A5007396466- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Mast cells and histamine
- Eosinophilic Esophagitis
- Streptococcal Infections and Treatments
- HER2/EGFR in Cancer Research
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Monoclonal and Polyclonal Antibodies Research
- Food Allergy and Anaphylaxis Research
- Complementary and Alternative Medicine Studies
- Cancer-related Molecular Pathways
- Viral Infections and Immunology Research
- Radiation Dose and Imaging
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Inflammasome and immune disorders
- Immune Cell Function and Interaction
- Erythrocyte Function and Pathophysiology
- Cancer, Stress, Anesthesia, and Immune Response
- Urticaria and Related Conditions
- Menstrual Health and Disorders
- Cytomegalovirus and herpesvirus research
- Radiopharmaceutical Chemistry and Applications
- Advanced Breast Cancer Therapies
Guru Teg Bahadur Hospital
2024
University College of Medical Sciences
2024
Regeneron (United States)
2019-2023
Florida Atlantic University
2020
Seattle University
2018
Medical University of South Carolina
2014
National Institute for Occupational Safety and Health
2014
Centers for Disease Control and Prevention
2014
BackgroundSevere inflammatory airway diseases are associated with inflammation that does not resolve, leading to structural changes and an overall environment primed for exacerbations.ObjectiveWe sought identify inhibit pathways perpetuate this heightened state because could lead therapies allow a more quiescent lung is less predisposed symptoms exacerbations.MethodsUsing prolonged exposure house dust mite in mice, we developed mouse model of persistent exacerbating disease characterized by...
Immunoglobulin E (IgE) plays an important role in allergic diseases. Nevertheless, the source of IgE serological memory remains controversial. We reexamined mechanism allergy using a dual reporter system to track IgE+ plasma cells mice. Short-term allergen exposure resulted generation that resided mainly secondary lymphoid organs and produced was unable degranulate mast cells. In contrast, chronic led long-lived were primarily derived from sequential class switching IgG1, accumulated bone...
Immunoglobulin E (IgE) is a key driver of type 1 hypersensitivity reactions and allergic disorders, which are globally increasing in number severity. Although eliminating pathogenic IgE may be powerful way to treat allergy, no therapeutic strategy reported date can fully ablate production. Interleukin-4 receptor α (IL-4Rα) signaling required for class switching, IL-4Rα blockade gradually reduces, but does not eliminate, IgE. The persistence after due long-lived + plasma cells that maintain...
Human cytomegalovirus (HCMV) is a risk factor for many human diseases, but among exposed individuals, not everyone equally likely to develop HCMV-spurred implying the presence of host genetic factors that might modulate immunity this virus. Here, we show antibody responsiveness HCMV glycoprotein B (gB) significantly associated with particular immunoglobulin GM (γ marker) genotypes. Anti-HCMV gB levels were highest in 17/17 homozygotes, intermediate 3/17 heterozygotes, and lowest 3/3...
Immunoglobulin γ marker (GM) and κ (KM) allotypes, hereditary antigenic determinants of chains, respectively, have been shown to be associated with immunity a variety self nonself antigens, but their possible contribution the tumor-associated antigens epidermal growth factor receptor (EGFR) EGFR variant (v)III has not evaluated. The aim present investigation was determine whether interindividual variation in endogenous antibody responsiveness EGFRvIII is particular GM, KM, Fcγ (FcγR)...
INTRODUCTION: Cyclic Vomiting Syndrome (CVS) is a functional gastrointestinal phenomenon thought to primarily affect children and adolescents. CVS characterized by recurrent episodes of nausea vomiting interspersed with symptom-free periods. Episodes are triggered psychological, situational or physical stressors (infections, lack sleep, menstrual periods). We present rare case catamenial in young adult. CASE DESCRIPTION/METHODS: A 22-year-old G0P0 female no past history presented report...
Immunoglobulin E (IgE) plays an important role in allergic diseases. Nevertheless, the cellular and clonal origins of allergen-specific IgE, IgG1 IgA secreting plasma cells (PCs) following allergen exposure are poorly understood. Here, we investigated their evolution contribution to humoral immunity after house dust mite (HDM) using IgEVenus Blimp-1mCherry reporter mice. We show that short-term (< 4 weeks) results generation IgE+ PCs mainly reside lung dLNs, while long-term (>10 leads...
Fibroadenomas are one among the foremost common benign tumors of breast within adolescent population. They account for 68% all plenty and 44%–94% biopsied lesions. can vary from well masses to painful speedily growing which will cause vital esthetic distortions breast. Given prevalence fibroadenomas in population also psychosocial morbidity finding a mass breast, it's imperative physicians treating patients be acquainted up this point with sickness process. The goal text is produce brief...