A5032688567- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Enzyme Catalysis and Immobilization
- Chemical Synthesis and Analysis
- Cystic Fibrosis Research Advances
- Amino Acid Enzymes and Metabolism
- Lung Cancer Treatments and Mutations
- Rheumatoid Arthritis Research and Therapies
- Microbial Metabolites in Food Biotechnology
- Inflammasome and immune disorders
- Neonatal Respiratory Health Research
- Endoplasmic Reticulum Stress and Disease
- Head and Neck Cancer Studies
- Systemic Lupus Erythematosus Research
- Enzyme Structure and Function
- Microbial Metabolic Engineering and Bioproduction
- Enzyme Production and Characterization
- Nanomaterials for catalytic reactions
- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- Autoimmune and Inflammatory Disorders Research
- Analytical Chemistry and Chromatography
- Histone Deacetylase Inhibitors Research
- Polyamine Metabolism and Applications
- Chemical Reactions and Isotopes
The Alfred Hospital
2025
Chinese University of Hong Kong
2023-2024
NIHR Leeds Musculoskeletal Biomedical Research Unit
2010-2023
University of Leeds
2011-2023
New York Academy of Sciences
2023
John Wiley & Sons (Germany)
2023
Moss Landing Marine Laboratories
2023
Hudson Institute
2023
Cystic Fibrosis Trust
2019-2020
St James's University Hospital
2013-2019
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnzyme-catalyzed organic synthesis: practical routes to aza sugars and their analogs for use as glycoprocessing inhibitorsGary C. Look, Christopher H. Fotsch, Chi Huey WongCite this: Acc. Chem. Res. 1993, 26, 4, 182–190Publication Date (Print):April 1, 1993Publication History Published online1 May 2002Published inissue 1 April 1993https://doi.org/10.1021/ar00028a008Request reuse permissionsArticle Views647Altmetric-Citations262LEARN ABOUT THESE...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnzyme-catalyzed aldol condensation for asymmetric synthesis of azasugars: synthesis, evaluation, and modeling glycosidase inhibitorsTetsuya Kajimoto, Kevin K. C. Liu, Richard L. Pederson, Ziyang Zhong, Yoshitaka Ichikawa, John A. Porco Jr., Chi Huey WongCite this: J. Am. Chem. Soc. 1991, 113, 16, 6187–6196Publication Date (Print):July 1, 1991Publication History Published online1 May 2002Published inissue 1 July...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLactobacillus kefir alcohol dehydrogenase: a useful catalyst for synthesisCurt W. Bradshaw, Werner Hummel, and Chi Huey WongCite this: J. Org. Chem. 1992, 57, 5, 1532–1536Publication Date (Print):February 1, 1992Publication History Published online1 May 2002Published inissue 1 February 1992https://pubs.acs.org/doi/10.1021/jo00031a037https://doi.org/10.1021/jo00031a037research-articleACS PublicationsRequest reuse permissionsArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of dibenzyl glycosyl phosphites using N,N-diethylphosphoramidite as phosphitylating reagent: an effective route to phosphates, nucleotides, and glycosidesMui Mui Sim, Hirosato Kondo, Chi Huey WongCite this: J. Am. Chem. Soc. 1993, 115, 6, 2260–2267Publication Date (Print):March 1, 1993Publication History Published online1 May 2002Published inissue 1 March...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnzyme-catalyzed synthesis of N-acetyllactosamine with in situ regeneration uridine 5'-diphosphate glucose and galactoseChi Huey Wong, Sharon L. Haynie, George M. WhitesidesCite this: J. Org. Chem. 1982, 47, 27, 5416–5418Publication Date (Print):December 1, 1982Publication History Published online1 May 2002Published inissue 1 December 1982https://pubs.acs.org/doi/10.1021/jo00148a045https://doi.org/10.1021/jo00148a045research-articleACS...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUse of a recombinant bacterial fructose-1,6-diphosphate aldolase in aldol reactions: preparative syntheses 1-deoxynojirimycin, 1-deoxymannojirimycin, 1,4-dideoxy-1,4-imino-D-arabinitol, and fagomineClaus H. Von der Osten, Anthony J. Sinskey, Carlos F. Barbas III, Richard L. Pederson, Yi Fong Wang, Chi Huey WongCite this: Am. Chem. Soc. 1989, 111, 11, 3924–3927Publication Date (Print):May 1, 1989Publication History Published online1 May...