrosis. Hepatic stellate cells (HSCs) are the most relevant effectors during fibrogenesis. We recently reported that leptin stimulated HSC activation, which was eliminated by curcumin, a phytochemical from turmeric. This study designed to explore underlying mechanisms, focusing on their effects intracellular glucose HSCs. hypothesized activation elevating...
To investigate the underlying mechanism of lncRNA myocardial infarction-associated transcript (MIAT) in hypoxic-ischemic (HI)-induced neonatal cerebral palsy.Neonatal rat model HI injury was established to detect motor function. LncRNA MIAT, miR-211, glial cell line-derived neurotrophic factor (GDNF) and caspase-3 expressions were measured by qRT-PCR or western blot. The apoptosis Neuro2A cells detected flow cytometry. RNA immunoprecipitation (RIP) pull-down assays performed confirm...
Breast cancer is one of the most common cancers. Oridonin, a traditional Chinese medicine, believed to inhibit tumor growth, but its particular effects on breast remain unknown. In this study, we examined oridonin's 4T1, MCF-7, and MDAMB-231 cellular activity using CCK8. Scratch assays were used detect migration. Oridonin's cell cycle studied flow cytometry, expression related proteins p53, CDK2, p21 was detected Western blot assays. Metabolomics changes in small molecule metabolites...
Through the roles of vitamin B1 and B12 in neuroprotection improving cerebral palsy symptoms have been previously noticed, action mechanism is still unclear. This study aims to investigate protective effect on neuron injury clarify inhibiting neurons apoptosis, focus role lncRNA MALAT1 this process. In order vivo apoptosis vitro, we, respectively, introduced into rat apoptosis-induced N2A by Oxygen Glucose Deprivation/reoxygenation (OGD/R). Our results demonstrated that treatment improved...
Gastric cancer (GC) is a highly fatal and common malignancy of the digestive system. Recent therapeutic advancements have significantly improved clinical outcomes in GC, but due to unavailability suitable molecular targets, large number patients do not respond immune checkpoint inhibitors (ICI) therapy. To identify validate potential prognostic targets gastric cancer, we used "inferCNV" R package for analyzing single-cell sequencing data (GSE112302) GC normal epithelial cells. First, by...
Abstract The environmental pollutant bisphenol A (BPA), used in the manufacture of plastic packaging materials for various diets, is widely distributed environment and causes severe hepatotoxicity by inducing oxidative stress. Artemisia argyi essential oil (AAEO), a volatile component isolated from H.Lév . & Vaniot , has pharmacological effects, especially hepatoprotective actions. However, potential effect AAEO BPA induced not been characterized. First, we analyzed chemical composition...
The bile acid nor-ursodeoxycholic (norUDCA) has many biological actions, including antiapoptotic effects. Homozygous PIZZ α-1-antitrypsin (A1AT)-deficient humans are known to be at risk for liver disease, cirrhosis, and cancer as a result of the accumulation toxic, A1AT mutant Z protein within hepatocytes. This triggers cell death in hepatocytes with largest Z-protein burdens, followed by compensatory proliferation. Proteolysis pathways hepatocyte, autophagy, act reduce intracellular burden...
Alpha-1 Antitrypsin (α1AT) Deficiency is a genetic disease in which accumulation of α1AT mutant Z (α1ATZ) protein the ER hepatocytes causes chronic liver injury, fibrosis, and hepatocellular carcinoma. No effective medical therapy currently available for disease. We previously found that norUDCA improves deficiency associated by promoting autophagic degradation α1ATZ mouse model The current study unravels novel underlying cellular mechanism modulates autophagy. HTOZ cells, modified from HeLa...
Abstract Gastric cancer has the fifth highest incidence of disease and is third leading cause cancer‐associated mortality in world. The etiology gastric complex needs to be fully elucidated. Thus, it necessary explore potential pathogenic genes pathways that contribute cancer. Gene expression profiles GSE33335 GSE54129 datasets were downloaded from Expression Omnibus database. differentially expressed (DEGs) compared identified using R software. DEGs then subjected gene set enrichment...