A5086974849- Cellular Mechanics and Interactions
- Advanced Fluorescence Microscopy Techniques
- Force Microscopy Techniques and Applications
- Heat shock proteins research
- Electrolyte and hormonal disorders
- Retinal Diseases and Treatments
- RNA Research and Splicing
- Mitochondrial Function and Pathology
- Alzheimer's disease research and treatments
- Genomics and Chromatin Dynamics
- Retinal Development and Disorders
- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Bone health and treatments
- Anesthesia and Neurotoxicity Research
- Neonatal Respiratory Health Research
- Genetic Neurodegenerative Diseases
Technion – Israel Institute of Technology
1984-2022
RS-23581, a synthetic analog of human PTH-related protein-(1-34), and the amino-terminal 34 amino acids bovine PTH [bPTH-(1-34)] increase bone mineral density. We wished to determine how quickly ultrastructure osteogenic cells, i.e. osteoblasts lining cancellous second lumbar vertebra ovariectomized rats was altered in response initiation cessation treatment. Ovariectomized were injected daily with 80 micrograms/kg bPTH-(1-34), or vehicle for 19 days. Animals killed throughout treatment...
Rigidity-dependent force generation involves no mechanosensing and is enslaved to a rigidity-independent contractile displacement.
Abstract Protein aggregation is a hallmark of neurodegeneration. Here, we find that Huntington’s disease-related HTT-polyQ induces cellular proteotoxic stress response, while ALS-related mutant FUS (mutFUS) leads to deteriorated proteostasis. Further exploring chaperone function as potential modifiers pathological in these contexts, reveal divergent effects naturally-occurring isoforms on different aggregate types. We identify complex the full-length (FL) DNAJB14 and DNAJB12, substantially...
ABSTRACT. The purpose of the present study was to determine normal relationship urine and plasma osmolality in pre‐term full‐term infants. Twenty‐nine 35 babies were studied during first week life. Random simultaneous samples measured for osmolality. Statistical analysis defined This suggests an osmotic threshold 282 mOsm/kg 291 babies, respectively. These values are different from 285–290 adolescents adults. nomograms provided may serve as a useful aid bedside diagnosis dysfunctional...
Abstract Amyloid-β (Aβ), reported as a significant constituent of drusen, was implicated in the pathophysiology age-related macular degeneration (AMD), yet identity major pathogenic Aβ species retina has remained hitherto unclear. Here, we examined in-vivo retinal impact distinct supramolecular assemblies Aβ. Fibrillar (Aβ40, Aβ42) and oligomeric (Aβ42) preparations showed clear biophysical hallmarks amyloid assemblies. Measures structure function were studied longitudinally following...
Abstract Cells’ ability to apply contractile forces their environment and sense its mechanical properties (e.g. rigidity) are among most fundamental features. Yet, the interrelations between contractility mechanosensing, in particular whether force generation depends on not understood. We use theory extensive experiments study time evolution of cellular show that they generated by time-dependent actomyosin displacements independent environment’s rigidity. Consequently, non-mechanosensitive....
Abstract Protein aggregation is a hallmark of many neurodegenerative diseases 1,2 . In order to cope with misfolding and aggregation, cells have evolved an elaborate network molecular chaperones, composed different families 3 But while chaperoning mechanisms for are well established, functional regulatory diversification within chaperone still largely mystery 4,5 Here we decided explore diversity, through the lens pathological aggregation. We revealed that naturally-occurring isoforms DNAJ...