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnzymes in carbohydrate synthesis: N-acetylneuraminic acid aldolase catalyzed reactions and preparation of N-acetyl-2-deoxy-D-neuraminic derivativesMahn Joo. Kim, William J. Hennen, H. Marcel. Sweers, Chi Huey. WongCite this: Am. Chem. Soc. 1988, 110, 19, 6481–6486Publication Date (Print):September 1, 1988Publication History Published online1 May 2002Published inissue 1 September...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUse of dihydroxyacetone phosphate-dependent aldolases in the synthesis deoxy aza sugarsKevin K. C. Liu, Tetsuya Kajimoto, Lihren Chen, Ziyang Zhong, Yoshitaka Ichikawa, and Chi Huey WongCite this: J. Org. Chem. 1991, 56, 22, 6280–6289Publication Date (Print):October 1, 1991Publication History Published online1 May 2002Published inissue 1 October 1991https://pubs.acs.org/doi/10.1021/jo00022a013https://doi.org/10.1021/jo00022a013research-articleACS...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnzymes in carbohydrate synthesis. Lipase-catalyzed selective acylation and deacylation of furanose pyranose derivativesWilliam J. Hennen, H. Marcel Sweers, Yi Fong Wang, Chi Huey WongCite this: Org. Chem. 1988, 53, 21, 4939–4945Publication Date (Print):October 1, 1988Publication History Published online1 May 2002Published inissue 1 October 1988https://doi.org/10.1021/jo00256a008RIGHTS & PERMISSIONSArticle Views1698Altmetric-Citations168LEARN ABOUT...
<h3>Background</h3> The NLRP3-inflammasome, implicated in the pathogenesis of several inflammatory disorders, has been analysed rheumatoid arthritis (RA). <h3>Methods</h3> Relative gene expression NLRP3-inflammasome components was characterised PBMCs 29 patients receiving infliximab. A total 1278 Caucasian with RA from Biologics Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS) cohort tumour necrosis factor (TNF) antagonists (infliximab, adalimumab etanercept) were...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT.beta.-Sialyl phosphite and phosphoramidite: synthesis application to the chemoenzymic of CMP-sialic acid sialyl oligosaccharidesHirosato Kondo, Yoshitaka Ichikawa, Chi Huey WongCite this: J. Am. Chem. Soc. 1992, 114, 22, 8748–8750Publication Date (Print):October 1, 1992Publication History Published online1 May 2002Published inissue 1 October 1992https://pubs.acs.org/doi/10.1021/ja00048a085https://doi.org/10.1021/ja00048a085research-articleACS...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnzymes in organic synthesis: use of subtilisin and a highly stable mutant derived from multiple site-specific mutationsChi Huey Wong, S. T. Chen, William J. Hennen, Jeffrey A. Bibbs, Y. F. Wang, Jennifer L. C. Liu, Michael W. Pantoliano, Marc Whitlow, Philip N. BryanCite this: Am. Chem. Soc. 1990, 112, 3, 945–953Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnzyme-catalyzed regioselective deacylation of protected sugars in carbohydrate synthesisHenri M. Sweers and Chi Huey. WongCite this: J. Am. Chem. Soc. 1986, 108, 20, 6421–6422Publication Date (Print):October 1, 1986Publication History Published online1 May 2002Published inissue 1 October 1986https://pubs.acs.org/doi/10.1021/ja00280a068https://doi.org/10.1021/ja00280a068research-articleACS PublicationsRequest reuse permissionsArticle...
To characterize the role of histone deacetylase (HDAC) activity in rheumatoid arthritis (RA) and to evaluate effects MI192, a novel HDAC-3-selective inhibitor, compared with established nonselective HDAC inhibitor trichostatin A (TSA), on proinflammatory cytokine production.Activity acetyltransferase was measured peripheral blood mononuclear cells (PBMCs) from RA patients by spectrophotometric assay, prior after 12 weeks etanercept therapy. The treatment production both healthy PBMCs were...
Previously, we showed that serum and monocytes from patients with CF exhibit an enhanced NLRP3-inflammasome signature increased IL-18, IL-1β, caspase-1 activity ASC speck release (Scambler et al. eLife 2019). Here show CFTR modulators down regulate this exaggerated proinflammatory response following LPS/ATP stimulation. In vitro application of ivacaftor/lumacaftor or ivacaftor/tezacaftor to a significant reduction in whereas IL-1β was only reduced ivacaftor/tezacaftor. Thirteen adults...
