A5083064739- Malaria Research and Control
- Computational Drug Discovery Methods
- Mosquito-borne diseases and control
- Biochemical and Molecular Research
- Tuberculosis Research and Epidemiology
- Genomics and Phylogenetic Studies
- Microbial Natural Products and Biosynthesis
- Cancer therapeutics and mechanisms
Wellcome Sanger Institute
2024
University of Cambridge
2021
Birkbeck, University of London
2021
Institute of Structural and Molecular Biology
2021
Abstract Artemisinin partial resistance (ART-R) in Plasmodium falciparum is one of the most pressing threats to global malaria control. Over last two decades, ART-R has spread widely across Southeast Asia, compromising public health strategies and hindering elimination efforts. As 2024, now emerged East Africa, with potential dramatically increase human mortality region. Mitigating requires detailed genomic surveillance point mutations kelch13 gene, primary determinant artemisinin...
Abstract Motivation Monitoring the genomic evolution of Plasmodium falciparum—the most widespread and deadliest human-infecting malaria species—is critical for making decisions in response to changes drug resistance, diagnostic test failures, vaccine effectiveness. The MalariaGEN data resources are world’s largest whole genome sequencing databases parasites. size complexity such is a barrier many potential end users both public health academic research. A user-friendly method accessing...