Cystic Fibrosis (CF) is a monogenic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, resulting defective CFTR-mediated chloride and bicarbonate transport, with dysregulation of epithelial sodium channels (ENaC). These changes alter fluid electrolyte homeostasis result an exaggerated proinflammatory response driven, part, infection. We tested hypothesis that NLRP3 inflammasome activation ENaC upregulation drives innate-immune responses this...
The mammalian oviduct provides an optimal environment for the maturation of gametes, fertilization, and early embryonic development. Secretory cells lining lumen synthesize secrete proteins that have been shown to interact with influence activities gametes embryos. We hypothesized presence in alters oviductal secretory proteomic profile. used a combination two-dimensional gel electrophoresis liquid chromatography-tandem mass spectrometry identify protein secretions were altered response...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLipase-catalyzed irreversible transesterification for preparative synthesis of chiral glycerol derivativesYi Fong Wang and Chi Huey WongCite this: J. Org. Chem. 1988, 53, 13, 3127–3129Publication Date (Print):June 1, 1988Publication History Published online1 May 2002Published inissue 1 June 1988https://pubs.acs.org/doi/10.1021/jo00248a046https://doi.org/10.1021/jo00248a046research-articleACS PublicationsRequest reuse permissionsArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Pseudomonas sp. alcohol dehydrogenase with broad substrate specificity and unusual stereospecificity for organic synthesisCurt W. Bradshaw, Hong Fu, Gwo Jenn Shen, Chi Huey WongCite this: J. Org. Chem. 1992, 57, 5, 1526–1532Publication Date (Print):February 1, 1992Publication History Published online1 May 2002Published inissue 1 February 1992https://pubs.acs.org/doi/10.1021/jo00031a036https://doi.org/10.1021/jo00031a036research-articleACS...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDeoxyribose-5-phosphate aldolase as a synthetic catalystCarlos F. Barbas III, Yi Fong Wang, and Chi Huey WongCite this: J. Am. Chem. Soc. 1990, 112, 5, 2013–2014Publication Date (Print):February 1, 1990Publication History Published online1 May 2002Published inissue 1 February 1990https://pubs.acs.org/doi/10.1021/ja00161a064https://doi.org/10.1021/ja00161a064research-articleACS PublicationsRequest reuse permissionsArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of sugars by aldolase-catalyzed condensation reactionsChi Huey Wong and George M. WhitesidesCite this: J. Org. Chem. 1983, 48, 19, 3199–3205Publication Date (Print):September 1, 1983Publication History Published online1 May 2002Published inissue 1 September 1983https://doi.org/10.1021/jo00167a012Request reuse permissionsArticle Views867Altmetric-Citations115LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChloroperoxidase-catalyzed asymmetric synthesis: enantioselective reactions of chiral hydroperoxides with sulfides and bromohydroxylation glycalsHong Fu, Hirosato Kondo, Yoshitaka Ichikawa, Gary C. Look, Chi Huey WongCite this: J. Org. Chem. 1992, 57, 26, 7265–7270Publication Date (Print):December 1, 1992Publication History Published online1 May 2002Published inissue 1 December...
Oleamide (1, cis-9-octadecenamide) is a naturally occurring brain constituent that has been shown to accumulate and disappear under conditions of sleep deprivation recovery, respectively. Synthetic 1 found induce in structurally specific manner at nanomolar quantities. Hydrolysis by an enzyme (oleamide hydrolase) present the cell membrane rapidly degrades oleamide oleic acid (cis-9-octadecenoic acid). Such observations suggest may constitute prototypical member class fatty primary amide...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA highly efficient multienzyme system for the one-step synthesis of a sialyl trisaccharide: in situ generation sialic acid and N-acetyllactosamine coupled with regeneration UDP-glucose, UDP-galactose CMP-sialic acidYoshitaka Ichikawa, Jennifer Lin Chun Liu, Gwo Jenn Shen, Chi Huey WongCite this: J. Am. Chem. Soc. 1991, 113, 16, 6300–6302Publication Date (Print):July 1, 1991Publication History Published online1 May 2002Published inissue 1 July...